Jozsef Szejtli

Sulfated Cyclodextrin Derivatives

Large number of sulfated derivatives of cyclodextrin (CD) monomers have been described in the literature [1], for preparation of water soluble CD polymer sulfates, however, only two references can be found [2,3]. Sulfated derivatives can be prepared by reacting the CD with chlorosulfonic acid or SO3 complexes. The average degree of substitution (DS) of the product can be calculated based on sulfur content or from the results of MS, NMR, IR or titrimetric measurements.

Separation of Phenylalanine and Tyrosine from Protein Hydrolysates

Phenylalanine-free protein hydrolysates are needed for dietetic treatment of phenylketonuria. However, the phenylalanine-free protein hydrolysates commercially available deliver an unpalatable off-flavour. This is caused possibly by the sulfuric acid hydrolysis of proteins followed by calcium hydroxid neutralisation (1). This type of hydrolysis is necessary to get products without salt, Although several publications (2) e, g. discuss the purification of protein hydrolysates from off-flavour, the sensory quality of such products is yet insufficient and must be improved. Otherwise the patients show an aversion to the high daily intake of such products within the diet.