K. Valluru

Stokes parameter imaging of multi-index of refraction biological phantoms utilizing optically active molecular contrast agents

The purpose of this study is to assess the potential of novel molecular polarimetric imaging techniques utilizing multi-index of refraction targets, i.e. composite targets made from optically different media, immersed into biological fluids doped with optically active molecules and enzymes. The outcome of this study indicates that the application of Stokes parameter detection principles with concominant administration of fluids containing suitable optically active molecular contrast agents and high index of refraction molecules could enhance the detection and imaging process of internal structures by providing enhanced penetration depth, high contrast and high depolarized scatter rejection.

Efficient Molecular Imaging Techniques Using Optically Active Molecules

Efficient imaging techniques aimed at the increasing of the image contrast of a structure, surrounded by a scattering medium, using optically active and high index of refraction molecules as molecular contrast agents, are presented. Specifically, an enhanced degree of linear polarization (DOLP) target detection and imaging is obtained by doping the surrounding medium with molecular contrast agents consisting of aqueous glucose, aqueous alcohol, and salt molecules, in conjunction with advanced polarimetric imaging techniques. The outcome of this paper opens new horizons in the areas of imaging, with emphasis on medical arena, industry, and detection technology.

Optical Active Molecules used as Molecular Contrast Agents for Enhanced Imaging

A novel technique aimed at increasing the image contrast of a structure surrounded by a scattering medium, using optically active molecules as molecular contrast agents, is presented. Specifically, enhanced target detection was obtained by doping the surrounding medium with molecular contrast agents, consisting of aqueous glucose molecules, in conjunction to advanced polarimetric imaging techniques. The outcome of this study opens new horizons in the areas of molecular imaging, early disease detection and cancer identification.

Enhanced Detection and Imaging based on Novel Molecular NanoPhotonics Principles

The results of this novel study, based on multipixel and single-pixel detection geometries, indicate that, significantly higher contrast target detection images have been obtained by doping the surrounding medium with active optical molecules, in conjunction to efficient polarimetric techniques, yielding to an enhanced contract and specificity of the target.

Polarimetric imaging of multi-index of refraction biological phantoms utilizing efficient molecular optical imaging techniques

The purpose of this study is to introduce the potential of novel molecular imaging techniques assessing their performance utilizing multi-index of refraction targets, i.e. composite targets made from optically different media, immersed into biological liquid solutions doped with optically active molecules. The outcome of this study is that using polarimetric imaging in conjunction with novel contrast agents boosts the image quality.

Increased Visibility of Targets Submerged in Scattering Opaque Media and Polarimetric Techniques

The novelty of this paper is indicated by a series of experimental measurements aimed at enhancing the detectability of targets immersed in scattered solutions. The experimental results clearly show that polarimetric images of superior quality can be obtained by doping the background surrounding the target with polar or high-dielectric molecules, yielding an enhanced contrast and specificity of the target. In addition, it is observed that degree of linear polarization (DOLP) images exhibit superior image characteristics with respect to total intensity (S0) images with the increase in the concentration of the optical scattering agents.

Backscattered polarimetric detection from biological tissue

In this study, backscattering optical measurements from this scattering media and biological tissue were performed using different polarimetric detection techniques. The outcome of this study may facilitate the early diagnosis, monitoring, and assessment of disease progress, with high sensitivity and specificity.

Novel Optical Techniques for Efficient Stand off Detection of Backscattered Polarimetric Signatures from Cluttered Targets

Novel detection concepts aimed to enhance the detection/discrimination capabilities of targets surrounded by scattering/cluttered backgrounds have been presented. The experimental results of this study, acquired using laser beams to illuminate scenes at specific wavelengths and interrogate their respective reflectance spectral features, indicate that spectral degree of linear polarization (DOLP) image difference techniques, as well as near-pixel multispectral detection techniques provide enhanced detection with high discrimination capabilities

Enhanced Robotic Rover Imaging Sensors for Space Exploration

The novelty of this study consists on the design and exploration of the performance of an efficient active sensoroptical polarimetric system aimed to perform real-time detection and 1-d imaging of surface defects. The design of such imaging sensor system would be, among other factors, of paramount significance for remote robotic rover inspections, and repairs of spacecraft structures including thermal protection systems for surface damage. Experimental results indicate an enhancement of the backscattered imaging signal parameters.