Edmund Cataldo

Lymphoepithelial cysts of the oral mucosa.

Abstract Twenty-one cases of biopsied lesions diagnosed as lymphoepithelial cyst have been reported. With no predilection for either sex, these rare lesions occurred primarily in the floor of the mouth as small, nodular, asymptomatic swellings of unknown duration and were interpreted most often as mucoceles. They were excised and none recurred. Histologically, the small cysts were lined with stratified squamous epithelium which was surrounded by lymphoid tissue with follicles. Although the cause is uncertain, both the proliferation of entrapped ductal epithelium in ectopic lymphoid tissue and the obstruction of a tonsillar crypt may give rise to lymphoepithelial cysts.

Osteoma of the Tongue

True osteomas occur rather frequently in the bones of the skull and involve the sinus cavities. Osteoma of the tongue is a rare condition. Seven cases have previously been reported. The eighth case is now presented. REPORT OF CASE Mrs. M. W., a white housewife, age 30, was admitted to the migraine clinic of Montefiore Hospital, on Dec. 23, 1946. Her chief complaints were headache, postnasal discharge and a tendency to gag and vomit. These had been present for several months. There was no history of pain or difficulty in swallowing. On Jan. 23, 1947, she was referred to the ear, nose and throat clinic for consultation. At that time the patient stated that six days previously she had felt with her finger a mass at the back of her throat. Examination revealed no abnormalities except of the tongue. At the middle of the right limb of the V formed

Multiple dental follicles with odontogenic fibroma-like changes (WHO type)

A 15-year-old boy, in the case presented in this article, had 13 unerupted teeth, each associated with hyperplastic pericoronal tissue that showed histologic features suggestive of the WHO type of odontogenic fibroma. The etiology, clinical features, radiographic findings, and histopathology of the odontogenic fibroma are reviewed. It is suggested that the unusual pericoronal findings represent a hamartomatous change.

Oral hairy leukoplakia with extensive oral mucosal involvement: Report of two cases

Oral hairy leukoplakia (HL) is a lesion that occurs predominantly on the tongue in HIV-infected persons. Evidence strongly indicates that HL is related to the presence of Epstein-Barr virus in the epithelial cells. The lesion appears on the lateral border of the tongue as a painless, white plaque varying in size from a few millimeters to extensive lingual involvement. Histopathologically, the characteristic findings are hyperparakeratosis, hyperplasia, and ballooning of prickle cells resembling koilocytosis. HL is now considered a frequent, early, and specific sign of HIV infection and a strong indicator that AIDS will develop in the patient. We report on two cases of HL with marked oral mucosal involvement with extension to the pharyngeal mucosa.

Solitary and multiple plasma-cell tumors of the jaws and oral cavity☆

S olitary plasma-cell tumors are rare lesions which may occur in bone or soft tissue. Primary soft-tissue plasma-cell tumors ca,n occur in many tissues and organs, but they are more commonly found in the upper air passages and the oral cavity.4p 6, 9, lo, I6 Extramedullary plasmacytomas may have a variety of clinical appearances, but they are usually described as pedunculated or sessile, red or gray-red masses on the mucosa. The relationship between solitary plasma-cell tumors and multiple myeloma is rather confusing. Multiple myeloma is usually a fatal disease that runs its course in about 2 years.l, I3 It is a malignant neoplasm of bone marrow which is thought to arise from reticuloendothelial cells* and to be multifocal in origin, rather than a metastasis from a primary lesion.5, 6 Clinically, symptoms usually include severe pain and occasional pathologic fracture due to bone destruction. A high percentage of persons affected with this condition exhibit hyperglobulinemia with reversal of the albumin-globulin ratio, anemia, and Bence-Jones protein in the urine. Histologically, multiple myeloma may consist of sheets of densely packed cells which are uniform in size and closely resemble plasma cells. In some instances, the microscopic picture reveals cells which tend to be larger than the normal plasma cells, with multinucleated cell forms a,nd numerous mitoses. The solitary plasma-cell tumor is usually histologically indistinguishable from the multiple plasma-cell myeloma. 7 However, the solitary plasma-cell tumors have a much better prognosis, and most cases do not show the hematologic, chemical, and radiographic changes associated with mult.iple myeloma. Some documented cases however, have been followed for many years and have sub-

Experimental Carcinogenesis in Duct-Artery Ligated Rat Submandibular Gland

This study compared tumor induction time and the type of tumor formed in rat submandibular glands implanted with 9,10-dimethyl-1,2-benzanthracene (DMBA) to glands ligated before implantation of DMBA. Results showed no difference in tumor induction time or the type of tumor formed.

Cementoblastoma involving multiple deciduous teeth

The first case of a cementoblastoma involving multiple mandibular deciduous incisors is presented. The clinical, radiographic, and histopathologic features of the cementoblastoma are reviewed. The possible etiology for the pain frequently associated with this lesion is discussed.

Atypical lymphohistiocytic infiltrate (pseudolymphoma) of the oral cavity

In the oral cavity, differentiation between reactive and neoplastic lymphoproliferative lesions can, at times, be very difficult. We report an unusual case in which immunohistochemical findings were necessary to determine that the lesion was reactive despite the original interpretation of malignant lymphoma. The relationship of this lesion to atypical histiocytic granuloma, angiolymphoid hyperplasia with eosinophilia, and traumatic ulcerative granuloma with stromal eosinophilia is discussed and possible pathogenetic mechanisms are proposed. The value of immunohistochemistry in the diagnosis of extranodal lymphoproliferative lesions is emphasized.

The effect of systemically administered cortisone on salivary-gland carcinogenesis in the rat.

Fortv albino rats, 3-4 months of age, were divided into four groups, each consisting of five males and five females. The animals of Group)s 1 and 2 had Jellcts of dinmethylIbenzanthracene (I)MBA) im1slanted into the right submaxillary gland according to the technique of Cataldo and Shklar (J. dent. Res., 43:568-79, 1964). The animals were separated according to sex and fed a standard laboratory diet. Animals of Group I served as DMBA controls. Two weeks after the start of the experiment, aninials of Groups 2 and 3 were given daily 0.5-mg. parenteral injections of cortisone acetate. Animals of Group 3 served as cortisone controls. Eight weeks after the start of the experiment, half the animals were sacrificed. The other half were sacrificed after 12 weeks. The salivary glands were separated, and the pellet of DMBA was removed from the right submaxillary gland of the animals in GCroups 1 and 2. The glands were placed in 10 per cent formalin for 48 hours, sectioned in paraffin at 6 A and stained with hematoxylin and eosin. Implantation of DMBA pellets into the submaxillary glands resulted in a wide variety of cellular alterations, ranging from metalplasia to ncoplasia. Follow ing initial inflammatory changes, there were the development of epidermoid cysts and the transformation of the cyst epithelium to epidermoid carcinomas. Those animals receiving cortisone developed carcinomas more rapidly and in larger numbers than the DMBA controls. The difference could not be clearly discerned at 8 weeks, but at 12 weeks the DMBA-cortisone group had developed frank malignancies in six animals, while the DMBA controls had developed one malignancy. Furthermore, the development of dy skeratotic alterations was more pronounced in the DMBA-cortisone group (Figs. 1 and 2).

Pulp Reaction to a Resin-Bonded Quartz Composite Material

Pulp responses induced by a resin-bonded quartz composite material, with and without liners, were compared with those induced by zinc oxide-eugenol at 7, 28, and 84 days after Class V cavity preparations were made in 96 intact dog teeth. Only the unlined composite material elicited a significant inflammatory response.