John Nolan
Norfolk and Norwich University Hospital
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Journal of Bone and Joint Surgery-british Volume | 2009
B. Ollivere; Clare Darrah; T. Barker; John Nolan; M. J. Porteous
The rate and mode of early failure in 463 Birmingham hip resurfacings in a two-centre, multisurgeon series were examined. Of the 463 patients two have died and three were lost to follow-up. The mean radiological and clinical follow-up was for 43 months (6 to 90). We have revised 13 resurfacings (2.8%) including seven for pain, three for fracture, two for dislocation and another for sepsis. Of these, nine had macroscopic and histological evidence of metallosis. The survival at five years was 95.8% (95% confidence interval (CI) 94.1 to 96.8) for revision for all causes and 96.9% (95% CI 95.5 to 98.3) for metallosis. The rate of metallosis related revision was 3.1% at five years. Risk factors for metallosis were female gender, a small femoral component, a high abduction angle and obesity. We do not advocate the use of the Birmingham Hip resurfacing procedure in patients with these risk factors.
Skeletal Radiology | 2011
Helen Anderson; Andoni P. Toms; John G. Cahir; Richard W. Goodwin; James Wimhurst; John Nolan
IntroductionMetal-on-metal (MoM) soft tissue reactions or aseptic lymphocytic vasculitis-associated lesions (ALVAL) are being recognised using metal artefact reduction (MAR) MR with increasing frequency following the advent of second generation metal-on-metal bearings, but there is no standardised technique for reporting of MR appearances in this disease. The aim of this study was to measure the reliability of a grading system designed for scoring the severity of MoM disease on MRI.Materials and methodsMRI examinations of 73 hips in 59 patients were retrospectively selected and then anonymised, randomised and reviewed by three independent observers (musculoskeletal radiologists). Each MR examination was scored as either A: normal, B: infection, C1: mild MoM disease, C2: moderate MoM disease or C3: severe MoM disease according to pre-defined criteria. Kappa correlation statistics were used to compare the observations.ResultsThere was substantial agreement among all three observers; the correlation coefficient between the two most experienced observers was κ = 0.78 [95% confidence intervals (CI): 0.68–0.88] and when compared with the least experienced observer coefficients were κ = 0.69 (95% CI: 0.57–0.80) and κ = 0.66 (95% CI: 0.54–0.78). The strongest correlation occurred for grades A, C2 and C3. The weakest correlations occurred for grades B and C1.ConclusionThe grading system described in this study is reliable for evaluating ALVAL in MoM prostheses using MR but is limited in differentiating mild disease from infection.
Journal of Bone and Joint Surgery-british Volume | 2010
Simon T. Donell; Clare Darrah; John Nolan; J. A. Wimhurst; Andoni P. Toms; T. Barker; C. P. Case; J.K. Tucker
Metal-on-metal total hip replacement has been targeted at younger patients with anticipated long-term survival, but the effect of the production of metal ions is a concern because of their possible toxicity to cells. We have reviewed the results of the use of the Ultima hybrid metal-on-metal total hip replacement, with a cemented polished tapered femoral component with a 28 mm diameter and a cobalt-chrome (CoCr) modular head, articulating with a 28 mm CoCr acetabular bearing surface secured in a titanium alloy uncemented shell. Between 1997 and 2004, 545 patients with 652 affected hips underwent replacement using this system. Up to 31 January 2008, 90 (13.8%) hips in 82 patients had been revised. Pain was the sole reason for revision in 44 hips (48.9%) of which 35 had normal plain radiographs. Peri-prosthetic fractures occurred in 17 hips (18.9%) with early dislocation in three (3.3%) and late dislocation in 16 (17.8%). Infection was found in nine hips (10.0%). At operation, a range of changes was noted including cavities containing cloudy fluid under pressure, necrotic soft tissues with avulsed tendons and denuded osteonecrotic upper femora. Corrosion was frequently observed on the retrieved cemented part of the femoral component. Typically, the peri-operative findings confirmed those found on pre-operative metal artefact reduction sequence MRI and histological examination showed severe necrosis. Metal artefact reduction sequence MRI proved to be useful when investigating these patients with pain in the absence of adverse plain radiological features.
