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Dive into the research topics where Joice Soares de Freitas is active.

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Featured researches published by Joice Soares de Freitas.


Advances in Pharmacological Sciences | 2016

The Influence of Palatable Diets in Reward System Activation: A Mini Review

Isabel Cristina de Macedo; Joice Soares de Freitas; Iraci Lucena da Silva Torres

The changes in eating patterns that have occurred in recent decades are an important cause of obesity. Food intake and energy expenditure are controlled by a complex neural system involving the hypothalamic centers and peripheral satiety system (gastrointestinal and pancreatic hormones). Highly palatable and caloric food disrupts appetite regulation; however, palatable foods induce pleasure and reward. The cafeteria diet is such a palatable diet and has been shown consistently to increase body weight and induce hyperplasia in animal obesity models. Moreover, palatable high-fat foods (such as those of the cafeteria diet) can induce addiction-like deficits in brain reward function and are considered to be an important source of motivation that might drive overeating and contribute to the development of obesity. The mechanism of neural adaptation triggered by palatable foods is similar to those that have been reported for nondrug addictions and long-term drug use. Thus, this review attempts to describe the potential mechanisms that might lead to highly palatable diets, such as the cafeteria diet, triggering addiction, or compulsion through the reward system.The changes in eating patterns that have occurred in recent decades are an important cause of obesity. Food intake and energy expenditure are controlled by a complex neural system involving the hypothalamic centers and peripheral satiety system (gastrointestinal and pancreatic hormones). Highly palatable and caloric food disrupts appetite regulation; however, palatable foods induce pleasure and reward. The cafeteria diet is such a palatable diet and has been shown consistently to increase body weight and induce hyperplasia in animal obesity models. Moreover, palatable high-fat foods (such as those of the cafeteria diet) can induce addiction-like deficits in brain reward function and are considered to be an important source of motivation that might drive overeating and contribute to the development of obesity. The mechanism of neural adaptation triggered by palatable foods is similar to those that have been reported for nondrug addictions and long-term drug use. Thus, this review attempts to describe the potential mechanisms that might lead to highly palatable diets, such as the cafeteria diet, triggering addiction, or compulsion through the reward system.


Neurochemical Research | 2017

Increased Oxidative Parameters and Decreased Cytokine Levels in an Animal Model of Attention-Deficit/Hyperactivity Disorder

Douglas Teixeira Leffa; Bruna Bellaver; Carla de Oliveira; Isabel Cristina de Macedo; Joice Soares de Freitas; Eugenio H. Grevet; Wolnei Caumo; Luis Augusto Rohde; André Quincozes-Santos; Iraci Lucena da Silva Torres

Attention-deficit/hyperactivity disorder (ADHD) is a highly heterogeneous disorder characterized by impairing levels of hyperactivity, impulsivity and inattention. Oxidative and inflammatory parameters have been recognized among its multiple predisposing pathways, and clinical studies indicate that ADHD patients have increased oxidative stress. In this study, we aimed to evaluate oxidative (DCFH oxidation, glutathione levels, glutathione peroxidase, catalase and superoxide dismutase activities) and inflammatory (TNF-α, IL-1β and IL-10) parameters in the most widely accepted animal model of ADHD, the spontaneously hypertensive rats (SHR). Prefrontal cortex, cortex (remaining regions), striatum and hippocampus of adult male SHR and Wistar Kyoto rats were studied. SHR presented increased reactive oxygen species (ROS) production in the cortex, striatum and hippocampus. In SHR, glutathione peroxidase activity was decreased in the prefrontal cortex and hippocampus. TNF-α levels were reduced in the prefrontal cortex, cortex (remaining regions), hippocampus and striatum of SHR. Besides, IL-1β and IL-10 levels were decreased in the cortex of the ADHD model. Results indicate that SHR presented an oxidative profile that is characterized by an increase in ROS production without an effective antioxidant counterbalance. In addition, this strain showed a decrease in cytokine levels, mainly TNF-α, indicating a basal deficit. These results may present a new approach to the cognitive disturbances seen in the SHR.


International Journal of Developmental Neuroscience | 2017

Morphine exposure during early life alters thermal and mechanical thresholds in rats

Éllen Almeida Nunes; Liciane Fernandes Medeiros; Joice Soares de Freitas; Isabel Cristina de Macedo; Jonnsin Kuo; Andressa de Souza; Joanna Rippol Rozisky; Wolnei Caumo; Iraci Lucena da Silva Torres

Morphine is an opioid analgesic used to relieve moderate‐to‐severe pain, including pain in neonates at the intensive care unit. In our previous study, we showed that repeated morphine exposure during early life could trigger long‐lasting implications on the developing nervous system, such as long‐term neurochemical and behavioral alterations in adult rats.


