John L. Giunta

Allergic contact stomatitis caused by acrylic resin

A llergic contact stomatitis caused by resins, particularly self-polymerizing resins, are rare or are rarely reported.*+ When allergic responses have been reported, the responsible agent appears to be residual monomer which is capable of producing a stomatitis and an angular cheilitis.‘, 6, 7 In a previous report of allergy to residual monomer it was suggested that the “cured” material could be treated to remove the residual monomer so that the restoration could still be used in the treatment of a sensitized patient without further adverse reacti0n.j In that report the patient had erythema multiforme, a symptom complex in which allergy is often the underlying cause. The following report concerns another patient who became sensitive to self-polymerizing resin when a permanent maxillary splint was made. The reaction was erythema multiforme, which was treated by removing the residual monomer. The diagnosis of allergy was corroborated by patch testing.

Allergic stomatitis caused by self-polymerizing resin☆

This is a fully documented case, including biopsy and patch testing, of a patient who was hypersensitive to self-polymerizing polymethyl methacrylate. On two occasions, a 24-year-old woman with a history of multiple allergies developed allergic reactions to temporary acrylic dental restorations. The lesions disappeared upon removal of the restorations. Microscopic findings were consistent with an allergic reaction. Patch testing confirmed that the allergen was the monomer and indicated methods of processing the self-polymerizing resin to allow it to become essentially nonreactive in a sensitized patient.

Prevalence and intraoral distribution of coronal and root caries in middle-aged and older adults.

This work describes the prevalence and intraoral distribution of coronal and root caries in 326 predominantly white, educated, middle-aged and older adults. Study participants were recruited from Tufts Geriatric Outreach Program, Nutritional Status Study (NSS), and the Forsyth Root Caries Study. Eighty-five percent of participants reported visiting their dentist in the last year. The median number of teeth was 21 in the 65+ age-group, and 40% of participants had coronal caries and 33% had root carious lesions. The mean coronal and root caries (DFS) was higher and the proportion of decayed surfaces to all decayed and filled surfaces (%D/DFS) was lower than in other comparable studies. A comparative analysis of intraoral distribution of coronal and root caries and their relation with age is discussed.

Lymphoepithelial cysts of the oral mucosa.

Abstract Twenty-one cases of biopsied lesions diagnosed as lymphoepithelial cyst have been reported. With no predilection for either sex, these rare lesions occurred primarily in the floor of the mouth as small, nodular, asymptomatic swellings of unknown duration and were interpreted most often as mucoceles. They were excised and none recurred. Histologically, the small cysts were lined with stratified squamous epithelium which was surrounded by lymphoid tissue with follicles. Although the cause is uncertain, both the proliferation of entrapped ductal epithelium in ectopic lymphoid tissue and the obstruction of a tonsillar crypt may give rise to lymphoepithelial cysts.

Atypical central neurilemmoma of the mandible

Neurilemmomas arising within the jawbones are rare. Most occur in the mandible as slowly growing enlargements that may or may not be painful; radiographically, they are large single or multiloculated radiolucencies mimicking other benign jaw lesions. The histology is characteristic, with Antoni A and B tissues and a well-defined capsule. This article reports an unencapsulated neurilemmoma of the mandible and reviews and summarizes the features of the central neurilemmomas in the literature.

Peripheral, soft tissue odontomas

Two cases of rare, peripheral, soft tissue odontomas, in different growth phases, are reported. Case one, discovered in an early, rapid growth phase, had no radiographic appearance, was presumed to be a periodontal abscess, and presented a diagnostic challenge. Case two was diagnosed radiographically in its mature phase. Both were treated successfully by excisional biopsy and did not recur. Comparisons are made to the classic intrabony odontomas.

Congenital granular-cell tumor of alveolar ridge and tongue: Report of two cases

Granular-cell tumors in the oral cavity occur primarily on the tongue (myoblastoma) in adults and on the gum pads (congenital epulis) in infants. Because of the usual location and age, these histologically and histochemically similar tumors have been separate clinical entities. These case reports, however, report the concurrence of both clinical entities in the same patient. A 7-day-old female infant had a 1 cm. epulis on the right anterior maxilla and two 1.5 mm. masses on the anterior ventrum of the tongue. A 12-day-old girl had a 1 cm. epulis on the anterior mandible and two 1.5 mm. masses on the anterior tongue near the tip. In both cases, all lesions were histologically and histochemically similar and were granular-cell tumors. This suggests a relationship in the origin of these entities and tends to rule out an odontogenic origin for the epulis.

The effect of antilymphocyte serum on experimental hamster buccal pouch carcinogenesis

Abstract The effect of systemically injected anti-hamster lymphocyte serum (ALS) on chemical carcinogenesis of the buccal pouch has been studied in thirty Syrian hamsters. In ten animals the right buccal pouch was painted with a 0.5 per cent solution of 9,10-dimethyl-1,2-benzanthracene (DMBA) in heavy mineral oil. Ten animals were painted with DMBA and also injected intraperitoneally with 0.45 ml. of ALS. The remaining ten animals served as untreated controls. There was a higher incidence of carcinoma in the ALS DMBA group and a suggestion of earlier tumor development. Histologically, the ALS DMBA group presented a consistent tumor pattern with more deep invasion and more anaplasticity than the control group. The pouches of the ALS DMBA group were more extensively involved in the development of neoplastic changes.

Dental changes in hypervitaminosis D

Vitamin D is required for the normal development of teeth and bones. When there is excess vitamin D, systemic and dental changes may occur. This is a case report of a girl who experienced hypercalcemia secondary to excess vitamin D derived from the consumption of milk that was incorrectly fortified. The changes in the permanent dentition to date are enamel hypoplasia and focal pulp calcification. These changes correspond to the timing of the toxemia caused by hypervitaminosis D.

The effect of 13-cis-retinoic acid on hamster buccal pouch carcinogenesis

In order to determine whether 13-cis-retinoic acid, an analog of vitamin A, has antitumor activity in an oral cancer model system, the following study was undertaken. Fifty-three adult hamsters were divided into four groups. Group 1 was tested with a 0.5 percent solution of 9,10-dimethyl-1,2-benzanthracene (DMBA) in heavy mineral oil, which was painted on the right buccal pouch three times per week for 12 weeks. Group 2 received DMBA plus 13-cis-retinoic acid (RA) incorporated into gelatinized beadlets and mixed with a powdered commercial diet (dosage, 300 mg per kilogram of diet). Group 3 received only RA; Group 4 received a placebo. The animals were killed at 6, 12, and 18 weeks and tissues were studied clinically and histologically in a routine manner. Results show that all groups receiving DMBA developed epidermoid carcinomas. However, there were several other changes. In the RA-treated animals, particularly those treated with DMBA, there was an ingrowth of surface epithelium with development of ductal structures in the buccal pouch. There were changes in surface epithelium, and there were dense aggregates of lymphoid tissue with development of exophytic nodules suggestive of lymphoma. Animals fed RA showed a relative weight loss. The findings suggest that there was a hypervitaminosis A state yielding prominent epithelial metaplastic changes but not affecting the progression or production of carcinoma.