Acta Biomaterialia | 2012
A. J. Hart; Paul D. Quinn; Ferdinand Lali; Barry Sampson; John A. Skinner; Jonathan J. Powell; John Nolan; Keith Tucker; Simon T. Donell; Adrienne M. Flanagan; J. Fred W. Mosselmans
Some types of metal-on-metal (MOM) hip replacements have unacceptably high rates of failure, such as the Ultima TPS MOM hip, with 13.8% failure at 5 years. This has been attributed to an inflammatory reaction following the release of cobalt (Co) and chromium (Cr) from the bearing surfaces and modular junctions. There is in vitro evidence that Co is more important than Cr in the inflammatory process, but there are no reported human tissue studies of the analysis of implant-derived metals.
Journal of Bone and Joint Surgery-british Volume | 2013
D. Ebreo; P. J. Bell; H. Arshad; Simon T. Donell; Andoni P. Toms; John Nolan
Metal artefact reduction (MAR) MRI is now widely considered to be the standard for imaging metal-on-metal (MoM) hip implants. The Medicines and Healthcare Products Regulatory Agency (MHRA) has recommended cross-sectional imaging for all patients with symptomatic MoM bearings. This paper describes the natural history of MoM disease in a 28 mm MoM total hip replacement (THR) using MAR MRI. Inclusion criteria were patients with MoM THRs who had not been revised and had at least two serial MAR MRI scans. All examinations were reported by an experienced observer and classified as A (normal), B (infection) or C1-C3 (mild, moderate, severe MoM-related abnormalities). Between 2002 and 2011 a total of 239 MRIs were performed on 80 patients (two to four scans per THR); 63 initial MRIs (61%) were normal. On subsequent MRIs, six initially normal scans (9.5%) showed progression to a disease state; 15 (15%) of 103 THRs with sequential scans demonstrated worsening disease on subsequent imaging. Most patients with a MoM THR who do not undergo early revision have normal MRI scans. Late progression (from normal to abnormal, or from mild to more severe MoM disease) is not common and takes place over several years.
Clinical Radiology | 2011
A. Mistry; John G. Cahir; Simon T. Donell; John Nolan; Andoni P. Toms
AIMS To define and compare magnetic resonance imaging (MRI) findings of asymptomatic patients with metal-on-metal (MOM) and polyethylene-on-metal (POM) total hip replacements (THRs). MATERIALS AND METHODS Twenty-two THRs in 20 asymptomatic patients (seven men, 13 women, mean age 68 years, range 47-86 years) with normal hip radiographs were included in the study. These comprised 10 POM and 12 MOM bearings. Each patient underwent MRI with metal artefact reduction sequences (MARS) at a mean time of 46 months (POM) and 70 months (MOM) after surgery. Two musculoskeletal radiologists independently read each MRI examination for fluid collections, soft-tissue masses, muscle atrophy, and bone marrow signal changes. RESULTS A pre-MRI hip radiograph showed no significant differences from the postoperative radiograph regarding acetabular inclination, femoral stem angle, and stem mantle grade. There were eight periprosthetic collections (one POM, seven MOM). The majority of THRs had normal gluteal muscles. The ipsilateral piriformis and obturator internus muscles were more frequently abnormal in the MOM group. Overall, there were no significant differences in the number of abnormalities between the two types of bearings. CONCLUSION A range of MRI abnormalities are present in normal asymptomatic THRs but the increased frequency of these associated with MOM THR suggest that some of these changes might represent subclinical disease.
