John N. Graber

Video-assisted versus open anterior lumbar spine fusion surgery: a comparison of four techniques and complications in 135 patients.

Study Design. A retrospective review involved 135 patients undergoing anterior interbody fusion using four different approaches: transperitoneal video-assisted surgery with insufflation, retroperitoneal endoscopic video-assisted surgery, minilaparotomy retroperitoneal surgery, and traditional oblique muscle-splinting retroperitoneal surgery. Objective. To describe and compare the operative procedure and perioperative complications of four different interbody fusion techniques. Summary of Background Data. Although anterior lumbar interbody fusion surgery has a long history, several new and innovative approaches have been introduced recently. In contrast to the traditional oblique muscle-splitting retroperitoneal flank incision, the following have been used: a “minilaparotomy” open extraperitoneal approach through a small midline incision, a transperitoneal video-assisted insufflation technique, and a video-assisted gasless retroperitoneal endoscopic technique. Methods. A retrospective review was performed using the hospital records, operating room records, and clinic charts of 135 consecutive patients (50 men and 85 women) who underwent surgery between December 1993 and February 1998. Cases were included if either bone grafts alone or cylindrical cages with bone graft inside were used. Cases with anterior instrumentation using plates or rods were excluded. Diagnoses included degenerative disc disease, spondylolisthesis, or pseudarthrosis of a previous lumbosacral fusion. Patients with tumors or infection were excluded. The patients all were adults ranging in age from 17 to 83 years. Among the 135 patients, 12 had undergone previous anterior spine fusion surgery and 64 had undergone prior abdominal surgery. Results. The onset of new radicular pain or numbness, not experienced by the patient before surgery, occurred in six patients (18%; all with transperitoneal video-assisted surgery using insufflation). Vascular problems occurred in five patients (3.7% overall): two in the transperitoneal video-assisted group (5.9% of the group) and three in the minilaparotomy group (8.7% of the group). Retrograde ejaculation occurred in 4 of the 50 male patients (8% of the group): three in the transperitoneal video-assisted group (25% of the group) and one in the minilaparotomy group (2% of the group). Two patients had ureteral injuries (1.5% overall): one each in the retroperitoneal endoscopic and minilaparotomy groups. Conversion to open procedures was performed in seven patients (11% of the video-assisted procedures). The reasons for conversion included two major vessel lacerations and five peritoneal tears in the retroperitoneal video-assisted group. Conclusions. A comparative analysis of four techniques for approaching the lower lumbar spine to perform arthrodesis in 135 patients showed an incidence of complications consistent with the literature for video-assisted techniques, but higher than for open techniques. For these and other reasons, the video-assisted approaches have been abandoned by the surgeons of this report.

Outcomes Related to Antiplatelet or Anticoagulation Use in Patients Undergoing Carotid Endarterectomy

BACKGROUND The number of cases involving patients undergoing vascular procedures who are prescribed clopidogrel or warfarin as treatment options continues to rise. Our aim was to examine outcomes related to antiplatelet or anticoagulation therapy in patients undergoing carotid endarterectomy (CEA). METHODS A retrospective review of 260 consecutive patients undergoing CEA. Data including patient demographics, operative details, perioperative use of aspirin (ASA), clopidogrel, or warfarin, and early and/or late outcome(s) were collected. Endpoints included postoperative morbidity and/or mortality rate(s) and bleeding complications. RESULTS The study included 152 men and 108 women (mean age = 69.3 years), with a mean follow-up of 406 days. In all, 46% of endarterectomies were for a symptomatic disease. The technique of eversion endarterectomy was applied in 126 (48.5%), Dacron-patch in 112 (43.1%), and bovine pericardial-patch in 14 (5.4%) of the cases. Among the patients, 171 were taking ASA, 50 were taking clopidogrel ± ASA, and 10 were taking warfarin (mean INR = 1.62; range, 1.2-2.1); the remaining 29 were not on any antiplatelet therapy. All patients who were on warfarin therapy underwent an eversion endarterectomy. Overall, there were 19 (7.3%) complications (12 major and seven minor). The 30-day stroke rate and stroke death rate was 0.7% and 1.1%, respectively. Patients taking clopidogrel developed more number of neck hematomas (16% vs. 1.7%, p = 0.0004) compared with patients who were on ASA alone. For patients taking clopidogrel, Dacron-patch repair resulted in more hematomas than eversion endarterectomy (35% vs. 4.2%, p = 0.012). There was no difference in the incidence of neck hematoma on the basis of endarterectomy technique in patients who were on ASA alone. The patients taking warfarin neither had a perioperative complication nor developed a neck hematoma. CONCLUSIONS In this study, clopidogrel use during CEA resulted in a significant risk for developing a neck hematoma, particularly when using a Dacron-patch. The risk of a neck hematoma in patients who were on clopidogrel was much less when an eversion endarterectomy was performed.

The use of spinal cord stimulation for severe limb-threatening ischemia: a preliminary report

Spinal cord stimulation has been shown to control ischemic pain. We have applied spinal cord stimulation to nine patients with rest pain, non-healing ulceration, or digital gangrene to evaluate its effect on limb salvage. The patients had a mean age of 69 years. Six were diabetic, and all had previous major complications of their atherosclerotic disease. Stimulation was obtained by placing an electrode on the spinal cord under local anesthesia. Seven patients experienced marked reduction in their ischemic pain immediately after stimulation. These patients also had improved healing of ulcers documented by direct measurement. No significant change in ankle/brachial Doppler indices could be measured in any patient. One patient became suddenly worse and required amputation after one year of good pain relief and ulcer improvement. Two patients were not helped and went on to amputation within one month of stimulation. We conclude from these preliminary data that spinal cord stimulation effectively relieves ischemic pain and is associated with improved ulcer healing.

