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Dive into the research topics where Joseph F. Krebs is active.

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Featured researches published by Joseph F. Krebs.


Biochemistry | 1998

Interaction of the Baculovirus Anti-apoptotic Protein p35 with Caspases. Specificity, Kinetics, and Characterization of the Caspase/p35 Complex†

Qiao Zhou; Joseph F. Krebs; Scott J. Snipas; Annamarie Price; Emad S. Alnemri; Kevin J. Tomaselli; Guy S. Salvesen


Biochemistry | 1991

Functional consequences of engineering the hydrophobic pocket of carbonic anhydrase II

Carol A. Fierke; Tiffany L. Calderone; Joseph F. Krebs


Journal of Medicinal Chemistry | 2005

First-in-Class Pan Caspase Inhibitor Developed for the Treatment of Liver Disease

Steven D. Linton; Teresa Aja; Robert A. Armstrong; Xu Bai; Long-Shiuh Chen; Ning Chen; Brett Weylan Ching; Patricia C. Contreras; Jose-Luis Diaz; Craig D. Fisher; Lawrence C. Fritz; Patricia L. Gladstone; Todd Groessl; Xin Gu; Julia Herrmann; Brad P. Hirakawa; Niel C. Hoglen; Kathy G. Jahangiri; Vincent J. Kalish; Donald S. Karanewsky; Lalitha Kodandapani; Joseph F. Krebs; Jeff McQuiston; Steven P. Meduna; Kip Nalley; Edward D. Robinson; Robert O. Sayers; Kristen Sebring; Alfred P. Spada; Robert J. Ternansky


Journal of Cell Biology | 1999

Activation of Membrane-associated Procaspase-3 Is Regulated by Bcl-2

Joseph F. Krebs; Robert C. Armstrong; Anu Srinivasan; Teresa Aja; Angela M. Wong; Aileen Aboy; Rob Sayers; Bryan Pham; Tam Vu; Kim Hoang; Donald S. Karanewsky; Christian Leist; Albert Schmitz; Joe C. Wu; Kevin J. Tomaselli; Lawrence C. Fritz


Biochemistry | 1993

Kinetic and spectroscopic studies of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II.

Joseph F. Krebs; Fazale R. Rana; Richard A. Dluhy; Carol A. Fierke


Journal of Biological Chemistry | 1993

Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II.

Joseph F. Krebs; Joseph A. Ippolito; David W. Christianson; Carol A. Fierke


Journal of Biological Chemistry | 1993

Determinants of catalytic activity and stability of carbonic anhydrase II as revealed by random mutagenesis.

Joseph F. Krebs; Carol A. Fierke


Biochemistry | 1991

Conformational Mobility of His-64 in the Thr-200 → Ser Mutant of Human Carbonic Anhydrase II

Joseph F. Krebs; Carol A. Fierke; Richard S. Alexander; David W. Christianson


Biochemistry | 1993

Engineering a cysteine ligand into the zinc binding site of human carbonic anhydrase II

Laura L. Kiefer; Joseph F. Krebs; Steven A. Paterno; Carol A. Fierke


Biochemistry | 1995

Structural basis of inhibitor affinity to variants of human carbonic anhydrase II.

Satish K. Nair; Joseph F. Krebs; David W. Christianson; Carol A. Fierke

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Emad S. Alnemri

Thomas Jefferson University

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