John M. Smith

Teresa M. Foy; Jeannette Bannink; Robert A Sutherland; Patricia D. Mcneill; Garner G Moulton; John M. Smith; Martin A. Cheever; Kenneth H. Grabstein

The present study utilizes an in vivo murine tumor expressing human Her-2/neu to evaluate potential Her-2/neu vaccines consisting of either full length or various subunits of Her-2/neu delivered in either protein or plasmid DNA form. Our results demonstrate that protective immunity against Her-2/neu-expressing tumor challenge can be achieved by vaccination with plasmid DNA encoding either full length or subunits of Her-2/neu. Partial protective immunity was also observed following vaccination with the intracellular domain (ICD), but not extracellular domain (ECD), protein subunit of Her-2/neu. The mechanism of protection elicited by plasmid DNA vaccination appeared to be exclusively CD4 dependent, whereas the protection observed with ICD protein vaccination required both CD4 and CD8 T cells.

Monica Lik-Shing Tsang; Li Zhou; Bo-Ling Zheng; Jeff Wenker; Greg Fransen; John Humphrey; John M. Smith; Maureen O'Connor-McCourt; Roger Lucas; James A. Weatherbee

Tony N. Frudakis; John M. Smith; Steven G. Reed

Steven G. Reed; Yasir A. W. Skeiky; Michael J. Lodes; Raymond L. Houghton; John M. Smith; Patricia D. Mcneill

Kirsten Kitchin; Gaofeng Lin; Weilin L. Shelver; Michael P. Murtaugh; Paul R. Pentel; Susan M. Pond; Janelle C. Oberst; John Humphrey; John M. Smith; Michael C. Flickinger

Steven G. Reed; Yasir A. W. Skeiky; Michael J. Lodes; Raymond L. Houghton; John M. Smith; Patricia D. Mcneill

Steven G. Reed; Yasir A. W. Skeiky; Michael J. Lodes; Raymond L. Houghton; John M. Smith; Patricia D. Mcneill

Steven G. Reed; Yasir A. W. Skeiky; Michael J. Lodes; Raymond L. Houghton; John M. Smith; Patricia D. Mcneill

Raymond L. Houghton; Michael J. Lodes; Patricia D. Mcneill; Steven G. Reed; Yasir A. W. Skeiky; John M. Smith

Steven G. Reed; Yasir A. W. Skeiky; Michael J. Lodes; Raymond L. Houghton; John M. Smith; Patricia D. Mcneill