Julie Park
Stanford University
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Publication
Featured researches published by Julie Park.
Genome Research | 2012
Alan P. Boyle; Eurie L. Hong; Manoj Hariharan; Yong Cheng; Marc A. Schaub; Maya Kasowski; Konrad J. Karczewski; Julie Park; Benjamin C. Hitz; Shuai Weng; J. Michael Cherry; Michael Snyder
As the sequencing of healthy and disease genomes becomes more commonplace, detailed annotation provides interpretation for individual variation responsible for normal and disease phenotypes. Current approaches focus on direct changes in protein coding genes, particularly nonsynonymous mutations that directly affect the gene product. However, most individual variation occurs outside of genes and, indeed, most markers generated from genome-wide association studies (GWAS) identify variants outside of coding segments. Identification of potential regulatory changes that perturb these sites will lead to a better localization of truly functional variants and interpretation of their effects. We have developed a novel approach and database, RegulomeDB, which guides interpretation of regulatory variants in the human genome. RegulomeDB includes high-throughput, experimental data sets from ENCODE and other sources, as well as computational predictions and manual annotations to identify putative regulatory potential and identify functional variants. These data sources are combined into a powerful tool that scores variants to help separate functional variants from a large pool and provides a small set of putative sites with testable hypotheses as to their function. We demonstrate the applicability of this tool to the annotation of noncoding variants from 69 full sequenced genomes as well as that of a personal genome, where thousands of functionally associated variants were identified. Moreover, we demonstrate a GWAS where the database is able to quickly identify the known associated functional variant and provide a hypothesis as to its function. Overall, we expect this approach and resource to be valuable for the annotation of human genome sequences.
Nucleic Acids Research | 2012
J. Michael Cherry; Eurie L. Hong; Craig Amundsen; Rama Balakrishnan; Gail Binkley; Esther T. Chan; Karen R. Christie; Maria C. Costanzo; Selina S. Dwight; Stacia R. Engel; Dianna G. Fisk; Jodi E. Hirschman; Benjamin C. Hitz; Kalpana Karra; Cynthia J. Krieger; Stuart R. Miyasato; Robert S. Nash; Julie Park; Marek S. Skrzypek; Matt Simison; Shuai Weng; Edith D. Wong
The Saccharomyces Genome Database (SGD, http://www.yeastgenome.org) is the community resource for the budding yeast Saccharomyces cerevisiae. The SGD project provides the highest-quality manually curated information from peer-reviewed literature. The experimental results reported in the literature are extracted and integrated within a well-developed database. These data are combined with quality high-throughput results and provided through Locus Summary pages, a powerful query engine and rich genome browser. The acquisition, integration and retrieval of these data allow SGD to facilitate experimental design and analysis by providing an encyclopedia of the yeast genome, its chromosomal features, their functions and interactions. Public access to these data is provided to researchers and educators via web pages designed for optimal ease of use.
Nucleic Acids Research | 2008
Midori A. Harris; Jennifer I. Deegan; Amelia Ireland; Jane Lomax; Michael Ashburner; Susan Tweedie; Seth Carbon; Suzanna E. Lewis; Christopher J. Mungall; John Richter; Karen Eilbeck; Judith A. Blake; Alexander D. Diehl; Mary E. Dolan; Harold Drabkin; Janan T. Eppig; David P. Hill; Ni Li; Martin Ringwald; Rama Balakrishnan; Gail Binkley; J. Michael Cherry; Karen R. Christie; Maria C. Costanzo; Qing Dong; Stacia R. Engel; Dianna G. Fisk; Jodi E. Hirschman; Benjamin C. Hitz; Eurie L. Hong
The Gene Ontology (GO) project (http://www.geneontology.org/) provides a set of structured, controlled vocabularies for community use in annotating genes, gene products and sequences (also see http://www.sequenceontology.org/). The ontologies have been extended and refined for several biological areas, and improvements to the structure of the ontologies have been implemented. To improve the quantity and quality of gene product annotations available from its public repository, the GO Consortium has launched a focused effort to provide comprehensive and detailed annotation of orthologous genes across a number of ‘reference’ genomes, including human and several key model organisms. Software developments include two releases of the ontology-editing tool OBO-Edit, and improvements to the AmiGO browser interface.
