Juan Dupont

Translocation (2;3) in hematologic malignancies

Cytogenetic studies have revealed nonrandom involvement of some chromosomes in specific structural abnormalities in human neoplasias. In this report we present three patients with t(2;3) associated with hematologic malignancies, and review the pertinent literature. These findings lead us to regard the region between 3q26 and 3q29 as implicated in chromosomal changes in these disorders, whereas, no vulnerable point has been observed in chromosome #2. We suggest that these translocations may activate genes on chromosome #3 related to these neoplasias.

Abnormalities of chromosome No. 1: Two cases with lymphocytic lymphomas

Abstract Two cases of lymphocytic lymphoma with a duplication of part of the long arm of chromosome #1, between bands 1q25 and 1q32, are presented. The coincidence between this finding with others in the literature supports the concept that this specific chromosome segment is related to the proliferative advantage of malignant cells in neoplasia.

Ph1-negative chronic myelocytic leukemia (CML) with an unusual karyotype☆

Abstract A case of Ph 1 -negative chronic myelocytic leukemia is reported. Cytogenetic analysis and the development of colonies in soft agar culture 2 months before the clinical manifestation of the acute phase of the disease clearly indicated the bad prognosis of the patient. An extra #8 chromosome was found in 23% of his cells. Also of note was the presence of an abnormal clone characterized by t(12;13).