Jonathan Emeigh
Boehringer Ingelheim
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Publication
Featured researches published by Jonathan Emeigh.
Bioorganic & Medicinal Chemistry Letters | 2009
Jiang-Ping Wu; Roman Wolfgang Fleck; Janice R. Brickwood; Alison Capolino; Katrina Mary Catron; Zhidong Chen; Charles L. Cywin; Jonathan Emeigh; Melissa Foerst; John David Ginn; Matt Hrapchak; Eugene R. Hickey; Ming-Hong Hao; Mohammed A. Kashem; Jun Li; Weimin Liu; Tina Marie Morwick; Richard M. Nelson; Daniel R. Marshall; Leslie Martin; Peter Allen Nemoto; Ian Potocki; Michel Liuzzi; Gregory W. Peet; Erika Scouten; David Stefany; Michael Robert Turner; Steve Weldon; Clare Zimmitti; Denise Spero
An SAR study that identified a series of thienopyridine-based potent IkappaB Kinase beta (IKKbeta) inhibitors is described. With focuses on the structural optimization at C4 and C6 of structure 1 (Fig. 1), the study reveals that small alkyl and certain aromatic groups are preferred at C4, whereas polar groups with proper orientation at C6 efficiently enhance compound potency. The most potent analogues inhibit IKKbeta with IC50s as low as 40 nM, suppress LPS-induced TNF-alpha production in vitro and in vivo, display good kinase selectivity profiles, and are active in a HeLa cell NF-kappaB reporter gene assay, demonstrating that they directly interfere with the NF-kappaB signaling pathway.
Journal of Medicinal Chemistry | 2006
Tina Morwick; Angela Berry; Janice R. Brickwood; Mario G. Cardozo; Katrina Mary Catron; Molly Deturi; Jonathan Emeigh; Carol Ann Homon; Matt Hrapchak; Stephen P. Jacober; Scott Jakes; Paul Kaplita; Terence A. Kelly; John Ksiazek; Michel Liuzzi; Ronald L. Magolda; Can Mao; Daniel R. Marshall; Daniel W. McNeil; Anthony S. Prokopowicz; Christopher Ronald Sarko; Erika Scouten; Cynthia Sledziona; Sanxing Sun; Jane Watrous; Jiang Ping Wu; Charles L. Cywin
Archive | 2003
Charles L. Cywin; Zhidong Chen; Jonathan Emeigh; Roman Wolfgang Fleck; Ming Hong Hao; Eugene R. Hickey; Weimin Will Liu; Daniel R. Marshall; Tina Marie Morwick; Peter Allen Nemoto; Ronald John Sorcek; Sanxing Sun; Jiang-Ping Wu
Archive | 2000
Jiang-Ping Wu; Terence A. Kelly; Rene Marc Lemieux; Daniel R. Goldberg; Jonathan Emeigh; Ronald John Sorcek
Journal of Medicinal Chemistry | 2004
Jiang-Ping Wu; Jonathan Emeigh; Donghong A. Gao; Daniel R. Goldberg; Daniel Kuzmich; Clara K. Miao; Ian Potocki; Kevin Chungeng Qian; Ronald John Sorcek; Deborah D. Jeanfavre; Kei Kishimoto; Elizabeth Mainolfi; Gerald H. Nabozny; Charline Peng; Patricia L. Reilly; Robert Rothlein; Rosemarie Sellati; Joseph R. Woska; Shirlynn Chen; Jocelyn A. Gunn; Drane O'Brien; and Stephen H. Norris; Terence A. Kelly
Organic Letters | 2005
Jiang-Ping Wu; Jonathan Emeigh; Xi-Ping Su
Archive | 2009
Zhidong Chen; Charles L. Cywin; Jonathan Emeigh; Roman Wolfgang Fleck; Ming-Hong Hao; Eugene R. Hickey; Weimin Liu; Daniel Richard Marshall; Tina Morwick; Peter Allen Nemoto; Ronald John Sorcek; Sanxing Sun; Jiang-Ping Wu; ジャン−ピン ウー; ジョナサン エメイ; チャールズ エル サイウィン; サンキシン サン; ロナルド ジョン ソーセック; ジドン チェン; ピーター・エイ・ネモト; ミン−ホン ハオ; ユージーン ヒッキー; ロマン ウォルフガング フレック; ダニエル リチャード マーシャル; ティナ モーウィック; ウェイミン リュー
Archive | 2003
Ch L Cywin; Zhidong Chen; Jonathan Emeigh; Roman Wolfgang Fleck; Ming-Hong Hao; Eugene R. Hickey; Weimin Liu; Daniel R. Marshall; Tina Morwick; Peter Allen Nemoto; Ronald John Sorcek; Sanxing Sun; Jiang-Ping Wu
Archive | 2000
Jiang-Ping Wu; Terence A. Kelly; Rene Marc Lemieux; Daniel R. Goldberg; Jonathan Emeigh; Ronald John Sorcek
Archive | 2000
Jiang-Ping Wu; Terence A. Kelly; Rene Marc Lemieux; Daniel R. Goldberg; Jonathan Emeigh; Ronald John Sorcek