Hyperbaric Oxygen Treatment Outcome for Different Indications from a Single Center

BACKGROUND Hyperbaric oxygen (HBO) is used as an adjunctive therapy for a variety of indications. However, there is a lack of high-quality research evaluating HBO treatment outcomes for different indications available in the current literature. METHODS We retrospectively reviewed all patients who underwent HBO therapy at a single hyperbaric center from January 2010 to December 2013 using predetermined criteria to analyze successful, improved, or failed treatment outcomes for the following indications: chronic refractory osteomyelitis, diabetic foot ulcer, failed flap or skin graft, osteoradionecrosis, soft tissue radiation necrosis, and multiple coexisting indications. RESULTS Among the included 181 patients treated with adjunctive HBO at our center, 81.8% had either successful or improved treatment outcomes. A successful or improved outcome was observed in 82.6% of patients treated for chronic refractory osteomyelitis (n = 23), 74.1% for diabetic foot ulcer (n = 27), 75.7% for failed flap or skin graft (n = 33), 95.7% for osteoradionecrosis (n = 23), 88.1% for soft tissue radiation necrosis (n = 42), and 72.4% for multiple coexisting indications (n = 29). Among 4 patients treated for other indications, 100% of the cases were either successful or improved. CONCLUSIONS This study has provided a comprehensive outcome survey of using HBO for the previously mentioned indications at our center. It supplements the literature with more evidence to support the consideration of HBO in different indications.

Laser laparoscopic vagotomy and pyloromyotomy

We performed bilateral truncal vagotomy and gastric drainage procedure using standard laparoscopic instruments in five mongrel dogs. The procedure consisted of a transthoracic thoracoscopic bilateral truncal vagotomy and transperitoneal laparoscopic pyloromyotomy. A contact Nd:YAG laser fiber was used. There was no mortality, minimal morbidity, and post-operative gastric emptying was satisfactory. Pathologic studies indicated vagotomy was complete. We believe that this may be the initial step in the development of a simple, safe, and effective endoscopic procedure for the treatment of peptic ulcer disease.

Experimental transperitoneal laparoscopic pyloroplasty.

Interest in laparoscopic abdominal surgery continues to grow, which has persuaded a number of centers to pursue actively laparoscopic techniques that will allow surgeons to perform additional operative procedures in a less invasive manner. Peptic ulcer surgery, because of the morbidity associated with gastric surgery as well as the pain and discomfort associated with any major abdominal operation, has been largely replaced by pharmacologic therapy. As a result, patients are often advised to continue drug therapy indefinitely. This form of therapy, however, often only partially relieves the symptoms associated with peptic ulcer disease and leaves the patient at risk to develop life-threatening complications such as bleeding and perforation. Therefore, the rapid advances occurring in the field of laparoscopic surgery provide a fertile area for the development of simple, safe, and effective procedures to treat peptic ulcer disease in selected patients. A variety of different peptic ulcer operations have already been successfully performed under laparoscopic guidance. This report describes an experimental technique of transperitoneal stapled laparoscopic pyloroplasty using a modified end-to-end anastomotic stapling device (EEA Stapler; United States Surgical Corporation, Norwalk, CT, U.S.A.). The feasibility of this procedure was documented by detailed histologic evaluation of the pyloroplasty and revealed that the pyloric musculature had been excised, resulting in a true gastroduodenostomy. Pyloroplasty, coupled with either transabdominal or transthoracic vagotomy, could be a simple alternative to more extensive open abdominal surgery. This procedure represents one additional step in providing the practicing surgeon with the ability to perform a variety of different ulcer operations in a minimally invasive (laparoscopic) fashion.

Polyarteritis nodosa-induced pancreaticoduodenal artery aneurysmal rupture.

Polyarteritis nodosa (PAN) is a systemic, necrotizing vasculitis of small- and medium-sized arteries typically with multiorgan involvement. Most cases of PAN are idiopathic, although hepatitis B or C virus infections and hairy cell leukemia are important in the pathogenesis of some cases. PAN is characterized as segmental transmural inflammation of muscular arteries. Diagnosis is based on clinical suspicion, a negative immunofluorescence test for antineutrophil cytoplasmic antibodies, and whenever possible, biopsy conformation. Angiographic images may reveal microaneurysms affecting the renal, hepatic, or mesenteric vasculature. Aneurysmal formation and rupture are important complications that can be fatal. Treatment may warrant immunosuppression with steroids and cyclophosphamide. If left untreated, PAN can be fatal. To our knowledge, we report the second documented case of PAN-induced ruptured inferior pancreaticoduodenal artery aneurysm.

Arterial Embolisms and Thrombosis in Upper Extremity Ischemia

Objective: Upper extremity ischemia (UEI) is an uncommon condition that can lead to permanent disability. There is a limited understanding of the etiology, management, and outcomes of the disease. Methods: We retrospectively reviewed the charts of all patients who were diagnosed with “embolism and/or thrombosis of arteries of upper extremity” at our institution from January 2005 to December 2013. Results: Patients diagnosed with embolisms were older (P < .001), more likely to undergo thromboembolectomy (P < .001), had higher rates of hypertension (P = .001), and had longer lengths of hospital stay (P = .002). There were no significant differences in complications or mortality at 30 days and up to 1 year. Conclusion: At our center, embolism was found to be the most common etiology for UEI followed by thrombosis and stenosis. Patients presented with embolism were older, were more likely to undergo thromboembolectomy, and had higher rates of hypertension and longer hospital stays.