Jörg Frei
Novartis
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Publication
Featured researches published by Jörg Frei.
Cancer Chemotherapy and Pharmacology | 1993
Helmut Mett; Jaroslav Stanek; Juan A. Lopez-Ballester; Juhani Jänne; Leena Alhonen; Riita Sinervirta; Jörg Frei; Urs Regenass
Analogues of 3-aminooxy-1-propanamine proved to be highly potent and selective inhibitors of ornithine decarboxylase (ODC). The compounds competed with ornithine for the substrate binding site of ODC, but resulted in progressive and apparently irreversible inactivation of the enzyme. Diamine oxidase was inhibited by these compounds to a lesser extent than ODC; the compounds were not metabolized by this enzyme. Several derivatives were growth-inhibitory for human T24 cells and for other mammalian cells, the most active compound being 3-aminooxy-2-fluoro-1-propanamine (AFPA). Growth-arrested cells were largely depleted of putrescine and spermidine. Cellular growth arrest could be antagonized by supplementation with spermidine. Selection for resistance against AFPA led to cells with amplified ODC genes and overexpression of the message. Some of the derivatives were tumoristatic at well-tolerated doses in mice bearing solid T24 tumours. The antiproliferative activity of these compounds appears to be mediated by polyamine depletion.
Archive | 1996
Peter Traxler; Guido Bold; Wolfgang Karl-Diether Brill; Jörg Frei
Archive | 1998
Guido Bold; Jörg Frei; Peter Traxler; Karl-Heinz Altmann; Helmut Mett; David Stover; Jeanette Marjorie Wood
Journal of Medicinal Chemistry | 2000
Guido Bold; Karl-Heinz Altmann; Jörg Frei; Marc Lang; Paul W. Manley; Peter Traxler; Bernhard Wietfeld; Josef Brüggen; Elisabeth Buchdunger; Robert Cozens; Stefano Ferrari; Pascal Furet; Francesco Hofmann; Georg Martiny-Baron; Johannes Rösel; Matthew A. Sills; David Stover; Figan Acemoglu; Eugen Boss; René Emmenegger; Laurent Lässer; Elvira Masso; Rosemarie Roth; Christian Schlachter; Werner Vetterli; Dominique Wyss; Jeanette Marjorie Wood
Archive | 1997
Guido Bold; Jörg Frei; Marc Lang; Peter Traxler; Pascal Furet
Archive | 1996
Peter Traxler; Pascal Furet; Guido Bold; Jörg Frei; Marc Lang
Archive | 1997
Peter Traxler; Jörg Frei; Guido Bold
Archive | 1997
Peter Traxler; Guido Bold; Marc Lang; Jörg Frei
Journal of Medicinal Chemistry | 1993
Jaroslav Stanek; Giorgio Caravatti; Jörg Frei; Pascal Furet; Helmut Mett; Peter Schneider; Urs Regenass
Archive | 1977
Jörg Frei; Knut A. Jaeggi; Franz Ostermayer; Herbert Schroter