Joseph L. Sanguinetti

The Ground Side of an Object Perceived as Shapeless yet Processed for Semantics

Traditional theories of perception posit that only objects access semantics; abutting, patently shapeless grounds do not. Surprisingly, this assumption has been untested until now. In two experiments, participants classified silhouettes as depicting meaningful real-world or meaningless novel objects while event-related potentials (ERPs) were recorded. The borders of half of the novel objects suggested portions of meaningful objects on the ground side. Participants were unaware of these meaningful objects because grounds are perceived as shapeless. In Experiment 1, in which silhouettes were presented twice, N400 ERP repetition effects indicated that semantics were accessed for novel silhouettes that suggested meaningful objects in the ground and for silhouettes that depicted real-world objects, but not for novel silhouettes that did not suggest meaningful objects in the ground. In Experiment 2, repetition was manipulated via matching prime words. This experiment replicated the effect observed in Experiment 1. These experiments provide the first neurophysiological evidence that semantic access can occur for the apparently shapeless ground side of a border.

The subthalamic nucleus contributes to post-error slowing

pFC is proposed to implement cognitive control via directed “top–down” influence over behavior. But how is this feat achieved? The virtue of such a descriptive model is contingent on a mechanistic understanding of how motor execution is altered in specific circumstances. In this report, we provide evidence that the well-known phenomenon of slowed RTs following mistakes (post-error slowing) is directly influenced by the degree of subthalamic nucleus (STN) activity. The STN is proposed to act as a brake on motor execution following conflict or errors, buying time so a more cautious response can be made on the next trial. STN local field potentials from nine Parkinson disease patients undergoing deep brain stimulation surgery were recorded while they performed a response conflict task. In a 2.5- to 5-Hz frequency range previously associated with conflict and error processing, the degree phase consistency preceding the response was associated with increasingly slower RTs specifically following errors. These findings provide compelling evidence that post-error slowing is in part mediated by a corticosubthalamic “hyperdirect” pathway for increased response caution.

Semantic access occurs outside of awareness for the ground side of a figure

Traditional theories of vision assume that figures and grounds are assigned early in processing, with semantics being accessed later and only by figures, not by grounds. We tested this assumption by showing observers novel silhouettes with borders that suggested familiar objects on their ground side. The ground appeared shapeless near the figure’s borders; the familiar objects suggested there were not consciously perceived. Participants’ task was to categorize words shown immediately after the silhouettes as naming natural versus artificial objects. The words named objects from the same or from a different superordinate category as the familiar objects suggested in the silhouette ground. In Experiment 1, participants categorized words faster when they followed silhouettes suggesting upright familiar objects from the same rather than a different category on their ground sides, whereas no category differences were observed for inverted silhouettes. This is the first study to show unequivocally that, contrary to traditional assumptions, semantics are accessed for objects that might be perceived on the side of a border that will ultimately be perceived as a shapeless ground. Moreover, although the competition for figural status results in suppression of the shape of the losing contender, its semantics are not suppressed. In Experiment 2, we used longer silhouette-to-word stimulus onset asynchronies to test whether semantics would be suppressed later in time, as might occur if semantics were accessed later than shape memories. No evidence of semantic suppression was observed; indeed, semantic activation of the objects suggested on the ground side of a border appeared to be short-lived. Implications for feedforward versus dynamical interactive theories of object perception are discussed.

Topographic deficits in alpha-range resting EEG activity and steady state visual evoked responses in schizophrenia

