John H. Linehan
Marquette University
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Featured researches published by John H. Linehan.
Sleep | 2011
Jan B. Pietzsch; Abigail M. Garner; Lauren E. Cipriano; John H. Linehan
STUDY OBJECTIVES Obstructive sleep apnea (OSA) is a common disorder associated with substantially increased cardiovascular risks, reduced quality of life, and increased risk of motor vehicle collisions due to daytime sleepiness. This study evaluates the cost-effectiveness of three commonly used diagnostic strategies (full-night polysomnography, split-night polysomnography, unattended portable home-monitoring) in conjunction with continuous positive airway pressure (CPAP) therapy in patients with moderate-to-severe OSA. DESIGN A Markov model was created to compare costs and effectiveness of different diagnostic and therapeutic strategies over a 10-year interval and the expected lifetime of the patient. The primary measure of cost-effectiveness was incremental cost per quality-adjusted life year (QALY) gained. PATIENTS OR PARTICIPANTS Baseline computations were performed for a hypothetical average cohort of 50-year-old males with a 50% pretest probability of having moderate-to-severe OSA (apnea-hypopnea index [AHI] ≥ 15 events per hour). MEASUREMENTS AND RESULTS For a patient with moderate-to-severe OSA, CPAP therapy has an incremental cost-effectiveness ratio (ICER) of
Physics in Medicine and Biology | 1998
Roger H. Johnson; Hui Hu; Steven T. Haworth; Paul S. Cho; Christopher A. Dawson; John H. Linehan
15,915 per QALY gained for the lifetime horizon. Over the lifetime horizon in a population with 50% prevalence of OSA, full-night polysomnography in conjunction with CPAP therapy is the most economically efficient strategy at any willingness-to-pay greater than
Annals of Biomedical Engineering | 1994
Anne V. Clough; Amir Al-Tinawi; John H. Linehan; C. A. Dawson
17,131 per-QALY gained because it dominates all other strategies in comparative analysis. CONCLUSIONS Full-night polysomnography (PSG) is cost-effective and is the preferred diagnostic strategy for adults suspected to have moderate-to-severe OSA when all diagnostic options are available. Split-night PSG and unattended home monitoring can be considered cost-effective alternatives when full-night PSG is not available.
American Journal of Physiology-lung Cellular and Molecular Physiology | 1998
Marilyn P. Merker; Lars E. Olson; Robert D. Bongard; Meha K. Patel; John H. Linehan; Christopher A. Dawson
Detailed morphometric knowledge of the microvascular network is needed for studies relating structure to haemodynamic function in organs like the lung. Clinical volumetric CT is limited to millimetre-order spatial resolution. Since evidence suggests that small arterioles (50 to 300 micrometres) dominate pulmonary haemodynamics, we built a micro-CT scanner, capable of imaging excised lungs in 3D with 100 microm resolution, for basic physiology research. The scanner incorporates a micro-focal (3 microm) x-ray source, an xyz theta stage and a CCD-coupled image intensifier detector. We imaged phantoms and contrast-enhanced rat lungs, reconstructing the data with either the Feldkamp or the circle-and-line cone-beam reconstruction algorithm. We present reconstructions using 180 views over 360 degrees for the circular trajectory, augmented with views from a linear scan for the circle-and-line algorithm. Especially for platelike features perpendicular to the rotation axis and remote from the midplane, the circle-and-line algorithm produces superior reconstructions compared with Feldkamps algorithm. We conclude that the use of nonplanar source trajectories to perform micro-CT on contrast-enhanced, excised lungs can provide data useful for morphometric analysis of vascular trees, currently down to the 130 microm level.
Annals of Biomedical Engineering | 1998
Said H. Audi; John H. Linehan; Gary S. Krenz; Christopher A. Dawson
AbstractMethods for estimating regional flow from digital angiography or dynamic computed tomography images require determination of indicator mean transit time (
Pediatric Research | 1994
Leif D. Nelin; D. A. Rickaby; John H. Linehan; Christopher A. Dawson
Annals of Biomedical Engineering | 1998
Douglas A. Hettrick; Joseph H. Battocletti; James J. Ackmann; John H. Linehan; David C. Warltier
\bar t
Annals of Biomedical Engineering | 1996
Douglas A. Hettrick; Joseph H. Battocletti; James J. Ackmann; John H. Linehan; David C. Warltier
Journal of Medical Devices-transactions of The Asme | 2007
Jan B. Pietzsch; Lauren M. Aquino; Paul G. Yock; M. Elisabeth Paté-Cornell; John H. Linehan
) through a region-of-interest (ROI). We examine how the ROI kinematics and input dispersion influence the recovery of
Advances in pharmacology | 1994
David L. Roerig; Susan B. Ahlf; Christopher A. Dawson; John H. Linehan; John P. Kampine