Joe Frisch

Oral surgery--oral pathology conference No. 18, Walter Reed Army Medical Center. Application of a new chemical adhesive in periodontic and oral surgery.

Abstract The present study deals with the clinical use of butyl cyanoacrylate (a chemical adhesive) as a periodontal and surgical dressing in man. The study, conducted in 105 patients in whom a total of 276 applications were made, reveals the following: 1. Butyl cyanoacrylate is a far better periodontal dressing than any in use at the present time. This conclusion is based on the fact that it is applied with great ease, is a hemostatic agent, is not bulky and therefore permits the use of prostheses, can be used around single teeth, reduces postoperative pain, usually requires only one application, does not induce overabundant granulation, and accelerates the healing process. 2. When applied on extraction sites, it produces immediate hemostasis. 3. Over large areas of mucosal ulceration produced in recurrent aphthae and leukemia, application of this adhesive produces transitory relief from pain and discomfort.

Effect of butyl cyanoacrylate on the healing of extraction wounds

Abstract This histologic study was conducted to determine the effect of butyl cyanoacrylate on the healing of extraction wounds. Ninety-six upper first molars were extracted in forty-eight adult rats. Half of the wounds were covered with a spray of butyl cyanoacrylate, while the other half were left uncovered. When animals were killed from 1 to 21 days postoperatively, it was found that the wounds protected with the cyanoacrylate spray consistently showed less inflammatory infiltrate than the control wounds. In addition, it appears that collagenization and epithelization probably occur faster in these treated wounds than in the control wounds. It is postulated that this material should be a valuable aid in the prevention of the so-called “dry socket.”

Tissue response of rat tongue to hexyl, heptyl, and octyl cyanoacrylate

Abstract This study deals with the tissue response of the incised rat tongue to three chemical adhesives—hexyl, heptyl, and octyl cyanoacrylates. Sixty-three rats were divided into three groups, their tongues were incised and approximated with these materials, and the animals were killed 1, 3, 5, 10, 14, 21, and 30 days postoperatively. Histologic analysis revealed the following: 1. 1. The tissue receptivity of the three adhesive materials was almost identical. 2. 2. The hexyl, heptyl, and octyl cyanoacrylates did not appear to be superior to the butyl cyanoacrylate. 3. 3. The rat tongues, showed the normal healing process, and the adhesive material was gradually removed from the site of application. This removal was brought about partly by sequestration and partly by phagocytosis. The material which persisted in the tissues was completely surrounded by histiocytes and foreign body giant cells.

Tissue Response to a Dental Cement Containing Butyl Cyanoacrylate

Tissue response to a mixture of butyl cyanoacrylate and calcium sulfate hemihydrate which polymerizes in the presence of saliva and forms a hard mass. In rat connective tissue, it produced a response which was comparable with the response to zinc oxide and eugenol.

Oral surgery—oral pathology conference No. 16, Walter Reed Army Medical Center

Abstract The present case concerns a solitary growth of the gingiva which appeared clinically to be a pyogenic granuloma but which, in fact, represented a reticulum-cell sarcoma. This malignant tumor was successfully treated by conservative excision. There was no recurrence in the oral cavity.