Jong-Sik Kim

Antifungal Activity of Phenanthrene Derivatives from Aerial Bulbils of Dioscorea batatas Decne

Plants of the genus Dioscorea have long been used as oriental folk medicine, and Dioscorea batatas Decne has been cultivated for healthy food in Korea. Although the bulbils were produced 2,000 ton annually, there are few reports for bioactive compounds in bulbils. In this study, three phenanthrenes and two phenanthraquinones were isolated from the aerial bulbils of D. batatas Decne, and their structures were elucidated. Among them, compound 2 (6-hydroxy-2,7-dimethoxy-1,4-phenanthraquinone) has not been reported previously. Evaluation of antimicrobial activities based on disk-diffusion assay, MIC and MFC showed the compound 12 (6,7-dihydroxy-2,4-dimethoxyphenanthrene) has strong antimicrobial activity with 25 ㎍/㎖ of MIC and MFC against Candida albicans. Our results suggested that compound 12 has a potent antifungal activity, and the antimicrobial activity and its spectrum are modulated by hydroxylation and methoxylation of phenanthrene ring moiety of the compound.

Evaluation of In-vitro Anticoagulation Activity of 33 Different Medicinal Herbs

한방 생약재로부터 안전하면서도 신규의 항혈전제를 개발하기 위해, 현재 국내에서 유통되고 있는 국내 및 국외산 한방 생약재 33종을 대상으로 40종의 에탄올 추출물을 조제하고, 이들의 thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (aPTT)을 평가하였다. 생약재중 중국산은 28종으로 대부분이 국외산이었으며, 부위별로는 종자 및 뿌리 부위가 19종을 차지하였다. 평균 수분함량은

Anti-Proliferative Activities of Solid-State Fermented Medicinal Herbs Using Phellinus baumii against Human Colorectal HCT116 Cell

6.85{\pm}2.26%

Toxicity Evaluation of Endocrine Disrupting Chemicals Using Human HepG2 Cell Line, Lumbricus rubellus and Saccharomyces cerevisiae

, 평균 추출율은

Antifungal Activity of Zanthoxylium schinifolium Against Fusarium graminearum, a Barley Powdery Mildew Fungus.

5.27{\pm}4.25%

Microbial biodegradation and toxicity of vinclozolin and its toxic metabolite 3,5-dichloroaniline.

를 나타내었다. 조제된 시료의 TT평가 결과, 사인(중국), 고본, 팔각향, 계지, 당삼, 계혈등, 행인, 오배자, 괄루근 및 포황에서 우수한 트롬빈 저해활성을 확인하였으며, 다양한 농도에서 평가 결과 계혈등, 행인, 팔각향, 계지, 오배자 추출물 순으로 트롬빈 저해능이 강력함을 확인하였다. PT 평가 결과 오배자, 계혈등, 행인에서, aPTT 평가결과 오배자 및 계혈등에서 우수한 항혈전능을 확인하였다. 한편 추출물의 인간적혈구 용혈활성을 평가한 결과, 계혈등, 팔각향, 계지, 오배자 추출물은

Evaluation of Antimicrobial, Antithrombin, and Antioxidant Activity of Dioscorea batatas Decne

500\;{\mu}g/ml

Solid Fermentation of Medicinal Herb Using Phellinus baumii Mycelium and Anti-thrombin and Anti-oxidation Activity of its Methanol Extract

농도에서도 용혈활성이 없음을 확인하여 이들 4종을 최종 선정하였다. 본 연구결과는 이미 대량생산이 확립된 한방생약제로부터 우수한 항혈전제 개발이 가능함을 제시하고 있으며, 트롬빈 및 혈장 응고 인자에 대한 특이 저해제 개발이 가능함을 제시하고 있다. 【This study was carried out to develop safe and novel anticoagulation agents from oriental medicinal herbs. From 33 medicinal herbs, 40 different ethanol extracts were prepared according to place of origin or extraction parts, and anticoagulation activities were evaluated by determination of thrombin time (TT), prothrombin time (PT) and activated partial thromboplastin time (aPTT). The average water content and average extraction ratio for the medicinal herbs were

Antimicrobial Activity of Fruit of Crataegus pinnatifida Bunge against Multidrug Resistant Pathogenic Pseudomonas aeruginosa and Candida sp.

6.85{\pm}2.26%

Comparison of in vivo nephrotoxicity in the rabbit by a pyrrolidinyl-thio Carbapenem CW-270031.

and