Johannes Schwerdtner

How should I decide? The neural correlates of everyday moral reasoning

The present fMRI study is the first that investigates everyday moral conflict situations in which a moral standard clashes with a personal desire. In such situations people have to decide between a morally guided and a hedonistic behaviour. Twelve healthy subjects were presented with verbal stories describing conflicts with either moral or neutral content. The moral stories described conflicts requiring a decision between a personal desire and a conflicting moral standard, whereas the neutral conflicts required a decision between two conflicting personal desires. When compared to neutral conflicts, moral conflicts elicited higher activity in a wide spread neural network including the medial frontal cortex, the temporal cortex and the temporo-parietal junction and the posterior cingulate cortex. Further analyses of the moral conflicts revealed that hedonistic decisions in contrast to morally guided decisions were associated with significantly higher rankings of uncertainty and unpleasant emotions and induced significant more activation in the amygdala/parahippocampal region. The present results generalise findings on the neuroscience of moral understanding by extending it to everyday moral decisions. Furthermore, the results show that the amydala region plays a central role in the processing of negative emotional consequences associated with immoral decisions.

Integration of emotion and cognition in patients with psychopathy.

Psychopathy is a personality disorder associated with emotional characteristics like impulsivity, manipulativeness, affective shallowness, and absence of remorse or empathy. The impaired emotional responsiveness is considered to be the hallmark of the disorder. There are two theories that attempt to explain the emotional dysfunction and the poor socialization in psychopathy: (1) the low-fear model and (2) the inhibition of violence model. Both approaches are supported by several studies. Studies using aversive conditioning or the startle modulation underline the severe difficulties in processing negative stimuli in psychopaths. Studies that explore the processing of emotional expressions show a deficit of psychopathic individuals for processing sad or fearful facial expressions or vocal affect. In the cognitive domain, psychopaths show performance deficits in the interpretation of the motivational significance of stimuli. Studies investigating the impact of emotions on cognitive processes show that in psychopaths in contrast to healthy controls negative emotions drain no resources from a cognitive task. It is suggested that dysfunctions in the frontal cortex, especially the orbitofrontal cortex, the cingulate cortex and the amygdala are associated with the emotional and cognitive impairments.

Cognitive Improvement of Schizophrenia Patients: Enhancing Cognition while Enjoying Computer-Aided Cognitive Training

Cognitive deficits are a core symptom in schizophrenia, but until now controlled efficacy studies of cognitive training methods have shown inconclusive results. This study examined the effects of c...