Jothy Kandasamy

The role of endoscopic third ventriculostomy in adult patients with hydrocephalus.

OBJECT Endoscopic third ventriculostomy (ETV) is the treatment of choice for hydrocephalus, but the outcome is dependent on the cause of this disorder, and the procedure remains principally the preserve of pediatric neurosurgeons. The role of ETV in adult patients with hydrocephalus was therefore investigated. METHODS One hundred ninety adult patients underwent ETV for hydrocephalus. Cases were defined as primary ETV (newly diagnosed, without a previously placed shunt) and secondary ETV (performed for shunt malfunctions due to infection or mechanical blockage). Causes of hydrocephalus included tumor, long-standing overt ventriculomegaly (LOVA), Chiari malformation Types I and II (CM-I and -II), aqueduct stenosis, spina bifida, and intraventricular hemorrhage (IVH). Successful ETV was defined as resolution of symptoms with shunt independence. Operative complications and ETV failure rate were investigated according to the causes of hydrocephalus and between the primary and secondary ETV groups. RESULTS In the primary group, ETV was successful in 107 (83%) of 129 patients, including those with tumors (52 of 66), LOVA (21 of 24), CM-I (11 of 11 cases), CM-II (8 of 9), aqueduct stenosis (8 of 9), and IVH (2 of 2). In the secondary group, ETV was successful in 41 (67%) of 61 patients and was equally successful in cases of mechanical shunt malfunction (35 of 52 patients) and infected shunt malfunction (6 of 9 patients). The median time to ETV failure was 1.7 months in the primary group and 0.5 months in the secondary group. The majority of ETV failures occurred within the first 3 months, and thereafter, the Kaplan-Meier survival curves plateaued. There were no procedure-related deaths, and complications were seen in only 5.8% of cases. CONCLUSIONS The success rate of ETVs in adults is comparable, if not better, than in children. In addition to the well-defined role of ETV in the treatment of hydrocephalus caused by tumors and aqueduct stenosis, ETV may also have a role in the management of CM-I, LOVA, persistent shunt infection, and IVH resistant to other CSF diversion procedures.

Effect of electromagnetic-navigated shunt placement on failure rates: a prospective multicenter study.

OBJECT As many as 40% of shunts fail in the first year, mainly due to proximal obstruction. The role of catheter position on failure rates has not been clearly demonstrated. The authors conducted a prospective cohort study of navigated shunt placement compared with standard blind shunt placement at 3 European centers to assess the effect on shunt failure rates. METHODS All adult and pediatric patients undergoing de novo ventriculoperitoneal shunt placement were included (patients with slit ventricles were excluded). The first cohort underwent standard shunt placement using anatomical landmarks. All centers subsequently adopted electromagnetic (EM) navigation for routine shunt placements, forming the second cohort. Catheter position was graded on postoperative CT in both groups using a 3-point scale developed for this study: (1) optimal position free-floating in CSF; (2) touching choroid or ventricular wall; or (3) intraparenchymal. Episodes and type of shunt revision were recorded. Early shunt failure was defined as that occurring within 30 days of surgery. Patients with shunts were followed-up for 12 months in the standard group, for a median of 6 months in the EM-navigated group, or until shunt failure. RESULTS A total of 75 patients were included in the study, 41 with standard shunts and 34 with EM-navigated shunts. Seventy-four percent of navigated shunts were Grade 1 compared with 37% of the standard shunts (p=0.001, chi-square test). There were no Grade 3 placements in the navigated group, but 8 in the standard group, and 75% of these failed. Early shunt failure occurred in 9 patients in the standard group and in 2 in the navigated group, reducing the early revision rate from 22 to 5.9% (p=0.048, Fisher exact test). Early shunt failures were due to proximal obstruction in 78% of standard shunts (7 of 9) and in 50% of EM-navigated shunts (1 of 2). CONCLUSIONS Noninvasive EM image guidance in shunt surgery reduces poor shunt placement, resulting in a significant decrease in the early shunt revision rate.

The impact of antibiotic-impregnated catheters on shunt infection in children and neonates

