Jonathan Seckl
Baylor College of Medicine
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Publication
Featured researches published by Jonathan Seckl.
Journal of Biological Chemistry | 2000
Louise J. S. Williams; Val Lyons; Iolaina MacLeod; Vidya Rajan; Gretchen J. Darlington; Valeria Poli; Jonathan Seckl; Karen Chapman
Glucocorticoid action within individual cells is potently modulated by 11β-hydroxysteroid dehydrogenase (11β-HSD), which, by interconverting active and inert glucocorticoids, determines steroid access to receptors. Type 1 11β-HSD (11β-HSD1) is highly expressed in liver where it regenerates glucocorticoids, thus amplifying their action and contributing to induction of glucocorticoid-responsive genes, most of which are also regulated by members of the C/EBP (CAAT/enhancer-binding protein) family of transcription factors. Here we demonstrate that C/EBPα is a potent activator of the 11β-HSD1 gene in hepatoma cells and that mice deficient in C/EBPα have reduced hepatic 11β-HSD1expression. In contrast, C/EBPβ is a relatively weak activator of 11β-HSD1 transcription in hepatoma cells and attenuates C/EBPα induction, and mice that lack C/EBPβ have increased hepatic 11β-HSD1 mRNA. The 11β-HSD1promoter (between −812 and +76) contains 10 C/EBP binding sites, and mutation of the promoter proximal sites decreases the C/EBP inducibility of the promoter. One site encompasses the transcription start, and both C/EBPα and C/EBPβ are present in complexes formed by liver nuclear proteins at this site. The regulation of 11β-HSD1 expression, and hence intracellular glucocorticoid levels, by members of the C/EBP family provides a novel mechanism for cross-talk between the C/EBP family of transcription factors and the glucocorticoid signaling pathway.
Archive | 2003
Brian R. Walker; Jonathan Seckl; John Savill; Jamie Gilmour; Karen Chapman
Archive | 2000
Louise J. S. Williams; Val Lyons; Iolaina MacLeod; Vidya Rajan; Gretchen J. Darlington; Valeria Polii; Jonathan Seckl; Karen Chapman
Society for Endocrinology BES 2016 | 2016
Manu Verma; Tiina Kipari; Tak Yung Man; Thorsten Forster; Natalie Homer; Jonathan Seckl; Megan C. Holmes; Karen Chapman
WOS | 2013
Katri Raikkonen; Anu-Katriina Pesonen; James R. O'Reilly; Eero Kajantie; Pia M. Villa; Hannele Laivuori; Esa Hämäläinen; Jonathan Seckl; Rebecca Reynolds
Society for Endocrinology BES 2013 | 2013
Kajal Manwani; Tak Yung Man; Christopher J. Kenyon; Ruth Andrew; Karen Chapman; Jonathan Seckl
Society for Endocrinology BES 2013 | 2013
Zhenguang Zhang; Agnes E. Coutinho; Patrick Hadoke; Donald Salter; Jonathan Seckl; Karen Chapman
Society for Endocrinology BES 2013 | 2013
Simon C. Riley; Hilary O. D. Critchley; Jonathan Seckl; Rebecca Reynolds
Archive | 2013
Cristina L. Esteves; Val Kelly; Valérie Bégay; Simon G. Lillico; Achim Leutz; Jonathan Seckl; Karen Chapman
Society for Endocrinology BES 2012 | 2012
Amanda J Drake; Rebecca L. Jones; Hilary O. D. Critchley; Simon C. Riley; Jonathan Seckl; Rebecca Reynolds