John Richard Hadcock

[10] Somatostatin receptor coupling to G proteins

Summary This chapter has focused on the examination of the coupling of G proteins to the somatostatin receptor SSTR1. With the molecular cloning of five distinct subtypes, analysis of each individual receptor is possible. It is now apparent that in many tissues and cells more than one subtype is expressed, making it difficult to assign G proteins and effectors to individual receptor subtypes. Expression of individual receptor subtypes in cell lines that have little or no other somatostatin receptor provides a system for the analysis of specific receptor-G protein coupling that is easier to interpret.