IntroductionInfection remains a significant problem with cerebrospinal fluid (CSF) diversion procedures. Antibiotic-impregnated shunt catheters (AIS) have been introduced to prevent infection, mainly in the early post-operative period when most infections occur. We evaluate the impact on infection rates in children following the introduction of catheters impregnated with rifampicin and clindamycin.Materials and methodsThe study was a retrospective analysis of all paediatric shunt procedures undertaken after the introduction of AIS systems in 2003. All procedures where a complete AIS system was implanted were included. For the purpose of analysis, shunt procedures were classified as de novo (group 1), clean revision (group 2) and following external ventricular drainage with either sterile CSF (group 3) or infected CSF (group 4). Results were compared to a historical cohort of shunt procedures undertaken before the introduction of AIS catheters.ResultsA total of 214 AIS were implanted in 150 children between October 2003 and December 2006. There were 4 infections in group 1 (8.5%), 6 infections in group 2 (5.3%) and 11 infections in groups 3 and 4 (20%). The historical control group comprised 77 shunts in 65 children. The infection rate in neonatal de novo shunts reduced from 27 to 10.4% following the introduction of AIS catheters.ConclusionsAIS catheters can reduce the number of shunt infections seen in clinical practice in certain subgroups. This has had a significant impact on the neonatal hydrocephalic population. The high risk of shunt infection after a period of external ventricular drainage raises the issue of emergence of bacterial resistance.

Raised intracranial pressure and hydrocephalus following hindbrain decompression for Chiari I malformation: a case series and review of the literature‡

Object. Chiari-syringomyelia is a heterogeneous condition that may be treated by decompression of the foramen magnum. Raised intracranial pressure (ICP) and/or hydrocephalus is a rare complication of this treatment. We aim to describe the incidence, clinical presentation, radiographic findings, management and outcome of patients developing raised ICP and/or hydrocephalus after hindbrain decompression for Chiari I malformation. Methods. Retrospective analysis of 138 consecutive adult and paediatric patients with Chiari I malformation who underwent foramen magnum decompression. Results. The incidence of post-operative symptomatic raised ICP and/or hydrocephalus in this series was 8.7%. Overall, 9 of 12 patients developing raised ICP or hydrocephalus required a VP shunt, an overall incidence of 6.5%. However, 3 of 12 patients were successfully managed with external ventricular drainage or conservatively. Presentation was with headache or CSF wound leak at a median of 13 days post-operatively. Subdural hygromata were observed in five cases in association with hydrocephalus and urgent drainage to relieve mass effect was required in two cases. At a mean follow up of 36 months, 9 of 12 patients were asymptomatic. Conclusions. There is a risk of requiring a permanent VP shunt associated with decompression for Chiari I even in the absence of ventriculomegaly or signs of raised ICP pre-operatively. Patients presenting with new symptoms or CSF wound leak following FMD mandate investigation to exclude hydrocephalus, raised ICP or subdural hygroma.

Subdural empyema secondary to sinus infection in children

ObjectiveTo evaluate the impact, on morbidity and mortality, of aggressive surgical management of subdural empyema of sinus origin in children.MethodThe authors conducted a retrospective review of 20 children admitted between 2000–2007 to Alder Hay Children Hospital and The Walton centre for Neurology and Neurosurgery for subdural empyema secondary to sinus infection. Clinical presentation, duration of symptoms, radiological investigations, surgical treatment and post-operative outcome were evaluated.ResultsOutcome was favourable in 19 cases. In four cases, there were re-accumulation requiring surgical evacuation, four patients experienced post-operative seizures but were seizure-free at follow-up. There was only one mortality in the series.ConclusionSubdural empyema secondary to sinus infection, although uncommon, it could be associated with a relative high morbidity and mortality rate. Early aggressive surgical and medical management with drainage of intracranial or sinus collections and antibiotics therapy lead to a low mortality or morbidity rate and good clinical outcome.

Chiari I malformation without hydrocephalus: acute intracranial hypertension managed with endoscopic third ventriculostomy (ETV)

IntroductionIn a small subset of patients, a Chiari malformation can present with signs of raised intracranial pressure due to obstruction of cerebrospinal fluid flow or with the raised intracranial pressure as the primary pathological driving force resulting in tonsillar herniation.Case reportThe authors report a unique case in a 14-year-old boy with a Chiari malformation type 1–syringomyelia complex with slit-like ventricles. We have successfully managed the acute presentation of raised intracranial pressure, mimicking idiopathic intracranial hypertension, utilizing a frameless stereotactic image-navigated endoscopic third ventriculostomy alone. We present the preoperative and postoperative radiological and ophthalmological findings and discuss the possible mechanisms related to the pathophysiology and treatment in this case. The patient’s symptoms resolved immediately postoperatively with resolution of papilledema. At 18-month follow-up, the patient remains entirely asymptomatic and the need for craniovertebral decompression appears to have been obviated.ConclusionWe advocate that in the Chiari malformation type 1–syringomyelia complex with normal or small ventricles, patients presenting with isolated signs and symptoms of raised intracranial pressure alone can be safely and effectively managed with an electromagnetic-guided stereotactic endoscopic third ventriculostomy as a primary treatment option.

Third ventriculostomy in normal pressure hydrocephalus.