BMC Musculoskeletal Disorders | 2011
Munier Hossain; Daniel J. Parfitt; D J Beard; Clare Darrah; John Nolan; David W. Murray; Glynne Andrew
BackgroundThere are concerns that pre-operative psychological distress might be associated with reduced patient satisfaction after total hip replacement (THR).MethodsWe investigated this in a multi-centre prospective study between January 1999 and January 2002. We dichotomised the patients into the mentally distressed (MHS ≤ 56) and the not mentally distressed (MHS > 56) groups based on their pre-operative Mental Health Score (MHS) of SF36.Results448 patients (340 not distressed and 108 distressed) completed the patient satisfaction survey. Patient satisfaction rate at five year was 96.66% (415/448). There was no difference in patient satisfaction or willingness to have the surgery between the two groups. None of pre-operative variables predicted five year patient satisfaction in logistic regression.ConclusionsPatient satisfaction after surgery may not be adversely affected by pre-operative psychological distress.
American Journal of Roentgenology | 2012
Sarah Yanny; John G. Cahir; Timothy Barker; James Wimhurst; John Nolan; Richard W. Goodwin; Tom Marshall; Andoni P. Toms
OBJECTIVE The aim of this review is to describe the clinical, histopathologic, and MRI features of aseptic lymphocytic vasculitis-associated lesions in total hip replacements. CONCLUSION The introduction of modern metal-on-metal hip arthroplasty has been accompanied by a newly described disease, aseptic lymphocytic vasculitis-associated lesions, which is characterized histologically by bland necrosis and dense perivascular lymphocytic infiltrates. Conventional radiographic findings are often normal, but the typical MRI findings include periprosthetic fluid collections, soft-tissue masses, gluteal tendon avulsion, bone loss, periosteal stripping, neurovascular involvement, and periprosthetic fractures. The severity of the histologic and MRI appearances can be graded according to defined published criteria.
Journal of The Mechanical Behavior of Biomedical Materials | 2014
Michael Bryant; Michael B. Ward; R. Farrar; R. Freeman; K. Brummitt; John Nolan; Anne Neville
This study presents the characterisation of the surface topography, tomography and chemistry of fretting corrosion product found on retrieved polished femoral stems. Scanning Electron Microscopy (SEM), X-ray Photoelectron Spectroscopy (XPS), Transmission Electron Microscopy (TEM) and Fourier Transform Infrared Spectroscopy (FI-IR) were utilised in order to assess the surface morphology of retrieved Metal-on-Metal Total Hip Replacements and surface chemistry of the films found on the surface. Gross slip, plastic deformation and directionality of the surface were extensively seen on the proximal surfaces of the retrievals. A more corrosive phenomenon was observed in the distal regions of the stem, demonstrating a seemingly intergranular attack. Tribochemical reactions were seen to occur within the stem-cement interfaces with tribofilms being observed on the femoral stem and counterpart PMMA bone cement. XPS, TEM-EDX and FT-IR analyses demonstrated that the films present in the stem surfaces were a complex mixture of chromium oxide and amorphous organic material. A comparison between current experimental and clinical literature has been conducted and findings from this study demonstrate that the formation and chemistry of films are drastically influenced by the type of wear or degradation mechanism. Films formed in the stem-cement interface are thought to further influence the biological environment outside the stem-cement interface due to the formation of Cr and O rich films within the interface whilst Co is free to migrate away.
Journal of The Mechanical Behavior of Biomedical Materials | 2014
Michael Bryant; R. Farrar; R. Freeman; K. Brummitt; John Nolan; Anne Neville
The Ultima TPS MoM THR was designed and developed as a 2nd generation MoM THR specifically aimed at younger more active patients due to the anticipated low wear rates and increased longevity of MoM THRs. In 2010, published clinical data highlighted the early failure of the Ultima TPS MoM due to fretting-crevice corrosion at the stem-cement interface. Since 2010 similar observations have been reported by other clinical centres implicating competitor products as well as the Ultima TPS MoM THR. In an attempt to replicate the electrochemical reaction and interactions established across MoM THR systems, fretting-crevice corrosion tests subjected to galvanic coupling were conducted. Galvanic coupling was seen to significantly increase the rates of corrosion under static and dynamic conditions. This was due to the large potential differences developed across the system between active and passive areas, increasing the rates of corrosion and metallic ion release from the stem-cement interface.