Julie Anne Heath
Amgen
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Publication
Featured researches published by Julie Anne Heath.
Journal of Medicinal Chemistry | 2012
Xiaoqi Chen; David J. Kopecky; Jeff Mihalic; Shawn Jeffries; Xiaoshan Min; Julie Anne Heath; Jeff Deignan; SuJen Lai; Zice Fu; Cristiano R. W. Guimarães; Shanling Shen; Shyun Li; Sheree Johnstone; Stephen T. Thibault; Haoda Xu; Mario G. Cardozo; Wang Shen; Nigel Walker; Frank Kayser; Zhulun Wang
The eukaryotic initiation factor 4E (eIF4E) plays a central role in the initiation of gene translation and subsequent protein synthesis by binding the 5 terminal mRNA cap structure. We designed and synthesized a series of novel compounds that display potent binding affinity against eIF4E despite their lack of a ribose moiety, phosphate, and positive charge as present in m7-GMP. The biochemical activity of compound 33 is 95 nM for eIF4E in an SPA binding assay. More importantly, the compound has an IC(50) of 2.5 μM for inhibiting cap-dependent mRNA translation in a rabbit reticular cell extract assay (RRL-IVT). This series of potent, truncated analogues could serve as a promising new starting point toward the design of neutral eIF4E inhibitors with physicochemical properties suitable for cellular activity assessment.
Archive | 2011
Michael D. Bartberger; Ana Gonzalez Buenrostro; Hilary P. Beck; Xiaoqi Chen; Richard V. Connors; Jeffrey Deignan; Jason Duquette; John Eksterowicz; Benjamin Fisher; Brian M. Fox; Jiasheng Fu; Zice Fu; Felix Gonzalez-Lopez de Turiso; Michael W. Gribble; Darin Gustin; Julie Anne Heath; Xin Huang; Xianyun Jiao; Michael G. Johnson; Frank Kayser; David J. Kopecky; SuJen Lai; Yihong Li; Zhihong Li; Jiwen Liu; Jonathan D. Low; Brian Lucas; Zhihua Ma; Lawrence R. McGee; Joel McIntosh
Archive | 2012
Michael D. Bartberger; Hilary P. Beck; Xiaoqi Chen; Richard V. Connors; Jeffrey Deignan; Jason Duquette; John Eksterowicz; Brian M. Fox; Jiasheng Fu; Ana Gonzalez Buenrostro; Felix Gonzalez-Lopez de Turiso; Darin Gustin; Julie Anne Heath; Michael G. Johnson; Frank Kayser; David J. Kopecky; Yihong Li; Zhihong Li; Zhihua Ma; Joel McIntosh; Julio C. Medina; Jeffrey T. Mihalic; Steven H. Olson; Yosup Rew; Philip Roveto; Michael J. Schmitt; Daqing Sun; Xiaodong Wang; Malgorzata Wanska; Christine Weathers
Archive | 2018
Yinhong Chen; Paul John Dransfield; James S. Harvey; Julie Anne Heath; Jonathan B. Houze; Aarif Y. Khakoo; David J. Kopecky; SuJen Lai; Ma Zhihua; Nobuko Nishimura; Vatee Pattaropong; Gayathri Swaminath; Wen-Chen Yeh; Philip Dean Ramsden
Archive | 2017
Xiaoqi Chen; Yinhong Chen; Alan C. Cheng; Richard V. Connors; Mikkel V. Debenedetto; Paul John Dransfield; Fu Zice; James S. Harvey; Julie Anne Heath; Simon J. Hedley; Jonathan B. Houze; Ted Judd; Aarif Y. Khakoo; David J. Kopecky; SuJen Lai; Ma Zhihua; Nobuko Nishimura; Steven H. Olson; Vatee Pattaropong; Gayathri Swaminath; Xiaodong Wang; Wen-Chen Yeh
Archive | 2017
Chen Ning; Chen Xiaoqi; Chen Yinhong; Alan C. Cheng; Richard V. Connors; Mikkel V. Debenedetto; Jeffrey Deignan; Paul John Dransfield; Du Xiaohui; Robert P. Farrell; Fu Zice; Simon J. Hedley; Julie Anne Heath; Daniel B. Horne; Jonathan B. Houze; Ted Judd; Matthew R. Kaller; Kayser Frank; Aarif Y. Khakoo; David J. Kopecky; Lai Su Jen; Ma Zhihua; Lawrence R. McGee; Jurio C Medina; Jeffrey T. Mihalic; Nishimura Nobuko; Steven H. Olson; Vatee Pattaropong; Gayathri Swaminath; Wang Xiaodong
Archive | 2017
Ning Chen; Xiaoqi Chen; Richard V. Connors; Jeffrey Deignan; Paul John Dransfield; Xiaohui Du; Zice Fu; Julie Anne Heath; Daniel B. Horne; Jonathan B. Houze; Matthew R. Kaller; David J. Kopecky; SuJen Lai; Zhihua Ma; Lawrence R. McGee; Julio C. Medina; Jeffrey T. Mihalic; Nobuko Nishimura; Steven H. Olson; Vatee Pattaropong; Xiaodong Wang; Kevin Yang; Mikkel V. Debenedetto; Robert P. Farrell; Simon J. Hedley; Ted Judd
Archive | 2016
Wen Yeh; Kevin Chen Yang; Xiaodong Wang; Gayathri Swaminath; Vatee Pattaropong; Steven H. Olson; Nobuko Nishimura; Jeffrey T. Mihalic; Julio C. Medina; Lawrence R Mgee; Zhihua Ma; Su Lai; David J. Kopecky; Aarif Y. Khakoo; Frank Kayser; Matthew R. Kaller; Ted Judd; Jonathan B. Houze; Daniel B. Horne; Julie Anne Heath; Simon J. Hedley; Zice Fu; Robert P. Farrell; Xiaohui Du; Paul John Dransfield; Jeffrey Deignan; Mikkel V. Debenedetto; Richard V. Connors; Alan C. Cheng; Yinhong Chen
Archive | 2016
Ning Chen; Xiaoqi Chen; Yinhong Chen; Alan C. Cheng; Richard V. Connors; Jeffrey Deignan; Paul John Dransfield; Xiaohui Du; Zice Fu; Julie Anne Heath; Daniel B. Horne; Jonathan B. Houze; Matthew R. Kaller; Aarif Y. Khakoo; David J. Kopecky; SuJen Lai; Zhihua Ma; Lawrence R. McGee; Julio C. Medina; Jeffrey T. Mihalic; Nobuko Nishimura; Steven H. Olson; Vatee Pattaropong; Gayathri Swaminath; Xiaodong Wang; Kevin Yang; Wen-Chen Yeh; Mikkel V. Debenedetto; Robert P. Farrell; Simon J. Hedley
Archive | 2016
Ning Chen; Xiaoqi Chen; Richard V. Connors; Jeffrey Deignan; Paul John Dransfield; Xiaohui Du; Zice Fu; Julie Anne Heath; Daniel B. Horne; Jonathan B. Houze; Matthew R. Kaller; David J. Kopecky; SuJen Lai; Zhihua Ma; Lawrence R. McGee; Julio C. Medina; Jeffrey T. Mihalic; Nobuko Nishimura; Steven H. Olson; Vatee Pattaropong; Xiaodong Wang; Kevin Yang; Mikkel V. Debenedetto; Robert P. Farrell; Simon J. Hedley; Ted Judd
