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Dive into the research topics where John D. Orr is active.

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Featured researches published by John D. Orr.


Journal of Chromatography B | 2003

Derivatization of phospholipids

Yonghui Wang; Ira S. Krull; Carrie Liu; John D. Orr

Phospholipids are major components of biological membranes. Without chemical derivatization, it is difficult to identify and quantitate phospholipids in biological samples. Chemical derivatization can improve both the selectivity and sensitivity of the analytes. This paper gives a full review, through March, 2002, of derivatization methods used for phospholipids in HPLC, CE and GC as well as the spray reagent used for TLC in the early days.


Organic Process Research & Development | 2015

Industry Perspectives on Process Analytical Technology: Tools and Applications in API Development

Arani Chanda; Adrian M. Daly; David A. Foley; Mark A. LaPack; Samrat Mukherjee; John D. Orr; George L. Reid; Thompson D; Howard W. Ward


Synlett | 2013

Commercial Manufacture of Halaven®: Chemoselective Transformations En Route to Structurally Complex Macrocyclic Ketones

Brian Austad; Trevor L. Calkins; Charles E. Chase; Francis G. Fang; Thomas E. Horstmann; Yongbo Hu; Bryan M. Lewis; Xiang Niu; Thomas A. Noland; John D. Orr; Matthew J. Schnaderbeck; Huiming Zhang; Naoki Asakawa; Naoki Asai; Hiroyuki Chiba; Takashi Hasebe; Yorihisa Hoshino; Hiroyuki Ishizuka; Takashi Kajima; Akio Kayano; Yuki Komatsu; Manabu Kubota; Hirofumi Kuroda; Mamoru Miyazawa; Katsuya Tagami; Tomohiro Watanabe


Synlett | 2013

Process Development of Halaven®: Synthesis of the C14–C35 Fragment via Iterative Nozaki–Hiyama–Kishi Reaction–Williamson Ether Cyclization

Brian Austad; Farid Benayoud; Trevor L. Calkins; Silvio Campagna; Charles E. Chase; Hyeong-wook Choi; William J. Christ; Robert Costanzo; James Cutter; Atsushi Endo; Francis G. Fang; Yongbo Hu; Bryan M. Lewis; Michael D. Lewis; Shawn McKenna; Thomas A. Noland; John D. Orr; Marc Pesant; Matthew J. Schnaderbeck; Gordon D. Wilkie; Taichi Abe; Naoki Asai; Yumi Asai; Akio Kayano; Yuichi Kimoto; Yuki Komatsu; Manabu Kubota; Hirofumi Kuroda; Masanori Mizuno; Taiju Nakamura


Archive | 2001

Separation of olefinic isomers

Lily Lu; John D. Orr


Organic Process Research & Development | 2015

Industry Perspectives on Process Analytical Technology: Tools and Applications in API Manufacturing

Shailendra Bordawekar; Arani Chanda; Adrian M. Daly; Aaron W. Garrett; John P. Higgins; Mark A. LaPack; Todd D. Maloney; James E. Morgado; Samrat Mukherjee; John D. Orr; George L. Reid; Bing-Shiou Yang; Howard W. Ward


Organic Process Research & Development | 2014

Part 1: A Review and Perspective of the Regulatory Guidance to Support Designation and Justification of API Starting Material

Margaret M. Faul; William F. Kiesman; Maciej Smulkowski; Steven Pfeiffer; Carl A. Busacca; Magnus Eriksson; Fred Hicks; John D. Orr


Organic Process Research & Development | 2014

Part 2: Designation and Justification of API Starting Materials: Current Practices across Member Companies of the IQ Consortium

Margaret M. Faul; Carl A. Busacca; Magnus Eriksson; Fred Hicks; William F. Kiesman; Maciej Smulkowski; John D. Orr; Steven Pfeiffer


Archive | 2010

Highly purified antiendotoxin compound

John D. Orr


Organic Process Research & Development | 2015

Part 3: Designation and Justification of API Starting Materials: Proposed Framework for Alignment from an Industry Perspective

Margaret M. Faul; Mark D. Argentine; Marjorie Egan; Magnus Eriksson; Zhihong Ge; Fred Hicks; William F. Kiesman; Ingrid Mergelsberg; John D. Orr; Maciej Smulkowski; Gerald A. Wächter

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Ira S. Krull

Northeastern University

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Magnus Eriksson

Chalmers University of Technology

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Yonghui Wang

Northeastern University

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