Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where K. B. Chandran is active.

Publication


Featured researches published by K. B. Chandran.


Annals of Biomedical Engineering | 2005

Flow in prosthetic heart valves: State-of-the-art and future directions

Ajit P. Yoganathan; K. B. Chandran; Fotis Sotiropoulos

Since the first successful implantation of a prosthetic heart valve four decades ago, over 50 different designs have been developed including both mechanical and bioprosthetic valves. Today, the most widely implanted design is the mechanical bileaflet, with over 170,000 implants worldwide each year. Several different mechanical valves are currently available and many of them have good bulk forward flow hemodynamics, with lower transvalvular pressure drops, larger effective orifice areas, and fewer regions of forward flow stasis than their earlier-generation counterparts such as the ball-and-cage and tilting-disc valves. However, mechanical valve implants suffer from complications resulting from thrombus deposition and patients implanted with these valves need to be under long-term anti-coagulant therapy. In general, blood thinners are not needed with bioprosthetic implants, but tissue valves suffer from structural failure with, an average life-time of 10–12 years, before replacement is needed. Flow-induced stresses on the formed elements in blood have been implicated in thrombus initiation within the mechanical valve prostheses. Regions of stress concentration on the leaflets during the complex motion of the leaflets have been implicated with structural failure of the leaflets with bioprosthetic valves. In vivo and in vitro experimental studies have yielded valuable information on the relationship between hemodynamic stresses and the problems associated with the implants. More recently, Computational Fluid Dynamics (CFD) has emerged as a promising tool, which, alongside experimentation, can yield insights of unprecedented detail into the hemodynamics of prosthetic heart valves. For CFD to realize its full potential, however, it must rely on numerical techniques that can handle the enormous geometrical complexities of prosthetic devices with spatial and temporal resolution sufficiently high to accurately capture all hemodynamically relevant scales of motion. Such algorithms do not exist today and their development should be a major research priority. For CFD to further gain the confidence of valve designers and medical practitioners it must also undergo comprehensive validation with experimental data. Such validation requires the use of high-resolution flow measuring tools and techniques and the integration of experimental studies with CFD modeling.


Annals of Biomedical Engineering | 2004

Three-Dimensional Fluid-Structure Interaction Simulation of Bileaflet Mechanical Heart Valve Flow Dynamics

Rui Cheng; Y. Lai; K. B. Chandran

The wall shear stress induced by the leaflet motion during the valve-closing phase has been implicated with thrombus initiation with prosthetic valves. Detailed flow dynamic analysis in the vicinity of the leaflets and the housing during the valve-closure phase is of interest in understanding this relationship. A three-dimensional unsteady flow analysis past bileaflet valve prosthesis in the mitral position is presented incorporating a fluid-structure interaction algorithm for leaflet motion during the valve-closing phase. Arbitrary Lagrangian–Eulerian method is employed for incorporating the leaflet motion. The forces exerted by the fluid on the leaflets are computed and applied to the leaflet equation of motion to predict the leaflet position. Relatively large velocities are computed in the valve clearance region between the valve housing and the leaflet edge with the resulting relatively large wall shear stresses at the leaflet edge during the impact-rebound duration. Negative pressure transients are computed on the surface of the leaflets on the atrial side of the valve, with larger magnitudes at the leaflet edge during the closing and rebound as well. Vortical flow development is observed on the inflow (atrial) side during the valve impact-rebound phase in a location central to the leaflet and away from the clearance region where cavitation bubbles have been visualized in previously reported experimental studies.


Medical Image Analysis | 2006

Plaque development, vessel curvature, and wall shear stress in coronary arteries assessed by X-ray angiography and intravascular ultrasound

Andreas Wahle; John J. Lopez; Mark E. Olszewski; Sarah C. Vigmostad; K. B. Chandran; James D. Rossen; Milan Sonka

The relationships among vascular geometry, hemodynamics, and plaque development in the coronary arteries are complex and not yet well understood. This paper reports a methodology for the quantitative analysis of in vivo coronary morphology and hemodynamics, with particular emphasis placed on the critical issues of image segmentation and the automated classification of disease severity. We were motivated by the observation that plaque more often developed at the inner curvature of a vessel, presumably due to the relatively lower wall shear stress at these locations. The presented studies are based on our validated methodology for the three-dimensional fusion of intravascular ultrasound (IVUS) and X-ray angiography, introducing a novel approach for IVUS segmentation that incorporates a robust, knowledge-based cost function and a fully optimal, three-dimensional segmentation algorithm. Our first study shows that circumferential plaque distribution depends on local vessel curvature in the majority of vessels. The second study analyzes the correlation between plaque distribution and wall shear stress in a set of 48 in vivo vessel segments. The results were conclusive for both studies, with a stronger correlation of circumferential plaque thickness with local curvature than with wall shear stress. The inverse relationship between local wall shear stress and plaque thickness was significantly more pronounced (p<0.025) in vessel cross sections exhibiting compensatory enlargement (positive remodeling) without luminal narrowing than when the full spectrum of disease severity was considered. The inverse relationship was no longer observed in vessels where less than 35% of vessel cross sections remained without luminal narrowing. The findings of this study confirm, in vivo, the hypothesis that relatively lower wall shear stress is associated with early plaque development.


