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Dive into the research topics where Joong-Shin Park is active.

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Featured researches published by Joong-Shin Park.


Psychological Medicine | 2016

Altered serotonin transporter binding potential in patients with obsessive-compulsive disorder under escitalopram treatment: [11C]DASB PET study.

Eun-Kyu Kim; Oliver Howes; Joong-Shin Park; Sung Nyun Kim; Sang-Goo Shin; Bo-Hyung Kim; Federico Turkheimer; Yun-Sang Lee; Jung-Taek Kwon

BACKGROUND Obsessive-compulsive disorder (OCD) is a chronic, relapsing mental illness. Selective serotonin reuptake inhibitors block serotonin transporters (SERTs) and are the mainstay of treatment for OCD. SERT abnormalities are reported in drug-free patients with OCD, but it is not known what happens to SERT levels during treatment. This is important as alterations in SERT levels in patients under treatment could underlie poor response, or relapse during or after treatment. The aim of the present study was first to validate a novel approach to measuring SERT levels in people taking treatment and then to investigate SERT binding potential (BP) using [11C]DASB PET in patients with OCD currently treated with escitalopram in comparison with healthy controls. METHOD Twelve patients and age- and sex-matched healthy controls were enrolled. The patients and healthy controls underwent serial PET scans after administration of escitalopram and blood samples for drug concentrations were collected simultaneously with the scans. Drug-free BPs were obtained by using an inhibitory E max model we developed previously. RESULTS The inhibitory E max model was able to accurately predict drug-free SERT BP in people taking drug treatment. The drug-free BP in patients with OCD currently treated with escitalopram was significantly different from those in healthy volunteers [Cohens d = 0.03 (caudate), 1.16 (putamen), 1.46 (thalamus), -5.67 (dorsal raphe nucleus)]. CONCLUSIONS This result extends previous findings showing SERT abnormalities in drug-free patients with OCD by indicating that altered SERT availability is seen in OCD despite treatment. This could account for poor response and the high risk of relapse in OCD.


British Journal of Surgery | 2017

Randomized clinical trial of immersive virtual reality tour of the operating theatre in children before anaesthesia

Junhee Ryu; Sung-Moo Park; Joong-Shin Park; Jin Won Kim; Hee Jeong Yoo; Tae-You Kim; Joon-Seok Hong; Sung-Sik Han

A virtual reality (VR) tour of the operating theatre before anaesthesia could provide a realistic experience for children. This study was designed to determine whether a preoperative VR tour could reduce preoperative anxiety in children.


Psychological Medicine | 2016

Disruption of effective connectivity from the dorsolateral prefrontal cortex to the orbitofrontal cortex by negative emotional distraction in obsessive–compulsive disorder

Hyun Jung Han; W. H. Jung; J.-Y. Yun; Joong-Shin Park; Kang Ik K. Cho; Ji-Won Hur; N. Y. Shin; Tae Young Lee; Jun Soo Kwon

BACKGROUND Obsessive-compulsive disorder (OCD) has been associated with abnormal cognitive and emotional functions and these dysfunctions may be dependent on the disruption of dynamic interactions within neuronal circuits associated with emotion regulation. Although several studies have shown the aberrant cognitive-affective processing in OCD patients, little is known about how to characterize effective connectivity of the disrupted neural interactions. In the present study, we applied effective connectivity analysis using dynamic causal modeling to explore the disturbed neural interactions in OCD patients. METHOD A total of 20 patients and 21 matched healthy controls performed a delayed-response working memory task under emotional or non-emotional distraction while undergoing functional magnetic resonance imaging. RESULTS During the delay interval under negative emotional distraction, both groups showed similar patterns of activations in the amygdala. However, under negative emotional distraction, the dorsolateral prefrontal cortex (DLPFC) and the orbitofrontal cortex (OFC) exhibited significant differences between groups. Bayesian model averaging indicated that the connection from the DLPFC to the OFC was negatively modulated by negative emotional distraction in patients, when compared with healthy controls (p < 0.05, Bonferroni-corrected). CONCLUSIONS Exaggerated recruitment of the DLPFC may induce the reduction of top-down prefrontal control input over the OFC, leading to abnormal cortico-cortical interaction. This disrupted cortico-cortical interaction under negative emotional distraction may be responsible for dysfunctions of cognitive and emotional processing in OCD patients and may be a component of the pathophysiology associated with OCD.


Obstetrics & gynecology science | 2003

Molecular Biological Approach to Find Out the Etiology of Hypertensive Disorder in Pregnancy: Analysis of the Polymorphism in the Promoter of Human Angiotensinogen Gene in Korean Population

Soon-Sup Shim; Jae-Yoon Shim; June-Hee Lim; Joong-Shin Park; J. K. Jun; Kwang-Bum Bai; Bo-Hyun Yoon; Syn Hee-Chul


Obstetrics & gynecology science | 2009

Spontaneous uterine rupture during second trimester

Jae-Won Kim; Tae Hoon Kim; Sunmin Kim; Jung-Min Yoon; Hyung-Su Lim; Chan-Wook Park; Joong-Shin Park; Jong-Kwan Jeon; Hee-Chul Syn


Obstetrics & gynecology science | 2006

Delayed-Interval Delivery after Cerclage Operation in a Case of Twin Pregnancy with One Fetal Delivery

Hyunjung Lee; J. K. Jun; Mee-Kyung Kim; Won-Jeong Yoo; Soon-Sup Shim; Joong-Shin Park; Bo-Hyun Yoon; Hee-Chul Syn


Obstetrics & gynecology science | 2006

Perinatal Outcomes of Triplet Pregnancies

Soo-Jin Chae; Won-Jeong Yoo; Kue-Hyun Kang; Byoung-Jae Kim; Si-Eun Lee; Yoo-Kyung Sohn; Soon-Sup Shim; Joong-Shin Park; J. K. Jun; Bo-Hyun Yoon; Hee-Chul Syn


Obstetrics & gynecology science | 2005

A case of myocardial infarction during pregnancy

Seung-Su Han; Chang-Weon Jung; Yong-Jin Kim; Jayeon Kim; Soon-Sup Shim; Joong-Shin Park; J. K. Jun; Bo-Hyun Yoon; Hee-Chul Syn


Obstetrics & gynecology science | 2002

Nonimmune hydrops fetalis: clinical characteristics and prognostic factors of neonatal survival

Joong-Yeup Lee; Yoo-Kyung Sohn; Soon-Sup Shim; June-Hee Im; Jae-Yoon Shim; Joong-Shin Park; J. K. Jun; Bo-Hyun Yoon; Hee-Chul Syn


Obstetrics & gynecology science | 2002

A Case of Postpartum Ovarian Vein Thrombosis After Vaginal Delivery

Joon-Seok Hong; Yoo-Kyung Sohn; Kunwoo Kim; Yong-Tark Jeon; Joong-Shin Park; J. K. Jun; Bo-Hyun Yoon; Hee-Chul Syn

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J. K. Jun

Seoul National University

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Bo-Hyun Yoon

Seoul National University

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Soon-Sup Shim

Seoul National University

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Chan-Wook Park

Seoul National University

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Yoo-Kyung Sohn

Seoul National University

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Soo-Yeon Han

Seoul National University Hospital

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Hyewon Jeon

Seoul National University

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Joon-Seok Hong

National Institutes of Health

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