Joanna Radin

Latent life: Concepts and practices of human tissue preservation in the International Biological Program

Before the rise of DNA sequence analysis or the controversies over the Human Genome Diversity Project, there was the International Biological Program, which ran from 1964 to 1974. The Human Adaptability arm of the International Biological Program featured a complex encounter between human geneticists and biological anthropologists. These scientists were especially interested in what could be learned from the bodies of people they referred to as both primitive and in danger of going extinct. In this article, I address how new access to technologies of cold storage, which would allow blood to be transported from the field to the lab and be stored for subsequent reanalysis, gave shape to this episode in Cold War human biology and has ramified into our genomic age. This case study highlights the importance of cryopreservation to projects of genetic salvage as well as to the life sciences, more generally. I argue that ‘latency’, a technical term initially used by cryobiologists to describe life in a state of suspended animation, can be extended as a concept for science studies scholars interested in technoscientific efforts to manage the future.

Indigenous body parts, mutating temporalities, and the half-lives of postcolonial technoscience

Biological samples collected from indigenous communities from the mid-20th century for scientific study and preserved in freezers of the Global North have been at the center of a number of controversies. This essay explores why the problem of indigenous biospecimens has returned to critical attention frequently over the past two decades, and why and how Science and Technology Studies should attend to this problem. We propose that mutation – the variously advantageous, deleterious, or neutral mechanism of biological change – can provide a conceptual and analogical resource for reckoning with unexpected problems created by the persistence of frozen indigenous biospecimens. Mutations transcend dichotomies of premodern/modern, pro-science/anti-science, and north/south, inviting us to focus on entanglements and interdependencies. Freezing biospecimens induces mutations in indigenous populations, in the scientists who collected and stored such specimens, and in the specimens themselves. The jumbling of timescales introduced by practices of freezing generates new ethical problems: problems that become ever more acute as the supposed immortality of frozen samples meets the mortality of the scientists who maintain them. More broadly, we propose that an ‘abductive’ approach to Science and Technology Studies theories of co-production can direct attention to the work of temporality in the ongoing alignment of social and technical orders. Attending to the unfolding and mutating vital legacies of indigenous body parts, collected in one time and place and reused in others, reveals the enduring colonial dimensions of scientific practice in our global age and demonstrates new openings for ethical action. Finally, we outline the articles in this special issue and their respective ‘mutations’ to postcolonial Science and Technology Studies, a field that, like genome science, is racked with ethical and temporal dilemmas of reckoning for the past in the present.

Unfolding epidemiological stories: How the WHO made frozen blood into a flexible resource for the future

In the decades after World War II, the World Health Organization (WHO) played an important role in managing the process of stabilizing collections of variable blood samples as a fundamentally unstable, protean, and unfolding biomedical resource. In this system, known and as yet unknown constituents of blood were positioned as relevant to the work of multiple constituencies including human population geneticists, physical anthropologists, and immunologists. To facilitate serving these and other constituencies, it was crucial to standardize practices of collecting and preserving samples of blood from globally distributed human populations. The WHO achieved this by linking its administrative infrastructure-comprised of expert advisory groups and technical reports-to key laboratories, which served as sites for demonstrating and also for disseminating standards for working with variable blood samples. The practices that were articulated in making blood samples into a flexible resource contributes to emerging histories of global health that highlight the centrality of new institutions, like the WHO, new forms of expertise, like population genetics and serological epidemiology, and new kinds of research materials, like frozen blood.

Bounding an Emerging Technology: Para-Scientific Media and the Drexler-Smalley Debate About Nanotechnology

‘Nanotechnology’ is often touted as a significant emerging technological field. However, determining what nanotechnology means, whose research counts as nanotechnology, and who gets to speak on behalf of nanotechnology is a highly political process involving constant negotiation with significant implications for funding, legislation, and citizen support. In this paper, we deconstruct a high-profile moment of controversy about nanotechnology’s possibilities: a debate between K. Eric Drexler and Richard Smalley published as a ‘point—counterpoint’ feature in 2003 in Chemical & Engineering News. Rather than treat the debate as a stand-alone episode of scientific controversy, we seek to understand the forces that enabled it to be seen as such an episode. We introduce the term ‘para-scientific’ media to make explicit how certain forms of publication intervene in the dissemination of technical knowledge as it travels beyond its supposed site of production. The existence of para-scientific media is predicated on intimate association with formalized channels of scientific publication, but they also seek to engage other cultures of expertise. Through this lens, we show that Drexler and Smalley were not only independent entrepreneurs enrolling Chemical & Engineering News as a site of boundary work; members of the para-scientific media actively enrolled Drexler and Smalley as part of a broader effort to simplify a complex set of uncertainties about nanotechnology’s potential into two polarized views. In this case study, we examine received accounts of the debate, describe the boundary work undertaken by Drexler and Smalley to shape the path of nanotechnology’s emergence, and unpack the boundary work of the para-scientific media to create polarizing controversy that attracted audiences and influenced policy and scientific research agendas. Members of the para-scientific media have been influential in bounding nanotechnology as a field-in-tension by structuring irreconcilable dichotomies out of an ambiguous set of uncertainties. We conclude with thoughts about the implications of this case study for studies of science communication, institutional entrepreneurship and the ethics of emerging technologies.

