K.R. Ridderinkhof

Effective connectivity reveals important roles for both the hyperdirect (fronto-subthalamic) and the indirect (fronto-striatal-pallidal) fronto-basal ganglia pathways during response inhibition.

Fronto-basal ganglia pathways play a crucial role in voluntary action control, including the ability to inhibit motor responses. Response inhibition might be mediated via a fast hyperdirect pathway connecting the right inferior frontal gyrus (rIFG) and the presupplementary motor area (preSMA) with the subthalamic nucleus or, alternatively, via the indirect pathway between the cortex and caudate. To test the relative contribution of these two pathways to inhibitory action control, we applied an innovative quantification method for effective brain connectivity. Functional magnetic resonance imaging data were collected from 20 human participants performing a Simon interference task with an occasional stop signal. A single right-lateralized model involving both the hyperdirect and indirect pathways best explained the pattern of brain activation on stop trials. Notably, the overall connection strength of this combined model was highest on successfully inhibited trials. Inspection of the relationship between behavior and connection values revealed that fast inhibitors showed increased connectivity between rIFG and right caudate (rCaudate), whereas slow inhibitors were associated with increased connectivity between preSMA and rCaudate. In compliance, connection strengths from the rIFG and preSMA into the rCaudate were correlated negatively. If participants failed to stop, the magnitude of experienced interference (Simon effect), but not stopping latency, was predictive for the hyperdirect–indirect model connections. Together, the present results suggest that both the hyperdirect and indirect pathways act together to implement response inhibition, whereas the relationship between performance control and the fronto-basal ganglia connections points toward a top-down mechanism that underlies voluntary action control.

A study of adaptive behavior: effects of age and irrelevant information on the ability to inhibit one's actions.

Abstract In the study of adaptive behavior, the stop-signal paradigm provides a measure of the efficiency of response suppression that lends itself to examining the ability to inhibit ones actions, and two complementary types of factors that may influence that ability. Based on neurobiological considerations, age-related individual differences were hypothesized to be such a factor. In agreement with the the cognitive-neuroscience literature, which emphasizes the relatively late maturation and early senescence of the (pre)frontal brain structures that are crucial for inhibitory control, results are reported of a study demonstrating that response inhibition in the stop task is subject to an unequivocal age trend during child development. Stop task performance was hypothesized to be influenced further by the effects of irrelevant information. In a concurrent reaction time task, distractor stimuli may induce activation of an incorrect response. The subsequent inhibition of this incorrect response activation may interact with the suppression of responses in the stop task, if both are engaged simultaneously. Indeed, in a study designed to examine this prediction, the operation of response inhibition in the primary-task and stop processes affected one another negatively when distractors were associated with the incorrect response.

Limits on the application of additive factors logic: Violations of stage robustness suggest a dual-process architecture to explain flanker effects on target processing.

Abstract This study aimed to establish whether the logic of the AFM applies when multielement stimuli contain relevant and irrelevant elements. Target Size (TS) and symbolic S-R Compatibility (SRC) were manipulated in three reaction time (RT) experiments. TS and SRC are assumed in the AFM literature to selectively influence the independent stages of feature extraction and S-R translation, respectively. Experiment 1 showed that the effects of TS and SRC on RT were additive when the target was presented in isolation and this additive relation was not changed when the target was flanked by stimuli that contained no information relevant to the response. In Experiment 2, this additivity changed into a superadditive interaction when flankers signaled the same response as the target: The effect of SRC was larger when targets were small rather than large. The overall pattern of findings violated the AFM stage robustness criterion. Neither a discrete stage model nor a continuous flow conception account for the results. To explain flanker effects on target processing a dual-process architecture was formulated that assumes that perceptual information is processed along concurrently engaged routes: An attentive processing route and a direct priming route. Experiment 3 confirmed the prediction of the dual-process model that the relation between TS and SRC would be subadditive when flankers signal the response opposite to that designated by the target.

Mental resources, processing speed, and inhibitory control: A developmental perspective

The present article addresses the claim that the speed of information processing qualifies as a processing resource. This claim contends that age-related changes in processing speed pertain to all cognitive processes to the same proportional degree. That is, processing speed is compared to the clock speed of a microcomputer: as young childrens clock speed increases, the speed of processing in all cognitive processes increases until the adult level is reached. Re-analyses of recent behavioral and psychophysiological data provide evidence against the notion that development is characterized by an increase in childrens global clock speed, and refute the claim that processing speed operates as a mental resource on which all cognitive processes depend to the same extent. Rather, the results emphasize the role of inhibitory control in cognitive development, and we consider the relevance of inhibitory development to the issue of age-related changes in processing capacity.

