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Joseph Barbosa

Bristol-Myers Squibb

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Publication

Featured researches published by Joseph Barbosa.

Bioorganic & Medicinal Chemistry Letters | 2009

Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation.

Junqing Guo; Andrew Watson; James Kempson; Marianne Carlsen; Joseph Barbosa; Karen Stebbins; Deborah Lee; John H. Dodd; Steven G. Nadler; Murray McKinnon; Joel C. Barrish; William J. Pitts

A series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells are presented. These compounds were found to have effects on T cell proliferation, however it is not clear whether the mechanism is related to PDE7 inhibition.

Archive | 2002

Pyrimidine inhibitors of phosphodiesterase (PDE) 7

Junqing Guo; Joseph Barbosa; William J. Pitts; Marianne Carlsen; Claude A. Quesnelle; Marco Dodier

Archive | 2002

Fused heterocyclic inhibitors of phosphodiesterase (pde) 7

William J. Pitts; Joseph Barbosa; Junqing Guo

Archive | 2002

Quinazoline and pyrido[2,3-d]pyrimidine inhibitors of phosphodiesterase (PDE) 7

William J. Pitts; Joseph Barbosa

Archive | 2002

Purine inhibitors of phosphodiesterase (pde) 7

Wayne Vaccaro; Jacques Y. Roberge; Katerina Leftheris; William J. Pitts; Joseph Barbosa

Archive | 2003

Fused heterocyclic compounds and use thereof

Joseph Barbosa; William J. Pitts; Junqing Guo

Bioorganic & Medicinal Chemistry Letters | 2005

Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13)

Soong-Hoon Kim; Andrew T. Pudzianowski; Kenneth J. Leavitt; Joseph Barbosa; Patricia A. McDonnell; William J. Metzler; Bruce M. Rankin; Richard Liu; Wayne Vaccaro; William J. Pitts

Bioorganic & Medicinal Chemistry Letters | 2004

Identification of purine inhibitors of phosphodiesterase 7 (PDE7).

William J. Pitts; Wayne Vaccaro; Tram Huynh; Katerina Leftheris; Jacques Y. Roberge; Joseph Barbosa; Junqing Guo; Baerbel R. Brown; Andrew Watson; Karen L. Donaldson; Gary C. Starling; Peter A. Kiener; Michael A. Poss; John H. Dodd; Joel C. Barrish

Bioorganic & Medicinal Chemistry Letters | 2005

Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure–activity relationships

James Kempson; William J. Pitts; Joseph Barbosa; Junqing Guo; Omonike Omotoso; Andrew Watson; Karen Stebbins; Gary C. Starling; John H. Dodd; Joel C. Barrish; Raymond Felix; Karl Fischer

Archive | 2002

Barbituric acid derivatives as inhibitors of TNF-alpha converting enzyme (TACE) and/or matrix metalloproteinases

Jingwu Duan; Bin Jiang; Lihua Chen; Zhonghui Lu; Joseph Barbosa; William J. Pitts

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William J. Pitts

Bristol-Myers Squibb

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Junqing Guo

Bristol-Myers Squibb

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Wayne Vaccaro

Bristol-Myers Squibb

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Jacques Y. Roberge

Bristol-Myers Squibb

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Katerina Leftheris

Bristol-Myers Squibb

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Marianne Carlsen

Bristol-Myers Squibb

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Andrew Watson

Bristol-Myers Squibb

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Claude A. Quesnelle

Bristol-Myers Squibb

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Joel C. Barrish

Bristol-Myers Squibb

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John H. Dodd

Bristol-Myers Squibb

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