Joseph G. Mayo
University of Illinois at Chicago
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Publication
Featured researches published by Joseph G. Mayo.
Cancer Letters | 2002
Qiuwen Mi; Baoliang Cui; Gloria L. Silva; Daniel D. Lantvit; Eula Lim; Heebyung Chai; Melinda G. Hollingshead; Joseph G. Mayo; A. Douglas Kinghorn; John M. Pezzuto
P-Glycoprotein (Pgp)-mediated drug efflux can yield a multidrug-resistance phenotype that is associated with poor response to cancer chemotherapy. Pervilleines B and C (PB and PC), two new tropane alkaloid aromatic esters obtained from a chloroform extract of the roots of Erythroxylum pervillei as the result of bioactivity-guided fractionation, were found to restore the vinblastine (VLB) sensitivity of cultured multidrug-resistant KB-V1 cells, with 50% inhibitory concentration values of 0.17 microM in each case. To explore the potential relevance of this response, KB-V1 cells were placed in hollow fibers and implanted into NCr nu/nu mice. Cell growth was not significantly inhibited when VLB or PB or PC were administered as single agents, but when used in combination with vinblastine inhibition of up to 77.7% was observed. Equimolar doses of verapamil were less effective. These data suggest that PB and PC are effective inhibitors of Pgp and should be further evaluated for clinical utility.
Cancer Research | 1988
Michael C. Alley; Dominic A. Scudiero; Anne Monks; Miriam L. Hursey; Maciej Czerwinski; Donald L. Fine; B. J. Abbott; Joseph G. Mayo; Robert H. Shoemaker; Michael R. Boyd
Journal of the National Cancer Institute | 1991
Anne Monks; Dominic A. Scudiero; Philip Skehan; Robert H. Shoemaker; Kenneth D. Paull; David Vistica; Curtis Hose; John Langley; Paul Cronise; Anne Vaigro-Wolff; Marcia Gray-Goodrich; Hugh D. Campbell; Joseph G. Mayo; Michael R. Boyd
Life Sciences | 1995
Melinda G. Hollingshead; Michael C. Alley; Richard F. Camalier; B. J. Abbott; Joseph G. Mayo; Louis Malspeis; Michael R. Grever
Cancer Research | 1975
Thomas H. Corbett; Daniel P. Griswold; Joseph G. Mayo; W. R. Laster; Frank M. Schabel
Journal of Natural Products | 2002
Qiuwen Mi; Daniel D. Lantvit; Eulenia Reyes-Lim; Heebyung Chai; Weimin Zhao; Ik-Soo Lee; Sergio R. Peraza-Sánchez; Olipa Ngassapa; Leonardus B S Kardono; O Soedarsono Riswan; Melinda G. Hollingshead; Joseph G. Mayo; Norman R. Farnsworth; Geoffrey A. Cordell; Ad Kinghorn; John M. Pezzuto
Cancer Research | 2001
Qiuwen Mi; Baoliang Cui; Gloria L. Silva; Daniel D. Lantvit; Eula Lim; Heebyung Chai; Min You; Melinda G. Hollingshead; Joseph G. Mayo; A. Douglas Kinghorn; John M. Pezzuto
Cancer Research | 1969
William Leach; W. Russell Laster; Joseph G. Mayo; Daniel P. Griswold; Frank M. Schabel
Cancer Research | 1987
Elieser Gorelik; Artemio A. Ovejera; Robert H. Shoemaker; Allan P. Jarvis; Michael C. Alley; Ronald Duff; Joseph G. Mayo; Ronald B. Herberman; Michael R. Boyd
Journal of the National Cancer Institute | 1990
James B. McMahon; Steven M. Schmid; Owen S. Weislow; Sherman F. Stinson; Richard F. Camalier; Robert J. Gulakowski; Robert H. Shoemaker; Rebecca Kiser; Donald J. Dykes; Steadman D. Harrison; Joseph G. Mayo; Michael R. Boyd
Collaboration
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