Deficits in both resting alpha-range (8-12Hz) electroencephalogram (EEG) activity and steady state evoked potential (SSVEP) responses have been reported in schizophrenia. However, the topographic specificity of these effects, the relationship between resting EEG and SSVEP, as well as the impact of antipsychotic medication on these effects, have not been clearly delineated. The present study sought to address these questions with 256 channel high-density EEG recordings in a group of 13 schizophrenia patients, 13 healthy controls, and 10 non-schizophrenia patients with psychiatric diagnoses currently taking antipsychotic medication. At rest, the schizophrenia group demonstrated decreased alpha EEG power in frontal and occipital areas relative to healthy controls. With SSVEP stimulation centered in the alpha band (10Hz), but not with stimulation above (15Hz) or below (7Hz) this range, the occipital deficit in alpha power was partially reverted. However, the frontal deficit persisted and contributed to a significantly reduced topographic relationship between occipital and frontal alpha activity for resting EEG and 10Hz SSVEP alpha power in schizophrenia patients. No significant differences were observed between healthy and medicated controls or between medicated controls and schizophrenia. These findings suggest a potential intrinsic deficit in frontal eyes-closed EEG alpha oscillations in schizophrenia, whereby potent visual stimulation centered in that frequency range results in an increase in the occipital alpha power of these patients, which however does not extend to frontal regions. Future research to evaluate the cortical and subcortical mechanisms of these effects is warranted.

A behavioral task sets an upper bound on the time required to access object memories before object segregation

Traditional theories of vision assume that object segregation occurs before access to object memories. Yet, behavioral evidence shows that familiar configuration is a prior for segregation, and electrophysiological experiments demonstrate these memories are accessed rapidly. A behavioral index of the speed of access is lacking, however. Here we asked how quickly behavior is influenced by object memories that are accessed in the course of object segregation. We investigated whether access to object memories on the groundside of a border can slow behavior during a rapid categorization task. Participants viewed two silhouettes that depicted a real-world and a novel object. Their task was to saccade toward the real-world object as quickly as possible. Half of the nontarget novel objects were ambiguous in that a portion of a real-world object was suggested, but not consciously perceived, on the groundside of their borders. The rest of the nontargets were unambiguous. We tested whether saccadic reaction times were perturbed by the real-world objects suggested on the groundside of ambiguous novel silhouettes. In Experiments 1 and 2, saccadic reaction times were slowed when nontargets were ambiguous rather than unambiguous. Experiment 2 set an upper limit of 190 ms on the time required for object memories in grounds to influence behavior. Experiment 3 ruled out factors that could have produced longer latencies other than access to object memories. These results provide the first behavioral index of how quickly memories of objects suggested in grounds can influence behavior, placing the upper limit at 190 ms.

Non-invasive neural stimulation

Neurotechnologies for non-invasively interfacing with neural circuits have been evolving from those capable of sensing neural activity to those capable of restoring and enhancing human brain function. Generally referred to as non-invasive neural stimulation (NINS) methods, these neuromodulation approaches rely on electrical, magnetic, photonic, and acoustic or ultrasonic energy to influence nervous system activity, brain function, and behavior. Evidence that has been surmounting for decades shows that advanced neural engineering of NINS technologies will indeed transform the way humans treat diseases, interact with information, communicate, and learn. The physics underlying the ability of various NINS methods to modulate nervous system activity can be quite different from one another depending on the energy modality used as we briefly discuss. For members of commercial and defense industry sectors that have not traditionally engaged in neuroscience research and development, the science, engineering and technology required to advance NINS methods beyond the state-of-the-art presents tremendous opportunities. Within the past few years alone there have been large increases in global investments made by federal agencies, foundations, private investors and multinational corporations to develop advanced applications of NINS technologies. Driven by these efforts NINS methods and devices have recently been introduced to mass markets via the consumer electronics industry. Further, NINS continues to be explored in a growing number of defense applications focused on enhancing human dimensions. The present paper provides a brief introduction to the field of non-invasive neural stimulation by highlighting some of the more common methods in use or under current development today.

Accessing meaning for the groundside of a figure: How long does it last?

• Consistent with view that potential objects on opposite sides of borders are processed to high levels in a first pass of processing • Figure-ground perception entails inhibitory competition between possible objects on opposite sides of a border • Previous study[1]: Are the semantics of the competing objects accessed before figure assignment? • Strategy: Assess whether semantics of loser are accessed • Task: categorize words as naming natural/artificial objects • Words followed silhouettes with real-world, familiar shapes suggested but not perceived on the groundside • 83 ms silhouette-to-word SOA