Jonathan G. Martin | Researchain

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Featured researches published by Jonathan G. Martin.

Bioorganic & Medicinal Chemistry Letters | 1992

Structure-activity relationships of the pyridazinone series of 5-lipoxygenase inhibitors

Dee W. Brooks; Anwer Basha; Francis A. J. Kerdesky; James H. Holms; James D. Ratajcyk; Pramila Bhatia; Jimmie L. Moore; Jonathan G. Martin; Steven P. Schmidt; Daniel H. Albert; Richard D. Dyer; Patrick R. Young; George W. Carter

Abstract Structure activity analysis of the pyridazinone series as represented by the initial lead compound A-53612 revealed that the 1-phenyl-2H-tetrahydropyridazin-3-one structure was necessary for inhibitory activity as several modifications diverging from this structure led to a dramatic loss of inhibitory activity. Substituents on the phenyl ring had a marked effect on inhibitory activity and methemoglobinemia toxicity.

Archive | 1990

Urea based lipoxygenase inhibiting compounds

Dee W. Brooks; Daniel J. Kerkman; Jonathan G. Martin; Andrew O. Stewart; James B. Summers

Journal of Medicinal Chemistry | 1988

Orally active hydroxamic acid inhibitors of leukotriene biosynthesis

James B. Summers; Bruce P. Gunn; Jonathan G. Martin; Hormoz Mazdiyasni; Andrew O. Stewart; Patrick R. Young; Andrew M. Goetze; Jennifer B. Bouska; Richard D. Dyer

Journal of Medicinal Chemistry | 1988

Structure-activity analysis of a class of orally active hydroxamic acid inhibitors of leukotriene biosynthesis

James B. Summers; Bruce P. Gunn; Jonathan G. Martin; Michael B. Martin; Hormoz Mazdiyasni; Andrew O. Stewart; Patrick R. Young; Jennifer B. Bouska; Andrew M. Goetze; Richard D. Dyer

Journal of Medicinal Chemistry | 1997

Structure−Activity Relationships of N-Hydroxyurea 5-Lipoxygenase Inhibitors

Andrew O. Stewart; Pramila Bhatia; Jonathan G. Martin; James B. Summers; Karen E. Rodriques; Michael B. Martin; James H. Holms; Jimmie L. Moore; Richard A. Craig; Teodozyj Kolasa; James D. Ratajczyk; Hormoz Mazdiyasni; Francis A. J. Kerdesky; Shari L. DeNinno; Robert G. Maki; Jennifer B. Bouska; Patrick R. Young; Carmine Lanni; Randy L. Bell; George W. Carter; Clint D. W. Brooks

Journal of Medicinal Chemistry | 1995

(R)-(+)-N-[3-[5-[4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor

Clint D. W. Brooks; Andrew O. Stewart; Anwer Basha; Pramila Bhatia; James D. Ratajczyk; Jonathan G. Martin; Richard A. Craig; Teodozyj Kolasa; Jennifer B. Bouska; Carmine Lanni

Journal of Medicinal Chemistry | 1995

Preparation of (R)-(+)-N-[3-[5-[(4-Fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor.

Clint D. W. Brooks; Andrew O. Stewart; Anwer Basha; Pramila Bhatia; James D. Ratajczyk; Jonathan G. Martin; Richard A. Craig; Teodozyj Kolasa; Jennifer B. Bouska; Carmine Lanni; Richard R. Harris; Peter E. Malo; George W. Carter; Randy L. Bell

Archive | 1991