Archives of Oral Biology | 2017

Anti-inflammatory effect of an adhesive resin containing indomethacin-loaded nanocapsules

Bruna Genari; Maria Beatriz Cardoso Ferreira; Liciane Fernandes Medeiros; Joice Soares de Freitas; Stefania Giotti Cioato; Iraci Lucena da Silva Torres; Adriana Raffin Pohlmann; Silvia Stanisçuaski Guterres; Vicente Castelo Branco Leitune; Fabrício Mezzomo Collares; Susana Maria Werner Samuel

OBJECTIVE To analyze the anti-inflammatory and analgesic effects of an adhesive resin containing indomethacin-loaded nanocapsules in rat model. DESIGN Adhesive resin disks with or without indomethacin-loaded nanocapsules were subcutaneously implanted into right hind paw of rats. A week after surgical procedure, 2% formalin solution was intradermally injected into plantar surface of paw. Nociceptive and inflammatory responses were evaluated by formalin test. Paw edema by pletismometer and mechanical hyperalgesia by von Frey test were performed on day 2, day 4, day 6, day 8, day 10 and day 12 after surgery. IL-6, IL-10, and lactate dehydrogenase (LDH) serum levels were determined by ELISA-sandwich test. RESULTS Group containing indomethacin-loaded nanocapsules (NC) presented lower edema in the right hind paw at 24h after formalin injection than those of the control group (CT) (P<0.01). NC group showed decrease in the nociceptive response in phase I (neurogenic pain) compared to CT group (NC - 66.86±22.83s X CT - 130.17±35.83s, P<0.001). NC group presented supporting higher intensity of stimulus on days 8 and 12 (24h and 72h after formalin injection) (P<0.01 and P<0.02 respectively). The IL-6 serum level was also significantly higher in the NC group than CT group (p<0.001). CONCLUSIONS These results indicate that an adhesive resin containing indomethacin-loaded nanocapsules has anti-inflammatory and nociceptive activities in a chemical model of acute inflammation. The present investigation confirms an adhesive resin with drug-loaded nanocapsules may be useful for improving therapeutic effect for adhesives to be used in deep cavities.


Inflammation | 2016

Melatonin Alters the Mechanical and Thermal Hyperalgesia Induced by Orofacial Pain Model in Rats

Vanessa Leal Scarabelot; Liciane Fernandes Medeiros; Carla de Oliveira; Lauren Naomi Spezia Adachi; Isabel Cristina de Macedo; Stefania Giotti Cioato; Joice Soares de Freitas; Andressa de Souza; Alexandre Silva Quevedo; Wolnei Caumo; Iraci Lucena da Silva Torres


Archive | 2017

Cafeteria diet increase locomotor activity in wistar male rats

Isabel Cristina de Macedo; Rutiane Ulmann Thoen; Vanessa Giacomeli; Thais Thompsen Silveira; Etiane Micheli Meyer Callai; Joice Soares de Freitas; Éllen Almeida Nunes; Jonnsin Kuo; Martine Elisabeth Kienzle Hagen; Iraci Lucena da Silva Torres


Archive | 2017

Efeito da estimulação transcraniana por corrente contínua (ETCC) sobre parâmetros biométricos de ratos wistar machos submetidos à dieta hipercalórica

João Pedro Abreu da Silva; Joice Soares de Freitas; Isabel Cristina de Macedo; Carla de Oliveira; Vanessa Leal Scarabelot; Wolnei Caumo; Iraci Lucena da Silva Torres


Archive | 2017

Aumento dos parâmetros oxidativos e diminuição dos níveis de citocinas em um modelo de transtorno de déficit de atenção e hiperatividade

Josimar Macedo de Castro; Douglas Teixeira Leffa; Bruna Bellaver; Carla de Oliveira; Isabel Cristina de Macedo; Joice Soares de Freitas; Eugenio H. Grevet; Wolnei Caumo; Luis Augusto Paim Rohde; André Quincozes-Santos; Iraci Lucena da Silva Torres


Archive | 2016

Estimulação transcraniana por corrente contínua melhora a memória de curta duração em um modelo animal do transtorno do déficit de atenção e hiperatividade

Sávio Luiz Santos Lopes; Douglas Teixeira Leffa; Yan Matheus de Brum; Isabel Cristina de Macedo; Bruna Bellaver; Carla de Oliveira; Joice Soares de Freitas; André Quincozes-Santos; Luis Augusto Rohde; Iraci Lucena da Silva Torres


Archive | 2016

Estimulação transcraniana por corrente contínua (tDCS) não altera níveis centrais e periféricos de NGF induzidos pela dor neuropática em ratos

Stefania Giotti Cioato; Liciane Fernandes Medeiros; Paulo Ricardo Marques Filho; Alexandre Silva de Quevedo; Andressa de Souza; Joice Soares de Freitas; Paulo Roberto Stefani Sanches; Wolnei Caumo; Iraci Lucena da Silva Torres

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Iraci Lucena da Silva Torres

Universidade Federal do Rio Grande do Sul

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Isabel Cristina de Macedo

Universidade Federal do Rio Grande do Sul

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Wolnei Caumo

Universidade Federal do Rio Grande do Sul

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Andressa de Souza

Universidade Federal do Rio Grande do Sul

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Carla de Oliveira

Universidade Federal do Rio Grande do Sul

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Liciane Fernandes Medeiros

Universidade Federal do Rio Grande do Sul

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Jonnsin Kuo

Universidade Federal do Rio Grande do Sul

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Éllen Almeida Nunes

Universidade Federal do Rio Grande do Sul

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André Quincozes-Santos

Universidade Federal do Rio Grande do Sul

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Bruna Bellaver

Universidade Federal do Rio Grande do Sul

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