Annals of Biomedical Engineering | 2004

Fluid dynamic analysis in a human left anterior descending coronary artery with arterial motion.

S. D. Ramaswamy; Sarah C. Vigmostad; Andreas Wahle; Y. Lai; Mark E. Olszewski; Kathleen C. Braddy; Theresa M. H. Brennan; James D. Rossen; Milan Sonka; K. B. Chandran

A computational fluid dynamic (CFD) analysis is presented to describe local flow dynamics in both 3-D spatial and 4-D spatial and temporal domains from reconstructions of intravascular ultrasound (IVUS) and bi-plane angiographic fusion images. A left anterior descending (LAD) coronary artery segment geometry was accurately reconstructed and subsequently its motion was incorporated into the CFD model. The results indicate that the incorporation of motion had appreciable effects on blood flow patterns. The velocity profiles in the region of a stenosis and the circumferential distribution of the axial wall shear stress (WSS) patterns in the vessel are altered with the wall motion introduced in the simulation. The time-averaged axial WSS between simulations of steady flow and unsteady flow without arterial motion were comparable (−0.3 to 13.7 Pa in unsteady flow versus −0.2 to 10.1 Pa in steady flow) while the magnitudes decreased when motion was introduced (0.3–4.5 Pa). The arterial wall motion affects the time-mean WSS and the oscillatory shear index in the coronary vessel fluid dynamics and may provide more realistic predictions on the progression of atherosclerotic disease.


Journal of Biomechanical Engineering-transactions of The Asme | 1993

Flow Dynamics in the Human Aorta

K. B. Chandran

The aorta is the major blood vessel transporting blood pumped by the left ventricle to the systemic circulation. The tricuspid aortic value at the root of the aorta provides a centralized flow with nearly uniform velocity profile into the ascending aorta. The aorta consisting of the ascending limb, the aortic arch, and the descending segment is a vessel of complex geometry including curvature in multiple planes, branches and bifurcation as well as taper. The understanding of the development of blood flow in this distensible vessel has been the subject of several theoretical as well as experimental investigations. Flow development in the aorta and in the branch vessels has been of interest in delineating the role of wall shear stresses on the etiology of atherosclerosis. In this paper, a review of the current status on our understanding of the complex flow dynamics in the aorta is presented. With the advent of transesophageal echocardiography and magnetic resonance velocity mapping, further evidence of the presence of secondary flows even in the descending aorta has been reported. The importance of the effect of secondary flow in the descending aorta on the perfusion of distal blood vessels (such as superior mesenteric and renal arterial branches) as well as in the iliac bifurcation is also included in the discussion.


Journal of Biomechanics | 1983

Laser anemometry measurements of pulsatile flow past aortic valve prostheses

K. B. Chandran; G.N. Cabell; B. Khalighi; Ching-Jen Chen

Experimental results are presented on physiological pulsatile flow past caged ball and tilting disc aortic valve prostheses mounted in an axisymmetric chamber incorporated in a mock circulatory system. The measurements of velocity profiles and turbulent normal stresses during several times in a cardiac cycle were obtained using laser-Doppler anemometry. Our results show that with increased angle of opening for the tilting disc valves, a large but locally confined vortex is observed along the wall in the minor flow region throughout most of the cardiac cycle. The turbulent normal stresses measured downstream to the tilting disc in the minor flow region parallel to the tilt axis were found to be larger than those measured downstream to the caged ball valves. Comparison of measurements with steady flow at flow rates comparable to peak pulsatile flow rate show that the turbulent normal stresses are larger by a factor of two in pulsatile flow with a frequency of 1.2 Hz.


Journal of Biomechanics | 2000

Numerical study on the effect of secondary flow in the human aorta on local shear stresses in abdominal aortic branches.

Tanya Shipkowitz; V.G.J. Rodgers; Lee J. Frazin; K. B. Chandran

Flow in the aortic arch is characterized primarily by the presence of a strong secondary flow superimposed over the axial flow, skewed axial velocity profiles and diastolic flow reversals. A significant amount of helical flow has also been observed in the descending aorta of humans and in models. In this study a computational model of the abdominal aorta complete with two sets of outflow arteries was adapted for three-dimensional steady flow simulations. The flow through the model was predicted using the Navier-Stokes equations to study the effect that a rotational component of flow has on the general flow dynamics in this vascular segment. The helical velocity profile introduced at the inlet was developed from magnetic resonance velocity mappings taken from a plane transaxial to the aortic arch. Results showed that flow division ratios increased in the first set of branches and decreased in the second set with the addition of rotational flow. Shear stress varied in magnitude with the addition of rotational flow, but the shear stress distribution did not change. No regions of flow separation were observed in the iliac arteries for either case. Helical flow may have a stabilizing effect on the flow patterns in branches in general, as evidenced by the decreased difference in shear stress between the inner and outer walls in the iliac arteries.