Nucleic Acids Research | 2007
Eurie L. Hong; Rama Balakrishnan; Qing Dong; Karen R. Christie; Julie Park; Gail Binkley; Maria C. Costanzo; Selina S. Dwight; Stacia R. Engel; Dianna G. Fisk; Jodi E. Hirschman; Benjamin C. Hitz; Cynthia J. Krieger; Michael S. Livstone; Stuart R. Miyasato; Robert S. Nash; Rose Oughtred; Marek S. Skrzypek; Shuai Weng; Edith D. Wong; Kathy K. Zhu; Kara Dolinski; David Botstein; J. Michael Cherry
The Saccharomyces Genome Database (SGD; http://www.yeastgenome.org/) collects and organizes biological information about the chromosomal features and gene products of the budding yeast Saccharomyces cerevisiae. Although published data from traditional experimental methods are the primary sources of evidence supporting Gene Ontology (GO) annotations for a gene product, high-throughput experiments and computational predictions can also provide valuable insights in the absence of an extensive body of literature. Therefore, GO annotations available at SGD now include high-throughput data as well as computational predictions provided by the GO Annotation Project (GOA UniProt; http://www.ebi.ac.uk/GOA/). Because the annotation method used to assign GO annotations varies by data source, GO resources at SGD have been modified to distinguish data sources and annotation methods. In addition to providing information for genes that have not been experimentally characterized, GO annotations from independent sources can be compared to those made by SGD to help keep the literature-based GO annotations current.
Nucleic Acids Research | 2010
Stacia R. Engel; Rama Balakrishnan; Gail Binkley; Karen R. Christie; Maria C. Costanzo; Selina S. Dwight; Dianna G. Fisk; Jodi E. Hirschman; Benjamin C. Hitz; Eurie L. Hong; Cynthia J. Krieger; Michael S. Livstone; Stuart R. Miyasato; Robert S. Nash; Rose Oughtred; Julie Park; Marek S. Skrzypek; Shuai Weng; Edith D. Wong; Kara Dolinski; David Botstein; J. Michael Cherry
The Saccharomyces Genome Database (SGD; http://www.yeastgenome.org) is a scientific database for the molecular biology and genetics of the yeast Saccharomyces cerevisiae, which is commonly known as baker’s or budding yeast. The information in SGD includes functional annotations, mapping and sequence information, protein domains and structure, expression data, mutant phenotypes, physical and genetic interactions and the primary literature from which these data are derived. Here we describe how published phenotypes and genetic interaction data are annotated and displayed in SGD.
Database | 2012
Rama Balakrishnan; Julie Park; Kalpana Karra; Benjamin C. Hitz; Gail Binkley; Eurie L. Hong; Julie Sullivan; Gos Micklem; J. Michael Cherry
The Saccharomyces Genome Database (SGD; http://www.yeastgenome.org/) provides high-quality curated genomic, genetic, and molecular information on the genes and their products of the budding yeast Saccharomyces cerevisiae. To accommodate the increasingly complex, diverse needs of researchers for searching and comparing data, SGD has implemented InterMine (http://www.InterMine.org), an open source data warehouse system with a sophisticated querying interface, to create YeastMine (http://yeastmine.yeastgenome.org). YeastMine is a multifaceted search and retrieval environment that provides access to diverse data types. Searches can be initiated with a list of genes, a list of Gene Ontology terms, or lists of many other data types. The results from queries can be combined for further analysis and saved or downloaded in customizable file formats. Queries themselves can be customized by modifying predefined templates or by creating a new template to access a combination of specific data types. YeastMine offers multiple scenarios in which it can be used such as a powerful search interface, a discovery tool, a curation aid and also a complex database presentation format. Database URL: http://yeastmine.yeastgenome.org
Nucleic Acids Research | 2006
Jodi E. Hirschman; Rama Balakrishnan; Karen R. Christie; Maria C. Costanzo; Selina S. Dwight; Stacia R. Engel; Dianna G. Fisk; Eurie L. Hong; Michael S. Livstone; Robert S. Nash; Julie Park; Rose Oughtred; Marek S. Skrzypek; Barry Starr; Chandra L. Theesfeld; Jennifer M. Williams; Rey Andrada; Gail Binkley; Qing Dong; Christopher Lane; Stuart R. Miyasato; Anand Sethuraman; Mark Schroeder; Mayank K. Thanawala; Shuai Weng; Kara Dolinski; David Botstein; J. Michael Cherry
Sequencing and annotation of the entire Saccharomyces cerevisiae genome has made it possible to gain a genome-wide perspective on yeast genes and gene products. To make this information available on an ongoing basis, the Saccharomyces Genome Database (SGD) () has created the Genome Snapshot (). The Genome Snapshot summarizes the current state of knowledge about the genes and chromosomal features of S.cerevisiae. The information is organized into two categories: (i) number of each type of chromosomal feature annotated in the genome and (ii) number and distribution of genes annotated to Gene Ontology terms. Detailed lists are accessible through SGDs Advanced Search tool (), and all the data presented on this page are available from the SGD ftp site ().
