Judit Lienert

Environmental toxicology and risk assessment of pharmaceuticals from hospital wastewater.

In this paper, we evaluated the ecotoxicological potential of the 100 pharmaceuticals expected to occur in highest quantities in the wastewater of a general hospital and a psychiatric center in Switzerland. We related the toxicity data to predicted concentrations in different wastewater streams to assess the overall risk potential for different scenarios, including conventional biological pretreatment in the hospital and urine source separation. The concentrations in wastewater were estimated with pharmaceutical usage information provided by the hospitals and literature data on human excretion into feces and urine. Environmental concentrations in the effluents of the exposure scenarios were predicted by estimating dilution in sewers and with literature data on elimination during wastewater treatment. Effect assessment was performed using quantitative structure-activity relationships because experimental ecotoxicity data were only available for less than 20% of the 100 pharmaceuticals with expected highest loads. As many pharmaceuticals are acids or bases, a correction for the speciation was implemented in the toxicity prediction model. The lists of Top-100 pharmaceuticals were distinctly different between the two hospital types with only 37 pharmaceuticals overlapping in both datasets. 31 Pharmaceuticals in the general hospital and 42 pharmaceuticals in the psychiatric center had a risk quotient above 0.01 and thus contributed to the mixture risk quotient. However, together they constituted only 14% (hospital) and 30% (psychiatry) of the load of pharmaceuticals. Hence, medical consumption data alone are insufficient predictors of environmental risk. The risk quotients were dominated by amiodarone, ritonavir, clotrimazole, and diclofenac. Only diclofenac is well researched in ecotoxicology, while amiodarone, ritonavir, and clotrimazole have no or very limited experimental fate or toxicity data available. The presented computational analysis thus helps setting priorities for further testing. Separate treatment of hospital wastewater would reduce the pharmaceutical load of wastewater treatment plants, and the risk from the newly identified priority pharmaceuticals. However, because high-risk pharmaceuticals are excreted mainly with feces, urine source separation is not a viable option for reducing the risk potential from hospital wastewater, while a sorption step could be beneficial.

Stakeholder analysis combined with social network analysis provides fine-grained insights into water infrastructure planning processes

Environmental policy and decision-making are characterized by complex interactions between different actors and sectors. As a rule, a stakeholder analysis is performed to understand those involved, but it has been criticized for lacking quality and consistency. This lack is remedied here by a formal social network analysis that investigates collaborative and multi-level governance settings in a rigorous way. We examine the added value of combining both elements. Our case study examines infrastructure planning in the Swiss water sector. Water supply and wastewater infrastructures are planned far into the future, usually on the basis of projections of past boundary conditions. They affect many actors, including the population, and are expensive. In view of increasing future dynamics and climate change, a more participatory and long-term planning approach is required. Our specific aims are to investigate fragmentation in water infrastructure planning, to understand how actors from different decision levels and sectors are represented, and which interests they follow. We conducted 27 semi-structured interviews with local stakeholders, but also cantonal and national actors. The network analysis confirmed our hypothesis of strong fragmentation: we found little collaboration between the water supply and wastewater sector (confirming horizontal fragmentation), and few ties between local, cantonal, and national actors (confirming vertical fragmentation). Infrastructure planning is clearly dominated by engineers and local authorities. Little importance is placed on longer-term strategic objectives and integrated catchment planning, but this was perceived as more important in a second analysis going beyond typical questions of stakeholder analysis. We conclude that linking a stakeholder analysis, comprising rarely asked questions, with a rigorous social network analysis is very fruitful and generates complementary results. This combination gave us deeper insight into the socio-political-engineering world of water infrastructure planning that is of vital importance to our well-being.

High acceptance of urine source separation in seven European countries: a review.

Urine source separation (NoMix-technology) is a promising innovation aiming at a resource-oriented, decentralized approach in urban water management. However, NoMix-technology has a sensitive end-point: peoples bathrooms. NoMix-technology is increasingly applied in European pilot projects, but the success from a user point-of-view has rarely been systematically monitored. We aim at closing this gap. We review surveys on acceptance, including reuse of human urine as fertilizer, from 38 NoMix-projects in 7 Northern and Central European countries with 2700 respondents. Additionally, we identify explanatory variables with logistic regression of a representative Swiss library survey. NoMix-technology is well accepted; around 80% of users liked the idea, 75-85% were satisfied with design, hygiene, smell, and seating comfort of NoMix-toilets, 85% regarded urine-fertilizers as good idea (50% of farmers), and 70% would purchase such food. However, 60% of users encountered problems; NoMix-toilets need further development. We found few differences among countries, but systematic differences between public and private settings, where people seem more critical. Information was positively correlated with acceptance, and, e.g., a good mood or environmentally friendly behavior. For future success of NoMix-projects, we recommend authorities follow an integral strategy. Lay people will then find the NoMix-concept appealing and support this promising bathroom innovation.