Annals of Biomedical Engineering | 2008

Micro-scale Dynamic Simulation of Erythrocyte–Platelet Interaction in Blood Flow

T. AlMomani; H. S. Udaykumar; J. S. Marshall; K. B. Chandran

Platelet activation, adhesion, and aggregation on the blood vessel and implants result in the formation of mural thrombi. Platelet dynamics in blood flow is influenced by the far more numerous erythrocytes (RBCs). This is particularly the case in the smaller blood vessels (arterioles) and in constricted regions of blood flow (such as in valve leakage and hinge regions) where the dimensions of formed elements of blood become comparable with that of the flow geometry. In such regions, models to predict platelet motion, activation, aggregation and adhesion must account for platelet–RBC interactions. This paper studies platelet–RBC interactions in shear flows by performing simulations of micro-scale dynamics using a computational fluid dynamics (CFD) model. A level-set sharp-interface immersed boundary method is employed in the computations in which RBC and platelet boundaries are tracked on a two-dimensional Cartesian grid. The RBCs are assumed to have an elliptical shape and to deform elastically under fluid forces while the platelets are assumed to behave as rigid particles of circular shape. Forces and torques between colliding blood cells are modeled using an extension of the soft-sphere model for elliptical particles. RBCs and platelets are transported under the forces and torques induced by fluid flow and cell–cell and cell–platelet collisions. The simulations show that platelet migration toward the wall is enhanced with increasing hematocrit, in agreement with past experimental observations. This margination is seen to occur due to hydrodynamic forces rather than collisional forces or volumetric exclusion effects. The effect of fluid shear forces on the platelets increases exponentially as a function of hematocrit for the range of parameters covered in this study. The micro-scale analysis can be potentially employed to obtain a deterministic relationship between fluid forces and platelet activation and aggregation in blood flow past cardiovascular implants.


Annals of Biomedical Engineering | 2008

Dynamic Simulation of Bioprosthetic Heart Valves Using a Stress Resultant Shell Model

Hyunggun Kim; Jia Lu; Michael S. Sacks; K. B. Chandran

It is a widely accepted axiom that localized concentration of mechanical stress and large flexural deformation is closely related to the calcification and tissue degeneration in bioprosthetic heart valves (BHV). In order to investigate the complex BHV deformations and stress distributions throughout the cardiac cycle, it is necessary to perform an accurate dynamic analysis with a morphologically and physiologically realistic material specification for the leaflets. We have developed a stress resultant shell model for BHV leaflets incorporating a Fung-elastic constitutive model for in-plane and bending responses separately. Validation studies were performed by comparing the finite element predicted displacement and strain measures with the experimentally measured data under physiological pressure loads. Computed regions of stress concentration and large flexural deformation during the opening and closing phases of the cardiac cycle correlated with previously reported regions of calcification and/or mechanical damage on BHV leaflets. It is expected that the developed experimental and computational methodology will aid in the understanding of the complex dynamic behavior of native and bioprosthetic valves and in the development of tissue engineered valve substitutes.


Journal of Biomechanics | 1982

Physiological pulsatile flow experiments in a model of the human aortic arch

T.L. Yearwood; K. B. Chandran

An experimental investigation of physiologically relevant pulsatile flow in a model of the human aortic arch has been conducted. The model aortic arch flow chamber was fabricated in clear acrylic from an in situ casting of the human aorta and was incorporated in a mock-circulatory system. The model excluded the coronary sinuses and the three major branching arteries of the mid-arch region in order to concentrate only upon the effects of the multi-dimensional curvatures and tapering in the aorta. Furthermore, a flow straightening section was placed upstream to the flow chamber to eliminate any fluid disturbances created by the prosthetic aortic valve used in these studies. The qualitative flow visualization studies in the model aorta revealed the presence of strong secondary fluid motions near the inner wall. These helical flows dissipated during diastole, being greatly affected by the dramatic flow reversals which occurred along the inner wall at the onset of diastole. Quantitative studies were conducted using a three-sensor hot-film velocity probe to determine the axial, radial and tangential velocity components at various cross-sections in the aorta. The results showed rapid reversal of axial velocity near the inner wall at the onset of diastole.

Collaboration


Dive into the K. B. Chandran's collaboration.

Top Co-Authors

Avatar

David D. McPherson

University of Texas Health Science Center at Houston

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Hyunggun Kim

University of Texas Health Science Center at Houston

View shared research outputs
Top Co-Authors

Avatar

Ching-Jen Chen

Florida State University

View shared research outputs
Top Co-Authors

Avatar

Joseph H. Gorman

University of Pennsylvania

View shared research outputs
Top Co-Authors

Avatar

Robert C. Gorman

University of Pennsylvania

View shared research outputs
Researchain Logo
Decentralizing Knowledge