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Jonathan Emeigh

Boehringer Ingelheim

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Featured researches published by Jonathan Emeigh.

Bioorganic & Medicinal Chemistry Letters | 2009

The discovery of thienopyridine analogues as potent IκB kinase β inhibitors. Part II

Jiang-Ping Wu; Roman Wolfgang Fleck; Janice R. Brickwood; Alison Capolino; Katrina Mary Catron; Zhidong Chen; Charles L. Cywin; Jonathan Emeigh; Melissa Foerst; John David Ginn; Matt Hrapchak; Eugene R. Hickey; Ming-Hong Hao; Mohammed A. Kashem; Jun Li; Weimin Liu; Tina Marie Morwick; Richard M. Nelson; Daniel R. Marshall; Leslie Martin; Peter Allen Nemoto; Ian Potocki; Michel Liuzzi; Gregory W. Peet; Erika Scouten; David Stefany; Michael Robert Turner; Steve Weldon; Clare Zimmitti; Denise Spero

An SAR study that identified a series of thienopyridine-based potent IkappaB Kinase beta (IKKbeta) inhibitors is described. With focuses on the structural optimization at C4 and C6 of structure 1 (Fig. 1), the study reveals that small alkyl and certain aromatic groups are preferred at C4, whereas polar groups with proper orientation at C6 efficiently enhance compound potency. The most potent analogues inhibit IKKbeta with IC50s as low as 40 nM, suppress LPS-induced TNF-alpha production in vitro and in vivo, display good kinase selectivity profiles, and are active in a HeLa cell NF-kappaB reporter gene assay, demonstrating that they directly interfere with the NF-kappaB signaling pathway.

Journal of Medicinal Chemistry | 2006

Evolution of the Thienopyridine Class of Inhibitors of IκB Kinase-β: Part I: Hit-to-Lead Strategies

Tina Morwick; Angela Berry; Janice R. Brickwood; Mario G. Cardozo; Katrina Mary Catron; Molly Deturi; Jonathan Emeigh; Carol Ann Homon; Matt Hrapchak; Stephen P. Jacober; Scott Jakes; Paul Kaplita; Terence A. Kelly; John Ksiazek; Michel Liuzzi; Ronald L. Magolda; Can Mao; Daniel R. Marshall; Daniel W. McNeil; Anthony S. Prokopowicz; Christopher Ronald Sarko; Erika Scouten; Cynthia Sledziona; Sanxing Sun; Jane Watrous; Jiang Ping Wu; Charles L. Cywin

Archive | 2003

Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses

Charles L. Cywin; Zhidong Chen; Jonathan Emeigh; Roman Wolfgang Fleck; Ming Hong Hao; Eugene R. Hickey; Weimin Will Liu; Daniel R. Marshall; Tina Marie Morwick; Peter Allen Nemoto; Ronald John Sorcek; Sanxing Sun; Jiang-Ping Wu

Archive | 2000

Imidazoimidazoles and triazoles as anti-inflammatory agents

Jiang-Ping Wu; Terence A. Kelly; Rene Marc Lemieux; Daniel R. Goldberg; Jonathan Emeigh; Ronald John Sorcek

Journal of Medicinal Chemistry | 2004

Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-α]imidazol-2-one derivatives

Jiang-Ping Wu; Jonathan Emeigh; Donghong A. Gao; Daniel R. Goldberg; Daniel Kuzmich; Clara K. Miao; Ian Potocki; Kevin Chungeng Qian; Ronald John Sorcek; Deborah D. Jeanfavre; Kei Kishimoto; Elizabeth Mainolfi; Gerald H. Nabozny; Charline Peng; Patricia L. Reilly; Robert Rothlein; Rosemarie Sellati; Joseph R. Woska; Shirlynn Chen; Jocelyn A. Gunn; Drane O'Brien; and Stephen H. Norris; Terence A. Kelly

Organic Letters | 2005

Alkylation of magnesium sulfinates: a direct transformation of functionalized aromatic/heteroaromatic halides into sulfones.

Jiang-Ping Wu; Jonathan Emeigh; Xi-Ping Su

Archive | 2009

Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compound, method for producing the same and use thereof

Zhidong Chen; Charles L. Cywin; Jonathan Emeigh; Roman Wolfgang Fleck; Ming-Hong Hao; Eugene R. Hickey; Weimin Liu; Daniel Richard Marshall; Tina Morwick; Peter Allen Nemoto; Ronald John Sorcek; Sanxing Sun; Jiang-Ping Wu; ジャン−ピン ウー; ジョナサン エメイ; チャールズ エル サイウィン; サンキシン サン; ロナルド ジョン ソーセック; ジドン チェン; ピーター・エイ・ネモト; ミン−ホン ハオ; ユージーン ヒッキー; ロマン ウォルフガング フレック; ダニエル リチャード マーシャル; ティナ モーウィック; ウェイミン リュー

Archive | 2003

SUBSTITUIERTE 3-AMINO-THIENO(2,3-b)PYRIDINE-2-AMIDE UND HERSTELLUNGSVERFAHREN SOWIE DEREN VERWENDUNG SUBSTITUTED 3-AMINO-THIENO (2,3-b) PYRIDINES-2-AMIDES AND PRODUCTION METHOD AND USE THEREOF

Ch L Cywin; Zhidong Chen; Jonathan Emeigh; Roman Wolfgang Fleck; Ming-Hong Hao; Eugene R. Hickey; Weimin Liu; Daniel R. Marshall; Tina Morwick; Peter Allen Nemoto; Ronald John Sorcek; Sanxing Sun; Jiang-Ping Wu

Archive | 2000

Imidazoimidazole and triazoles as anti-inflammatory agents

Jiang-Ping Wu; Terence A. Kelly; Rene Marc Lemieux; Daniel R. Goldberg; Jonathan Emeigh; Ronald John Sorcek

Archive | 2000

Imidazoimidazole und -triazole als entzündungshemmende mittel Imidazoimidazole -triazoles and as antiinflammatory agents

Jiang-Ping Wu; Terence A. Kelly; Rene Marc Lemieux; Daniel R. Goldberg; Jonathan Emeigh; Ronald John Sorcek

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Jiang-Ping Wu

Boehringer Ingelheim

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Ronald John Sorcek

Boehringer Ingelheim

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Terence A. Kelly

Boehringer Ingelheim

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Daniel R. Goldberg

Boehringer Ingelheim

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Charles L. Cywin

Boehringer Ingelheim

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Daniel R. Marshall

Boehringer Ingelheim

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Eugene R. Hickey

Boehringer Ingelheim

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Peter Allen Nemoto

Boehringer Ingelheim

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Rene Marc Lemieux

Boehringer Ingelheim

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Roman Wolfgang Fleck

Boehringer Ingelheim

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