Auditory and visual cortical activity during selective attention in fragile X syndrome: A cascade of processing deficiencies

OBJECTIVEnThis study examined whether attention deficits in fragile X syndrome (FXS) can be traced back to abnormalities in basic information processing.nnnMETHODnSixteen males with FXS and 22 age-matched control participants (mean age 29 years) performed a standard oddball task to examine selective attention in both auditory and visual modalities. Five FXS males were excluded from analysis because they performed below chance level on the auditory task. ERPs were recorded to investigate the N1, P2, N2b, and P3b components.nnnRESULTSnN1 and N2b components were significantly enhanced in FXS males to both auditory and visual stimuli. Interestingly, in FXS males, the P3b to auditory stimuli was significantly reduced relative to visual stimuli. These modality differences in information processing corresponded to behavioral results, showing more errors on the auditory than on the visual task.nnnCONCLUSIONSnThe current findings suggest that attentional impairments in FXS at the behavioral level can be traced back to abnormalities in event-related cortical activity. These information processing abnormalities in FXS may hinder the allocation of attentional resources needed for optimal processing at higher-levels.nnnSIGNIFICANCEnThese findings demonstrate that auditory information processing in FXS males is critically impaired relative to visual information processing.

Auditory change detection in fragile X syndrome males: A brain potential study

OBJECTIVEnThe present study investigated involuntary change detection in a two-tone pre-attentive auditory discrimination paradigm in order to better understand the information processing mechanisms underlying attention deficits in fragile X syndrome (FXS) males.nnnMETHODSnSixteen males with the FXS full mutation and 20 age-matched control participants (mean age 29 years) were presented with series of auditory stimuli consisting of standard and deviant tones while watching a silent movie.nnnRESULTSnBrain potentials recorded to the tones showed that N1 and P2, sensory evoked potentials, were significantly enhanced in FXS compared to age-matched control participants. In contrast to controls, the N1 to standard tones failed to show long-term habituation to stimulus repetition in FXS. Additionally, both mismatch negativity and P3a generation, reflecting automatic change detection and the involuntary switch of attention, respectively, were significantly attenuated in FXS males.nnnCONCLUSIONSnThe current study demonstrates that auditory stimulus discrimination in the FXS brain is already compromised during the pre-attentive stages of information processing. Furthermore, the apparent pre-attentive information processing deficiencies in FXS coincide with a weakness in the involuntary engagement of attentional resources.nnnSIGNIFICANCEnThe stimulus-driven information processing deficiencies in FXS might compromise information processing in several domains and, thus, present a key-deficit in FXS neurocognition.

Impaired inhibition of prepotent motor actions in patients with Tourette syndrome

BACKGROUNDnEvidence that tic behaviour in individuals with Tourette syndrome reflects difficulties inhibiting prepotent motor actions is mixed. Response conflict tasks produce sensitive measures of response interference from prepotent motor impulses and the proficiency of inhibiting these impulses as an act of cognitive control. We tested the hypothesis that individuals with Tourette syndrome show a deficit in inhibiting prepotent motor actions.nnnMETHODSnHealthy controls and older adolescents/adults with persistent Tourette syndrome without a history of obsessive-compulsive disorder or attention-deficit/hyperactivity disorder and presenting with stable mood functioning (i.e., no history of well-treated anxiety or depression) participated in this study. They performed a Simon task that induced conflict between prepotent actions and goal-directed actions. A novel theoretical framework distinguished group differences in acting impulsively (i.e., fast motor errors) from the proficiency of inhibiting interference by prepotent actions (i.e., slope of interference reduction).nnnRESULTSnWe included 27 controls and 28 individuals with Tourette syndrome in our study. Both groups showed similar susceptibility to making fast, impulsive motor errors (Tourette syndrome 26% v. control 23%; p = 0.10). The slope (m) reduction of the interference effect was significantly less pronounced among participants with Tourette syndrome than controls (Tourette syndrome: m = -0.07 v. control: m = -0.23; p = 0.022), consistent with deficient inhibitory control over prepotent actions in Tourette syndrome.nnnLIMITATIONSnThis study does not address directly the role of psychiatric comorbidities and medication effects on inhibitory control over impulsive actions in individuals with Tourette syndrome.nnnCONCLUSIONnThe results offer empirical evidence for deficient inhibitory control over prepotent motor actions in individuals with persistent Tourette syndrome with minimal to absent psychiatric comorbidities. These findings also suggest that the frontal-basal ganglia circuits involved in suppressing unwanted motor actions may underlie deficient inhibitory control abilities in individuals with Tourette syndrome.