Nucleic Acids Research | 2007
Robert S. Nash; Shuai Weng; Benjamin C. Hitz; Rama Balakrishnan; Karen R. Christie; Maria C. Costanzo; Selina S. Dwight; Stacia R. Engel; Dianna G. Fisk; Jodi E. Hirschman; Eurie L. Hong; Michael S. Livstone; Rose Oughtred; Julie Park; Marek S. Skrzypek; Chandra L. Theesfeld; Gail Binkley; Qing Dong; Christopher Lane; Stuart R. Miyasato; Anand Sethuraman; Mark Schroeder; Kara Dolinski; David Botstein; J. Michael Cherry
The recent explosion in protein data generated from both directed small-scale studies and large-scale proteomics efforts has greatly expanded the quantity of available protein information and has prompted the Saccharomyces Genome Database (SGD; ) to enhance the depth and accessibility of protein annotations. In particular, we have expanded ongoing efforts to improve the integration of experimental information and sequence-based predictions and have redesigned the protein information web pages. A key feature of this redesign is the development of a GBrowse-derived interactive Proteome Browser customized to improve the visualization of sequence-based protein information. This Proteome Browser has enabled SGD to unify the display of hidden Markov model (HMM) domains, protein family HMMs, motifs, transmembrane regions, signal peptides, hydropathy plots and profile hits using several popular prediction algorithms. In addition, a physico-chemical properties page has been introduced to provide easy access to basic protein information. Improvements to the layout of the Protein Information page and integration of the Proteome Browser will facilitate the ongoing expansion of sequence-specific experimental information captured in SGD, including post-translational modifications and other user-defined annotations. Finally, SGD continues to improve upon the availability of genetic and physical interaction data in an ongoing collaboration with BioGRID by providing direct access to more than 82 000 manually-curated interactions.
Database | 2013
Cecilia N. Arighi; Ben Carterette; K. Bretonnel Cohen; Martin Krallinger; W. John Wilbur; Petra Fey; Robert Dodson; Laurel Cooper; Ceri E. Van Slyke; Wasila M. Dahdul; Paula M. Mabee; Donghui Li; Bethany Harris; Marc Gillespie; Silvia Jimenez; Phoebe M. Roberts; Lisa Matthews; Kevin G. Becker; Harold J. Drabkin; Susan M. Bello; Luana Licata; Andrew Chatr-aryamontri; Mary L. Schaeffer; Julie Park; Melissa Haendel; Kimberly Van Auken; Yuling Li; Juancarlos Chan; Hans-Michael Müller; Hong Cui
In many databases, biocuration primarily involves literature curation, which usually involves retrieving relevant articles, extracting information that will translate into annotations and identifying new incoming literature. As the volume of biological literature increases, the use of text mining to assist in biocuration becomes increasingly relevant. A number of groups have developed tools for text mining from a computer science/linguistics perspective, and there are many initiatives to curate some aspect of biology from the literature. Some biocuration efforts already make use of a text mining tool, but there have not been many broad-based systematic efforts to study which aspects of a text mining tool contribute to its usefulness for a curation task. Here, we report on an effort to bring together text mining tool developers and database biocurators to test the utility and usability of tools. Six text mining systems presenting diverse biocuration tasks participated in a formal evaluation, and appropriate biocurators were recruited for testing. The performance results from this evaluation indicate that some of the systems were able to improve efficiency of curation by speeding up the curation task significantly (∼1.7- to 2.5-fold) over manual curation. In addition, some of the systems were able to improve annotation accuracy when compared with the performance on the manually curated set. In terms of inter-annotator agreement, the factors that contributed to significant differences for some of the systems included the expertise of the biocurator on the given curation task, the inherent difficulty of the curation and attention to annotation guidelines. After the task, annotators were asked to complete a survey to help identify strengths and weaknesses of the various systems. The analysis of this survey highlights how important task completion is to the biocurators’ overall experience of a system, regardless of the system’s high score on design, learnability and usability. In addition, strategies to refine the annotation guidelines and systems documentation, to adapt the tools to the needs and query types the end user might have and to evaluate performance in terms of efficiency, user interface, result export and traditional evaluation metrics have been analyzed during this task. This analysis will help to plan for a more intense study in BioCreative IV.
Database | 2011
Maria C. Costanzo; Julie Park; Rama Balakrishnan; J. Michael Cherry; Eurie L. Hong
Annotation using Gene Ontology (GO) terms is one of the most important ways in which biological information about specific gene products can be expressed in a searchable, computable form that may be compared across genomes and organisms. Because literature-based GO annotations are often used to propagate functional predictions between related proteins, their accuracy is critically important. We present a strategy that employs a comparison of literature-based annotations with computational predictions to identify and prioritize genes whose annotations need review. Using this method, we show that comparison of manually assigned ‘unknown’ annotations in the Saccharomyces Genome Database (SGD) with InterPro-based predictions can identify annotations that need to be updated. A survey of literature-based annotations and computational predictions made by the Gene Ontology Annotation (GOA) project at the European Bioinformatics Institute (EBI) across several other databases shows that this comparison strategy could be used to maintain and improve the quality of GO annotations for other organisms besides yeast. The survey also shows that although GOA-assigned predictions are the most comprehensive source of functional information for many genomes, a large proportion of genes in a variety of different organisms entirely lack these predictions but do have manual annotations. This underscores the critical need for manually performed, literature-based curation to provide functional information about genes that are outside the scope of widely used computational methods. Thus, the combination of manual and computational methods is essential to provide the most accurate and complete functional annotation of a genome. Database URL: http://www.yeastgenome.org