Indigenous biospecimen collections and the cryopolitics of frozen life

In the mid-20th century, scientists began to collect and freeze blood samples for a range of purposes. This article considers the broader implications of scientific freezing for conceptions of time and life by drawing on empirical research with scientists associated with a large collection of samples assembled from Indigenous Australians in the 1960s. We first review some key critiques of cryopreservation posed by Indigenous scholars and by science and technology studies. We then propose ‘cryopolitics’ as a concept to express the various political, ethical and temporal conundrums presented by the practice of freezing. We frame cryopolitics as a mode of Michel Foucault’s biopolitics. If biopolitical assemblages make live and let die, cryopolitical ones reveal the dramatic consequences of mundane efforts to make live and not let die. In our case study, we argue that frozen blood vacillates between two cryopolitical states, ‘latent life’ and ‘incomplete death’. Samples seen as latent life cannot be destroyed; samples understood as incomplete death require destruction. A state of incomplete death can be resolved through the return of blood samples to the Indigenous groups they were collected from, a process that has occurred in North America. Our cryopolitical analysis suggests another potential resolution: reviving a form of latent life aligned with futures envisaged by Indigenous communities themselves.

“Digital Natives”: How Medical and Indigenous Histories Matter for Big Data

This case considers the politics of reuse in the realm of “Big Data.” It focuses on the history of a particular collection of data, extracted and digitized from patient records made in the course of a longitudinal epidemiological study involving Indigenous members of the Gila River Indian Community Reservation in the American Southwest. The creation and circulation of the Pima Indian Diabetes Dataset (PIDD) demonstrates the value of medical and Indigenous histories to the study of Big Data. By adapting the concept of the “digital native” itself for reuse, I argue that the history of the PIDD reveals how data becomes alienated from persons even as it reproduces complex social realities of the circumstances of its origin. In doing so, this history highlights otherwise obscured matters of ethics and politics that are relevant to communities who identify as Indigenous as well as those who do not.

Patrons of the human experience : a history of the Wenner-Gren Foundation for Anthropological Research, 1941–2016

The Wenner-Gren Foundation for Anthropological Research has played a critical but little-understood role in the development of the social and biological sciences since 1941. For anthropology particularly, its programs have often helped redefine scholarly priorities and research trajectories. Its grants to doctoral students have functioned as an important early sign of scholarly legitimacy, a mark of belonging to the profession. The foundation’s history also reflects general transformations in scientific patronage as new landscapes of federal, military, and private funding reconfigured opportunities in the social sciences. In this account we track the evolution of the foundation in tandem with the evolution of anthropology during a period of dramatic change after 1941, looking at the Second World War context from which the foundation emerged and the ideas and experiences of those who played a key role in this history. We examine the long-term influence of a philanthropic foundation on the postwar emergence...

Human Genome Diversity Project: History

The Human Genome Diversity Project was intended to be a large-scale effort to sample and archive human genetic variation. It was initially proposed by geneticists and evolutionary biologists in the early 1990s and was soon met by strong criticism. These criticisms came from multiple fronts, including biological and cultural anthropologists as well as indigenous rights activists and community members. Project organizers, who identified as antiracist and uninterested in reaping commercial benefits, were surprised to learn that many of these critics perceived the project as racist and neocolonial. These concerns led the initiative to falter, particularly in the United States. While the Human Genome Diversity Project did not achieve its original aims, it demonstrated the need to attend to the intertwined ethical and epistemological challenges of investigating human difference in a genomic age.

Studying Mandela’s Children: Human Biology in Post-Apartheid South Africa

In this interview, human biologist Noel Cameron reflects on his work on child growth and development in post-apartheid South Africa. The conversation focuses in particular on Cameron’s involvement with a cohort study called Birth to Twenty, which sought to determine the health impacts of apartheid on black children born in the year Nelson Mandela became president. Cameron considers the extent to which human population biology can contribute to the creation of new and potentially improved health realities for marginalized communities in the Global South.