Jutta Kockler
James Cook University
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Publication
Featured researches published by Jutta Kockler.
Profiles of Drug Substances, Excipients and Related Methodology | 2013
Jutta Kockler; Sherryl Robertson; Michael Oelgemöller; Murray S. Davies; Bruce F. Bowden; Harry G. Brittain; Beverley Glass
A comprehensive profile on Butyl methoxy dibenzoylmethane, one of the most commonly used ultraviolet (UV) filters in topical sunscreen products, is prepared. This UV filter, often referred to as Avobenzone, has its main absorbance in the UVA I region of the spectrum and is susceptible to photodegradation. The profile contains the following sections: general information, use and mechanism of action, method of preparation, physical characteristics, methods of analysis, stability, and toxicity. The physical characteristics section includes the melting range, differential scanning calorimetry, partition coefficient, ionization constant, solubility, and UV, infrared, nuclear magnetic resonance ((1)H NMR and (13)C NMR) and mass spectrometry and X-ray powder diffractometry. The method of analysis section in addition to compendial identification and purity and assay methods includes thin-layer gas and high-performance liquid chromatography. The photostability and photostabilization of Butyl methoxy dibenzoylmethane, in addition to its toxicity, are also documented.
Seizure-european Journal of Epilepsy | 2015
Nichola Redmayne; Sherryl Robertson; Jutta Kockler; Victoria Llewelyn; Alison Haywood; Beverley Glass
PURPOSE Sodium valproate, which is commonly repacked to assist with adherence to ensure seizure control, is hygroscopic and therefore sensitive to moisture. The aim of this study was thus to determine the stability implications of removing the enteric coated tablets from their original packaging and repackaging into a Dose Administration Aid (DAA) with storage under various environmental conditions. METHODS Physicochemical stability of enteric coated sodium valproate tablets repackaged into a DAA and stored at controlled room temperature, accelerated and refrigerated conditions was evaluated for 28 days. A validated high performance liquid chromatography method was used for the quantitation of the drug content. RESULTS Although the chemical stability (sodium valproate between 95 and 105% of labelled content) was maintained for 28 days for all storage conditions, for those tablets stored under accelerated conditions the integrity of the enteric coat was compromised after only 8 days. CONCLUSIONS Repackaging of enteric coated sodium valproate should be undertaken with caution and be informed by storage climate. This is particularly relevant for those patients living in hot, humid environments where they should be advised to store their DAA in a refrigerator.
Chromatographia | 2013
Jutta Kockler; Cherie A. Motti; Sherryl Robertson; Michael Oelgemöller; Beverley Glass
Butyl methoxy dibenzoylmethane (BMDM) and octocrylene (OC), common UV-filters in sunscreen products are often used in combination. Together they provide broad spectrum photoprotection from exposure to both UVA- and UVB-light. These UV-filters may, however, undergo photodegradation and generate photodegradants, resulting in a potential loss of photoprotection. It is thus a concern that the photostability testing as described by the ICH Guideline Q1B is not a requirement for sunscreen products in Australia, Europe or the USA. UV-filter photodegradants have in addition been shown to be toxic, highlighting the importance of their separation from the parent UV-filters. An HPLC method was developed and validated to quantitatively determine a combination of these UV-filters in the presence of their photodegradants. Reverse-phase chromatography was employed, using a C18 column and an isocratic mobile phase consisting of methanol/water/acetic acid (89/10/1 v/v). Validation according to the ICH guidelines for linearity, accuracy, precision, sensitivity, specificity and robustness was confirmed. The developed and validated method was then successfully applied to the determination of BMDM and OC in an aqueous cream base, typically used in sunscreens, after photostability testing, according to the ICH Guideline Q1B. In addition, the diketo-enol ratio of BMDM in methanol-d4 was determined by NMR and the two major photodegradants were identified by FTMS and LC–MS.
Journal of Photochemistry and Photobiology C-photochemistry Reviews | 2012
Jutta Kockler; Michael Oelgemöller; Sherryl Robertson; Beverley Glass
Applied Catalysis B-environmental | 2015
Devagi Kanakaraju; Jutta Kockler; Cherie A. Motti; Beverley Glass; Michael Oelgemöller
Cosmetics | 2014
Jutta Kockler; Michael Oelgemöller; Sherryl Robertson; Beverley Glass
Archive | 2012
Jutta Kockler; Devagi Kanakaraju; Beverley Glass; Michael Oelgemöller
Journal of pharmacy practice and research | 2013
Jutta Kockler; Sherryl Robertson; Denise Hope; Alison Haywood; Beverley Glass
Australian Journal of Pharmacy | 2014
Sherryl Robertson; Jutta Kockler; Alison Haywood; Beverley Glass
Archive | 2014
Jutta Kockler