John M. Smith | Researchain

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Featured researches published by John M. Smith.

Vaccine | 2001

Vaccination with Her-2/neu DNA or protein subunits protects against growth of a Her-2/neu-expressing murine tumor

Teresa M. Foy; Jeannette Bannink; Robert A Sutherland; Patricia D. Mcneill; Garner G Moulton; John M. Smith; Martin A. Cheever; Kenneth H. Grabstein

The present study utilizes an in vivo murine tumor expressing human Her-2/neu to evaluate potential Her-2/neu vaccines consisting of either full length or various subunits of Her-2/neu delivered in either protein or plasmid DNA form. Our results demonstrate that protective immunity against Her-2/neu-expressing tumor challenge can be achieved by vaccination with plasmid DNA encoding either full length or subunits of Her-2/neu. Partial protective immunity was also observed following vaccination with the intracellular domain (ICD), but not extracellular domain (ECD), protein subunit of Her-2/neu. The mechanism of protection elicited by plasmid DNA vaccination appeared to be exclusively CD4 dependent, whereas the protection observed with ICD protein vaccination required both CD4 and CD8 T cells.

Cytokine | 1995

Characterization of recombinant soluble human transforming growth factor-β receptor Type II (rhTGF-βsRII)

Monica Lik-Shing Tsang; Li Zhou; Bo-Ling Zheng; Jeff Wenker; Greg Fransen; John Humphrey; John M. Smith; Maureen O'Connor-McCourt; Roger Lucas; James A. Weatherbee

Archive | 1998

Compositions and methods for the treatment and diagnosis of breast cancer

Tony N. Frudakis; John M. Smith; Steven G. Reed

Archive | 1997

Compounds and methods for the detection and prevention of t. cruzi infection

Steven G. Reed; Yasir A. W. Skeiky; Michael J. Lodes; Raymond L. Houghton; John M. Smith; Patricia D. Mcneill

Journal of Pharmaceutical Sciences | 1995

Cloning, Expression, and Purification of an Anti‐Desipramine Single Chain Antibody in NS/O Myeloma Cells

Kirsten Kitchin; Gaofeng Lin; Weilin L. Shelver; Michael P. Murtaugh; Paul R. Pentel; Susan M. Pond; Janelle C. Oberst; John Humphrey; John M. Smith; Michael C. Flickinger

Archive | 2000