Joseph H. Burckhalter

Fluorescein isothiocyanates: Improved synthesis and purity: Spectral studies

Abstract Modification of the methods of synthesis by direct reaction of the isomeric aminofluoresceins with a limited excess of thiophosgene in the presence of calcium carbonate has yielded the 5- and 6-isothiocyanatofluoresceins of high purity. The ir and nmr spectra of these isomers are described.

Inhibition of hepatic lipid biosynthesis by 1-(3-chlorophenyl)-1-methyl-2-phenyl-2-(2-pyridine) ethanol, a hypocholesterolemic agent.

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