Isozyme variability of the wetland specialist Swertia perennis (Gentianaceae) in relation to habitat size, isolation, and plant fitness

We examined the effects of size and spatial isolation of fens on the isozyme variability of 17 populations of Swertia perennis. This long-lived perennial is a locally abundant fen specialist in Switzerland, where wetlands have been strongly fragmented. Isozyme variability was comparable to other outcrossing plants (A = 1.53, AP(p) = 2.01, P(p) = 42.5, H(o) = 0.113, H(e) = 0.139). F statistics indicated both inbreeding within and differentiation between populations (F(IS) = 0.076, F(IT) = 0.194, F(ST) = 0.128), with moderate gene flow between populations (N(e)m = 1.703). Populations in small, isolated fens had reduced genetic variability and the highest within-population inbreeding coefficients (F(IS)). Isozyme variability was significantly associated with vegetative fitness traits (MANOVA), and the magnitude of leaf herbivory decreased as the percentage of polymorphic loci increased. These data suggest that the reduced genetic variability of S. perennis in small, isolated populations may reduce plant fitness, thereby increasing susceptibility to herbivore damage. Our study also shows that habitat fragmentation can reduce the genetic variability of populations of fairly common habitat specialists, which so far have attracted less conservation attention than rare species.

Source separation and decentralization for wastewater management.

Is sewer-based wastewater treatment really the optimal technical solution in urban water management? This paradigm is increasingly being questioned. Growing water scarcity and the insight that water will be an important limiting factor for the quality of urban life are main drivers for new approaches in wastewater management. Source Separation and Decentralization for Wastewater Management sets up a comprehensive view of the resources involved in urban water management. It explores the potential of source separation and decentralization to provide viable alternatives to sewer-based urban water management. During the 1990s, several research groups started working on source-separating technologies for wastewater treatment. Source separation was not new, but had only been propagated as a cheap and environmentally friendly technology for the poor. The novelty was the discussion whether source separation could be a sustainable alternative to existing end-of-pipe systems, even in urban areas and industrialized countries. Since then, sustainable resource management and many different source-separating technologies have been investigated. The theoretical framework and also possible technologies have now developed to a more mature state. At the same time, many interesting technologies to process combined or concentrated wastewaters have evolved, which are equally suited for the treatment of source-separated domestic wastewater. The book presents a comprehensive view of the state of the art of source separation and decentralization. It discusses the technical possibilities and practical experience with source separation in different countries around the world. The area is in rapid development, but many of the fundamental insights presented in this book will stay valid. Source Separation and Decentralization for Wastewater Management is intended for all professionals and researchers interested in wastewater management, whether or not they are familiar with source separation. ISBN: 9781780401072 (eBook) ISBN: 9781843393481 (Print)

Local extinctions of the wetland specialist Swertia perennis L. (Gentianaceae) in Switzerland: a revisitation study based on herbarium records

Abstract We studied population extinction of the locally abundant fen plant Swertia perennis in Switzerland and used up to 127-year old herbarium records to relocate 63 sites that had once hosted this species. We recorded current site characteristics and related them to the absence or abundance of populations. Fifty-four sites (86%) were still traditionally used (extensively mown or grazed). Fifteen populations (24%) had gone extinct. Extinction was more likely at lower altitude, in the peripheral distribution range of S. perennis (58% peripheral, 9% central populations extinct), on the smallest fens (75% extinct on fens 2 ) and on fens with intensified land use. However, even on traditionally managed wetlands 18.5% of the populations had gone extinct. Moreover, 40% of all remaining populations were smaller than 250 flowering plants. We conclude that both intensified agricultural practice and habitat fragmentation contributed to local extinction of S. perennis . Small populations, especially, may not be able to persist in the long term.

Methodological aspects of multi-criteria decision analysis for policy support: A case study on pharmaceutical removal from hospital wastewater

Decision making in public and political contexts can be complex. Multi-attribute value/utility theory (MAVT/MAUT) can support such decision processes by providing a transparent framework that helps focusing on objectives and corresponding degrees of achievement by different alternatives.

Effects of habitat fragmentation on population structure and fitness components of the wetland specialist Swertia perennis L. (Gentianaceae)