Endoscopic third ventriculostomy (ETV) has become established as the treatment of choice in cases of uncomplicated occlusive hydrocephalus, but the clinical indications are continually being challenged. The role of ETV in so-called communicating hydrocephalus is often discussed within the context of the ongoing debate on cerebrospinal fluid flow pathways and the disruption caused by varying pathological entities. The increasing number of published reports outlining the efficacy of ETV in noncommunicating or obstructive hydrocephalus, with comparatively low complication rates, has led to attempts by some in the neurosurgical community to redefine its role in patients with communicating hydrocephalus and in particular normal pressure hydrocephalus. A randomized matched cohort with similar inclusion/exclusion criteria and objective and independent multidisciplinary assessments of preoperative assessment and postoperative outcome would be required to define the role of ETV in this group of patients.

Treatment of scaphocephaly with combined vertex craniectomy and bilateral microbarrel staving.

Introduction and Background:Surgical techniques for the treatment of scaphocephaly continue to evolve; however, there is still no accepted criterion standard. Until recently, the Alder Hey supraregional craniofacial departments experience was principally with combined wide-vertex suturectomy and biparietal barrel stave osteotomies. Aims and Objectives:To determine whether the technique of wide-vertex suturectomy and biparietal barrel stave osteotomies improves the cephalic index (CI) in scaphocephalic patients and determine whether age at surgery influences outcomes. Patients and Methods:A literature review was undertaken to confirm recognized outcome measures. Patients who had surgery between 2000 and 2006 were enrolled in the audit. Prospective database review allowed preoperative and postoperative data collection at 6 weeks, 6 months, and 2 years. Statistical analysis was performed with Statview V.5.0.1 (Adept Scientific, Letchworth, UK). Results:Of 73 children referred to the unit with scaphocephaly, 66 underwent surgery. Of these 66 children, 54 were boys and 12 girls. Mean age at surgery was 11.1 months, with a mode of 6 months and a median of 8 months (range, 4-56 mo). Mean change in CI from the preoperative value was significant at 6 weeks (P < 0.0001) and 6 months (P < 0.0001) after surgery. Early correction of scaphocephaly (≤9 mo) was associated with a normal CI at 6 weeks after surgery (P = 0.03). Conclusions:Wide-vertex suturectomy with biparietal barrel stave osteotomies are effective at increasing the CI in children with scaphocephaly. Early correction is associated with an improved CI in the short term, but long-term outcomes are unclear and require further follow-up studies.

External ventricular drainage: Is it time to look at national practice?

Aimun A. B. Jamjoom 1 , Angelos G. Kolias 2 , Malik Zaben 3 , Aswin Chari 2 , John Kitchen 4 , Alexis Joannides 2 , Paul M. Brennan 1 , Jothy Kandasamy 1 , Silvia Gatscher 5 , William P. Gray 3 , Michael D. Jenkinson 4 , Diederik O. Bulters 6 , Conor L. Mallucci 7 , Helmut Schuster 8 , Peter J. Hutchinson 2 & Aminul I. Ahmed 6 ; UK Neurosurgical Research Network & British Neurosurgical Trainee Research Collaborative

Central sleep apnea and associated Chiari malformation in children with syndromic craniosynostosis: treatment and outcome data from a supraregional national craniofacial center

OBJECT The association of Chiari malformation Type I (CM-I) with syndromic craniosynostosis (SC) in children is well established. Central sleep apnea (CSA) may subsequently occur. However, sleep studies performed in these patients have been focused mainly on assessing the severity of obstructive sleep apnea. Therefore, the incidence and management of CSA in these patients remains poorly defined. Authors of this study aimed to assess the efficacy of foramen magnum decompression (FMD) in resolving CSA, initially detected incidentally, in a small cohort of patients with CM-I and SC. METHODS The clinical data for 5 children who underwent FMD for CSA at Alder Hey Childrens Hospital between December 2007 and December 2009 were retrospectively analyzed. Outcomes were evaluated with respect to FMDs by utilizing pre- and postdecompression sleep studies. Of the 5 patients, 2 had Crouzon syndrome and 3 had Pfeiffer syndrome. RESULTS Patient age at the time of surgery ranged from 1.1 to 12.6 years (median 4.1 years). The median postoperative follow-up was 3.6 years. Sleep studies revealed that 2 children experienced a > 80% reduction in CSAs at 1.5 and 21 months after decompression. The remaining 3 children experienced a > 60% reduction in CSAs when reevaluated between 2 and 10 months after decompression. The associated central apnea index improved for all patients. CONCLUSIONS Findings suggested that FMD is an effective treatment modality for improving CSA in patients with SC and associated CM-I. The use of multimodal polysomnography technology may improve the evaluation and management of these patients.