K. Ambadipudi

Stokes parameter imaging of multi-index of refraction biological phantoms utilizing optically active molecular contrast agents

The purpose of this study is to assess the potential of novel molecular polarimetric imaging techniques utilizing multi-index of refraction targets, i.e. composite targets made from optically different media, immersed into biological fluids doped with optically active molecules and enzymes. The outcome of this study indicates that the application of Stokes parameter detection principles with concominant administration of fluids containing suitable optically active molecular contrast agents and high index of refraction molecules could enhance the detection and imaging process of internal structures by providing enhanced penetration depth, high contrast and high depolarized scatter rejection.

Efficient Molecular Imaging Techniques Using Optically Active Molecules

Efficient imaging techniques aimed at the increasing of the image contrast of a structure, surrounded by a scattering medium, using optically active and high index of refraction molecules as molecular contrast agents, are presented. Specifically, an enhanced degree of linear polarization (DOLP) target detection and imaging is obtained by doping the surrounding medium with molecular contrast agents consisting of aqueous glucose, aqueous alcohol, and salt molecules, in conjunction with advanced polarimetric imaging techniques. The outcome of this paper opens new horizons in the areas of imaging, with emphasis on medical arena, industry, and detection technology.

New Pathways Towards the Enhancement of the Image Quality

In this paper, experimental results and data analysis on a novel technique aimed at increasing the image quality of the target, surrounded by a scattering medium, is presented. Specifically, enhanced target detection has been obtained by doping the surrounding medium with molecular contrast agents, consisting polar molecules yielding to an enhanced contract and specificity of the target, utilizing advanced polarimetric imaging techniques.

Optical Active Molecules used as Molecular Contrast Agents for Enhanced Imaging

A novel technique aimed at increasing the image contrast of a structure surrounded by a scattering medium, using optically active molecules as molecular contrast agents, is presented. Specifically, enhanced target detection was obtained by doping the surrounding medium with molecular contrast agents, consisting of aqueous glucose molecules, in conjunction to advanced polarimetric imaging techniques. The outcome of this study opens new horizons in the areas of molecular imaging, early disease detection and cancer identification.

Enhanced Detection and Imaging based on Novel Molecular NanoPhotonics Principles

The results of this novel study, based on multipixel and single-pixel detection geometries, indicate that, significantly higher contrast target detection images have been obtained by doping the surrounding medium with active optical molecules, in conjunction to efficient polarimetric techniques, yielding to an enhanced contract and specificity of the target.

Molecular imaging of tissue with high-contrast multispectral photosensitizing polarimetric imaging techniques

Backscattered laser beam contributions from biological fluids doped with optically active molecules were measured utilizing single-detection autobalanced polarimetric detection principles. The outcome of this study indicates that both the Detective Quantum Efficiency (DQE) and the Degree of Linear polarization (DOLP) of backscattered optical signals increase with increasing the concentrations of molecular optically active dopants. This translates to enhanced signal-to-noise ratio and contrast.

Increased Visibility of Targets Submerged in Scattering Opaque Media and Polarimetric Techniques

The novelty of this paper is indicated by a series of experimental measurements aimed at enhancing the detectability of targets immersed in scattered solutions. The experimental results clearly show that polarimetric images of superior quality can be obtained by doping the background surrounding the target with polar or high-dielectric molecules, yielding an enhanced contrast and specificity of the target. In addition, it is observed that degree of linear polarization (DOLP) images exhibit superior image characteristics with respect to total intensity (S0) images with the increase in the concentration of the optical scattering agents.

Enhanced Detectability of Targets in Opaque Media

The novelty of this study consists in a series of experimental observations, indicating an improvement of the detectability of targets immersed in scattered solutions, by obtaining enhanced DOLP backscattered images over non-polarized backscattered images, with increasing the concentration of the scattering agent, therefore, the opacity of the medium.

Backscattered polarimetric detection from biological tissue

In this study, backscattering optical measurements from this scattering media and biological tissue were performed using different polarimetric detection techniques. The outcome of this study may facilitate the early diagnosis, monitoring, and assessment of disease progress, with high sensitivity and specificity.

Efficient Photosensitizers for Trans-illumination and Optical Imaging

The purpose of this study is to explore novel concepts of light enhancement mechanisms and trans-illumination imaging techniques. Specifically, the impact of glucose molecules, amino acids and other polar molecules on the light beam profile enhancement characteristics of a trans-illumination system, such as beam intensity, contrast resolution, signal-to-noise ratio and signal- to-background ratio have been studied, under a variety of experimental scenarios. The outcome of this study can be extended to a variety of clinical and diagnostic applications and techniques.