Joanna Frąckiewicz

Hematological parameters and all-cause mortality: a prospective study of older people

BackgroundThe effect of low and high concentration of some hematological parameters in the blood can have a negative impact on health.AimTherefore, we investigated the associations between hematological parameters and all-cause mortality among older people living in Poland.MethodsThe study was carried out among 75–80-year-old participants (n = 403) from Warsaw and Olsztyn regions, Poland. Information on lifestyle factors and food consumption were obtained at baseline (June 1, 1999) using a self-administered questionnaire. Red blood cell, haemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), and mean corpuscular haemoglobin concentration (MCHC) were determined. The data on deaths from all-causes were collected from the baseline until October 31, 2006. During an average of 7.4 years of follow-up, we ascertained 154 cases of death from all-causes.ResultsCompared with men in the lowest tertile of MCV, MCH, and MCHC, the multivariable hazard ratios (HRs) of all-cause mortality in those in the highest tertile were 0.35 (95% CI, 0.17–0.73), 0.32 (95% CI, 0.16–0.67), and 0.44 (95% CI, 0.22–0.88), respectively. In contrast, among women after combining the second and the third tertiles of MCV, MCH, and MCHC, the HRs were 2.01 (95% CI, 1.01–3.99), 1.71 (95% CI, 0.85–3.43), and 1.09 (95% CI, 0.62–1.94), respectively.Discussion/conclusionWe observed inverse associations between some hematological parameters and all-cause mortality among men, but not among women. This may be explained by a difference in iron metabolism, iron status, hormone regulations, or the occurrence of some diseases.

Somatotype, diet and nutritional status of women

Abstract The relationship between energy value and nutrients intake and the body shape and size parameters (weight, height, waist and hip circumferences) has become an interesting research area for nutritionists and dieticians. The aim of this study was to determine the relationship between the body shape and size parameters (weight, height, waist and hip circumferences), somatotype (according to the Rohrer (RI) index) and energy value and nutrients intake of women. The study was conducted in 2014 and 2016 on 148 female volunteers aged 57-88 from the Mazovian and Lublin province (Poland). Sample selection was targeted at elderly people with different body types. The exclusion criteria were: multi-organ failure, cancer and disability. Then among the subjects, a survey was conducted, that included demographic data, lifestyle, health status and vitamins and minerals supplements use. Food intake has been assessed using a 3-day dietary food records. The somatotype was determined using the RI with the Curtis key, classifying the subjects as ectomorphic (n=30), mesomorphic (n=31) and endomorphic (n=87). The somatotype was significantly related to place of residence, physical activity, waist and hip circumference, WHR and BMI index, total protein intake, animal protein intake, vitamin E intake (p≤0.05) and to fat, phosphorus and thiamine intake (p≤0.1). The obtained results showed that the place of residence, physical activity, chronic diseases, the use of specialized diet, body weight fluctuations, BMI and WHR were different depending on the somatotype in the examined group of women. Endomorphic subjects had significantly greater waist and hip circumference and diastolic blood pressure compared to the other somatotypes. The somatotype had only a significant effect on total protein, animal protein and vitamin E intake, and ectomorphic elderly women may be particularly susceptible to nutrient deficiencies. Due to the risk of macronutrient, vitamin and mineral deficiencies in the diets of the examined women, it seems necessary to educate this group as well as caregivers and doctors in the area of nutrition adapted to the needs of the elderly.

Antioxidant Vitamins as Oxidative Stress Markers in Rat Plasma After Physical Exercise - a Short Report

Abstract The aim of the study was to verify the hypothesis that β-carotene, vitamin E, vitamin C administered individually or in combination may differently modify their levels in blood plasma being also markers of the oxidative stress. Male Wistar rats were supplemented antioxidants per os (α-to-copherol - 2 mg/d, ascorbic acid - 12 mg/d, β-carotene - 1 mg/d), both individually or in combination of 2 or 3, for 14 days. During experiment, half of the animals in each group (n=8) were subjected to treadmill exercise for 15 min at the speed of 20 m/min, to induce oxidative stress. Vitamins in rat plasma were assessed by the high-performance liquid chromatography (HPLC). Results suggest that vitamin E and C supplemented simultaneously may provide some benefit during physical exercise. The significant influence of administered α-tocopherol acetate and physical exercise on the level of α-tocopherol in the plasma was observed. Thus only the concentration of α-tocopherol in blood may be treated as a marker of oxidative stress.