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Dive into the research topics where K.L. Lockard is active.

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Featured researches published by K.L. Lockard.


The Annals of Thoracic Surgery | 2014

Blood Pressure Control in Continuous Flow Left Ventricular Assist Devices: Efficacy and Impact on Adverse Events

Brent C. Lampert; Chad E. Eckert; Stephanie Weaver; Ana Scanlon; K.L. Lockard; C. Allen; N. Kunz; C. Bermudez; J.K. Bhama; M.A. Shullo; Robert L. Kormos; Mary Amanda Dew; Jeffrey J. Teuteberg

BACKGROUND Continuous flow (CF) left ventricular assist devices (LVAD) are afterload sensitive and therefore pump performance is affected by hypertension. In addition, poorly controlled hypertension may increase the risk of aortic insufficiency (AI) and stroke. Blood pressure regimens after CF LVAD have not been studied and their impact on rates of AI and stroke are unknown. METHODS Patients who had CF LVAD at a single center and were supported greater than 30 days were included. Blood pressure was monitored at home by Doppler. Outpatient management of blood pressure was conducted according to a predefined institutional protocol (target mean arterial pressure ≤ 80 mm Hg). RESULTS A total of 96 patients were included. At the end of follow-up, 25 patients were not on an antihypertensive drug, of these 9 died. Of the 74% receiving antihypertensives, 54% required 1 medication, 34% were on 2, 10% were on 3, and 3% were on 4 or more. Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers (85% of patients on an antihypertensive) and beta blockers (30%) were the most commonly prescribed medications. There was a significantly higher neurologic event rate in those on no antihypertensives compared with those on antihypertensives (p = 0.009). Only 3% of patients with no or mild AI at baseline progressed to develop moderate or greater AI after a mean of 201 days of follow-up. CONCLUSIONS Blood pressure control can be achieved in patients with CF LVADs, with the majority of patients requiring only 1 or 2 antihypertensives.


Journal of Cardiac Failure | 2018

Substantial Reduction in Driveline Infection Rates With the Modification of Driveline Dressing Protocol

Matthew M. Lander; N. Kunz; E. Dunn; Andrew D. Althouse; K.L. Lockard; M.A. Shullo; Robert L. Kormos; Jeffrey J. Teuteberg

BACKGROUND Driveline infection (DLI) is a cause of morbidity and mortality in patients with continuous-flow left ventricular assist devices (CF-LVADs). We hypothesized that an alternate dressing protocol would decrease the rate of DLIs. METHODS AND RESULTS A retrospective review of CF-LVAD implants at a single institution from January 2010 to October 2015 was conducted. Patients were divided into implants before (group 1) and after (group 2) the introduction of the new protocol on September 1, 2012. Patients were followed until death, transplantation, change in dressing type, or 2 years. 153 patients were included: 61 in group 1 and 92 in group 2. Group 1 had fewer HVADs than group 2 (27.9% vs 71.7%; P < .001) and more destination therapy, although the latter was not statistically significant (50.8% vs 34.8%; P = .118). At 24 months, the freedom from DLI was 53% in group 1 and 89% in group 2 (P = .01). Group 1 had a significantly greater risk of DLI than group 2 (incident rate ratio 3.18, 95% confidence interval 1.23-8.18; P = .016). CONCLUSIONS Dramatic improvement in freedom from DLI at 2 years was achieved with a new driveline dressing protocol. This demonstrates that DLI rates can be improved with alternate percutaneous site care techniques in CF-LVAD patients.


Journal of Heart and Lung Transplantation | 2009

5: Lack of Improvement in Prealbumin at Two Weeks Predicts a Poor Outcome after Mechanical Circulatory Support

K.L. Lockard; Lori DeGore; P. Schwarm; S. Winowich; G.C. O'Shea; Michael P. Siegenthaler; Marc A. Simon; Robert L. Kormos; J.J. Teuteberg


Journal of Heart and Lung Transplantation | 2013

Management of Anticoagulation in Patients with Mechanical Circulatory Support Using a Physician-Based Versus a Pharmacist Directed Anticoagulation Clinic-Based Strategy

J.J. Teuteberg; Robert L. Kormos; K.L. Lockard; N. Kunz; C. Allen; A. Scanlon; S. Weaver; D. Hall; C. Bermudez; M.A. Shullo


Journal of Heart and Lung Transplantation | 2009

250: Pre-VAD Implant Risk Factors Influence the Onset of Adverse Events (AEs) while on a VAD

Robert L. Kormos; J.J. Teuteberg; Michael P. Siegenthaler; S.A. Marc; Joy Kay; Elizabeth A. Genovese; C. Bermudez; Yoshiya Toyoda; K.L. Lockard; S. Winowich


Journal of Heart and Lung Transplantation | 2012

734 Blood Pressure Control in Continuous Flow Left Ventricular Assist Devices – Efficacy and Impact on Adverse Events

Brent C. Lampert; S. Weaver; A. Scanlon; K.L. Lockard; C. Allen; N. Kunz; C. Bermudez; J.K. Bhama; M.A. Shullo; Robert L. Kormos; J.J. Teuteberg


Journal of Heart and Lung Transplantation | 2013

Post Discharge Non-Compliance Increases Risk of Left Ventricular Assist Device (LVAD) Malfunction but Does Not Affect Survival

A. Hackmann; K.L. Lockard; C. Allen; N. Kunz; K. Jackson; J.K. Bhama; C. Bermudez; J.J. Teuteberg; Robert L. Kormos


Journal of Heart and Lung Transplantation | 2008

301: Ventricular Assist Device (VAD) Adverse Events (AE’s) Effect Not Only VAD Survival but Subsequent Survival after Cardiac Transplantation (CTX)

Joy Kay; J.J. Teuteberg; Marc A. Simon; Michael P. Siegenthaler; Elizabeth A. Genovese; C. Bermudez; J.K. Bhama; Mary Amanda Dew; K.L. Lockard; S. Winowich; Robert L. Kormos


Journal of Heart and Lung Transplantation | 2018

Spousal Support Does Not Affect Outcomes in Patients with Continuous Flow Left Ventricular Assist Device

A. Topoll; Andrew D. Althouse; K.L. Lockard; E. Dunn; N. Kunz; Mary Amanda Dew; A. Kilic; Christopher M. Sciortino; Michael A. Mathier; M.A. Shullo; Robert L. Kormos; G. Hickey.


Journal of Heart and Lung Transplantation | 2017

(500) - Temporal Patterns of Adverse Events (AE) Occurring within 60 Days of LVAD Implantation: The Concept of the AE Cascade

J. Larsen; Andrew D. Althouse; J.J. Teuteberg; Christopher M. Sciortino; Christine V Nikas; L.F. Lagazzi; Michael S. Sharbaugh; S.U. Iturra; N. Kunz; E. Dunn; K.L. Lockard; Robert L. Kormos

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J.J. Teuteberg

University of Pittsburgh

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C. Bermudez

University of Pennsylvania

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J.K. Bhama

University of Pittsburgh

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N. Kunz

University of Pittsburgh

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M.A. Shullo

University of Pittsburgh

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Marc A. Simon

University of Pittsburgh

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E. Dunn

University of Pittsburgh

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C. Allen

University of Pittsburgh

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