Attentional set-shifting in fragile X syndrome

The ability to flexibly adapt to the changing demands of the environment is often reported as a core deficit in fragile X syndrome (FXS). However, the cognitive processes that determine this attentional set-shifting deficit remain elusive. The present study investigated attentional set-shifting ability in fragile X syndrome males with the well-validated intra/extra dimensional set-shifting paradigm (IED) which offers detailed assessment of rule learning, reversal learning, and attentional set-shifting ability within and between stimulus dimensions. A novel scoring method for IED stage errors was employed to interpret set-shifting failure in terms of repetitive decision-making, distraction to irrelevance, and set-maintenance failure. Performance of FXS males was compared to typically developing children matched on mental age, adults matched on chronological age, and individuals with Down syndrome matched on both mental and chronological age. Results revealed that a significant proportion of FXS males already failed prior to the intra-dimensional set-shift stage, whereas all control participants successfully completed the stages up to the crucial extra-dimensional set-shift. FXS males showed a specific weakness in reversal learning, which was characterized by repetitive decision-making during the reversal of newly acquired stimulus-response associations in the face of simple stimulus configurations. In contrast, when stimulus configurations became more complex, FXS males displayed increased distraction to irrelevant stimuli. These findings are interpreted in terms of the cognitive demands imposed by the stages of the IED in relation to the alleged neural deficits in FXS.

Preventing (impulsive) errors

Abstract In a rich environment, with multiple action affordances, selective action inhibition is critical in preventing the execution of inappropriate responses. Here, we studied the origin and the dynamics of incorrect response inhibition and how it can be modulated by task demands. We used EEG in a conflict task where the probability of compatible and incompatible trials was varied. This allowed us to modulate the strength of the prepotent response, and hence to increase the risk of errors, while keeping the probability of the two responses equal. The correct response activation and execution was not affected by compatibility or by probability. In contrast, incorrect response inhibition in the primary motor cortex ipsilateral to the correct response was more pronounced on incompatible trials, especially in the condition where most of the trials were compatible, indicating a modulation of inhibitory strength within the course of the action. Two prefrontal activities, one medial and one lateral, were also observed before the response, and their potential links with the observed inhibitory pattern observed are discussed.

Easy to learn, hard to suppress: The impact of learned stimulus-outcome associations on subsequent action control

The inhibition of impulsive response tendencies that conflict with goal-directed action is a key component of executive control. An emerging literature reveals that the proficiency of inhibitory control is modulated by expected or unexpected opportunities to earn reward or avoid punishment. However, less is known about how inhibitory control is impacted by the processing of task-irrelevant stimulus information that has been associated previously with particular outcomes (reward or punishment) or response tendencies (action or inaction). We hypothesized that stimulus features associated with particular action-valence tendencies, even though task irrelevant, would modulate inhibitory control processes. Participants first learned associations between stimulus features (color), actions, and outcomes using an action-valence learning task that orthogonalizes action (action, inaction) and valence (reward, punishment). Next, these stimulus features were embedded in a Simon task as a task-irrelevant stimulus attribute. We analyzed the effects of action-valence associations on the Simon task by means of distributional analysis to reveal the temporal dynamics. Learning patterns replicated previously reported biases; inherent, Pavlovian-like mappings (action-reward, inaction-punishment avoidance) were easier to learn than mappings conflicting with these biases (action-punishment avoidance, inaction-reward). More importantly, results from two experiments demonstrated that the easier to learn, Pavlovian-like action-valence associations interfered with the proficiency of inhibiting impulsive actions in the Simon task. Processing conflicting associations led to more proficient inhibitory control of impulsive actions, similar to Simon trials without any association. Fast impulsive errors were reduced for trials associated with punishment in comparison to reward trials or trials without any valence association. These findings provide insight into the temporal dynamics of task irrelevant information associated with action and valence modulating cognitive control. We discuss putative mechanisms that might explain these interactions.