Summary We assessed the effects of habitat fragmentation on the demography of the locally abundant, long-lived fen plant Swertia perennis L., by examining population structure, components of fitness and herbivory of 17 populations in Switzerland. We distinguished between large MAIN, small, barely isolated NEAR and small, geographically isolated DISTANT habitat islands. Large isolation distance of small sites significantly affected the transition from sub-adult to adult age states: the mean population density was reduced by 30%, the density of vegetative adults by 60% and the density of reproductive adults by 78% on DISTANT compared with NEAR islands. Seedling survivorship decreased significantly from MAIN to NEAR to DISTANT islands. Moreover, several vegetative components of fitness were significantly reduced on DISTANT islands, i.e. the length and number of leaves and the stem height. Finally, leaf herbivory was highest on small NEAR islands. Our results indicate that population viability of S. perennis is reduced on small, isolated fens, possibly because of arrested individual adult growth due to inbreeding. In contrast, environmental influences such as higher productivity through increased nutrient influx on small sites may be responsible for changed plant-herbivore interactions. Wir untersuchten die Auswirkungen von Habitatfragmentierung auf die Demographie des Moorenzians ( Swertia perennis L.), eines langlebigen Flachmoor-Spezialisten. Dazu verglichen wir Populationsstruktur, Fitnes-Merkmale und Herbivorie von 17 Populationen im Schweizerischen Alpenvorland. Wir unterschieden zwischen grosen ‘MAIN’, kleinen, kaum isolierten ‘NEAR’ und kleinen, geographisch isolierten ‘DISTANT’ Habitatinseln. Der Ubergang von sub-adulten zu adulten Individuen wurde durch die raumliche Isolation signifikant verringert: Auf DISTANT-, verglichen mit NEAR-Inseln, war die mittlere Populationsdichte um 30%, die Dichte von vegetativen Adulten um 60% und die Dichte von reproduktiven Adulten um 78% reduziert. Das Uberleben von Keimlingen nahm von MAIN- uber NEAR- zu DISTANT-Inseln signifikant ab. Mehrere vegetative Wachstumsmerkmale waren auf DISTANT-Inseln ebenfalls signifikant verringert, so die Lange und Anzahl von Blattern und die Stengelhohe. Ferner war die Herbivorie von Blattern auf den kleinen NEAR-Inseln am hochsten. Diese Resultate zeigen, das die Vitalitat von S. perennis in kleinen, isolierten Flachmooren herabgesetzt ist, was moglicherweise auf Inzucht zuruckzufuhren ist. Dagegen konnten Umwelteinflusse, wie erhohte Standortsfertilitat durch Nahrstoffeintrag, auf kleinen Flachen fur veranderte Interaktionen von Herbivoren mit Pflanzen verantwortlich sein.

Tackling uncertainty in multi-criteria decision analysis – An application to water supply infrastructure planning

We present a novel approach for practically tackling uncertainty in preference elicitation and predictive modeling to support complex multi-criteria decisions based on multi-attribute utility theory (MAUT). A simplified two-step elicitation procedure consisting of an online survey and face-to-face interviews is followed by an extensive uncertainty analysis. This covers uncertainty of the preference components (marginal value and utility functions, hierarchical aggregation functions, aggregation parameters) and the attribute predictions. Context uncertainties about future socio-economic developments are captured by combining MAUT with scenario planning. We perform a global sensitivity analysis (GSA) to assess the contribution of single uncertain preference parameters to the uncertainty of the ranking of alternatives. This is exemplified for sustainable water infrastructure planning in a case study in Switzerland. We compare 11 water supply alternatives ranging from conventional water supply systems to novel technologies and management schemes regarding 44 objectives. Their performance is assessed for four future scenarios and 10 stakeholders from different backgrounds and decision-making levels. Despite uncertainty in the ranking of alternatives, potential best and worst solutions could be identified. We demonstrate that a priori assumptions such as linear value functions or additive aggregation can result in misleading recommendations, unless thoroughly checked during preference elicitation and modeling. We suggest GSA to focus elicitation on most sensitive preference parameters. Our GSA results indicate that output uncertainty can be considerably reduced by additional elicitation of few parameters, e.g. the overall risk attitude and aggregation functions at higher-level nodes. Here, rough value function elicitation was sufficient, thereby substantially reducing elicitation time.

Multiple-Criteria Decision Analysis Reveals High Stakeholder Preference to Remove Pharmaceuticals from Hospital Wastewater

Point-source measures have been suggested to decrease pharmaceuticals in water bodies. We analyzed 68 and 50 alternatives, respectively, for a typical Swiss general and psychiatric hospital to decrease pharmaceutical discharge. Technical alternatives included reverse osmosis, ozonation, and activated carbon; organizational alternatives included urine separation. To handle this complex decision, we used Multiple-Criteria Decision Analysis (MCDA) and combined expert predictions (e.g., costs, pharmaceutical mass flows, ecotoxicological risk, pathogen removal) with subjective preference-valuations from 26 stakeholders (authorities, hospital-internal actors, experts). The general hospital contributed ca. 38% to the total pharmaceutical load at the wastewater treatment plant, the psychiatry contributed 5%. For the general hospital, alternatives removing all pharmaceuticals (especially reverse osmosis, or vacuum-toilets and incineration), performed systematically better than the status quo or urine separation, despite higher costs. They now require closer scrutiny. To remove X-ray contrast agents, introducing roadbags is promising. For the psychiatry with a lower pharmaceutical load, costs were more critical. Stakeholder feedback concerning MCDA was very positive, especially because the results were robust across different stakeholder-types. Our MCDA results provide insight into an important water protection issue: implementing measures to decrease pharmaceuticals will likely meet acceptance. Hospital point-sources merit consideration if the trade-off between costs and pharmaceutical removal is reasonable.