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Jon E. Clark

Schering-Plough

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Publication

Featured researches published by Jon E. Clark.

Tetrahedron Letters | 1996

Preparations of antifungal Sch 42427/SM 9164: Preparative chromatographic resolution, and total asymmetric synthesis via enzymatic preparation of chiral α-hydroxy arylketones

Dinesh Gala; Donald J. DiBenedetto; Jon E. Clark; Bruce L. Murphy; Doris P. Schumacher; Martin Steinman

Abstract Efficient approaches towards the preparation of chiral azole antifungals Sch 42427/SM 9164 (1) via large scale chromatographic separation of its enantiomers, or via enzymatic syntheses of key chiral intermediates α-hydroxy arylketones 5 in excellent enantiomeric excesses (ees) are described.

Journal of Organic Chemistry | 1990

An efficient synthesis of florfenicol

Doris P. Schumacher; Jon E. Clark; Bruce L. Murphy; Peter A. Fischer

Archive | 1988

Pressurized fluorination of hydroxy alkyl groups

Doris P. Schumacher; Jon E. Clark; Bruce L. Murphy

Archive | 1989

Process for preparing oxazoline compounds

Doris P. Schumacher; Jon E. Clark; Bruce L. Murphy

Journal of Organic Chemistry | 1997

An Improved Industrial Synthesis of Florfenicol plus an Enantioselective Total Synthesis of Thiamphenicol and Florfenicol.

Guang-Zhong Wu; Doris P. Schumacher; Wanda Tormos; Jon E. Clark; Bruce L. Murphy

Archive | 1988

Antihistaminic fluoro substituted benzocycloheptapyridines

Doris P. Schumacher; Bruce L. Murphy; Jon E. Clark

Synthesis | 1991

An Enzymatic Route to Florfenicol

Jon E. Clark; Peter Fischer; Doris P. Schumacher

Archive | 1986

Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof

Doris P. Schumacher; Bruce L. Murphy; Jon E. Clark

Journal of Organic Chemistry | 1989

Superacid cyclodehydration of ketones in the production of tricyclic antihistamines

Doris P. Schumacher; Bruce L. Murphy; Jon E. Clark; Pete Tahbaz; Thomas A. Mann

Archive | 1986

Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions

Doris P. Schumacher; Frank J. Villani; Jesse Wong; Bruce L. Murphy; Jon E. Clark

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Doris P. Schumacher

Schering-Plough

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Bruce L. Murphy

Schering-Plough

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Guang-Zhong Wu

Schering-Plough

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Derek Walker

Schering-Plough

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Frank J. Villani

Schering-Plough

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Jesse Wong

Schering-Plough

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Dinesh Gala

Schering-Plough

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Donald J. DiBenedetto

Schering-Plough

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Martin Steinman

Schering-Plough

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Peter A. Fischer

Schering-Plough

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