K. Thomas Robbins

Carcinoma of the supraglottic larynx: Treatment results with radiotherapy alone or with planned neck dissection

To present the results of radiotherapy with or without neck dissection for squamous cell carcinoma of the supraglottic larynx treated at the University of Florida and to compare these data with those obtained after conservation surgery.

Swallowing and speech ability after treatment for head and neck cancer with targeted intraarterial versus intravenous chemoradiation

RADPLAT (concurrent selective supradose intraarterial cisplatin and external‐beam irradiation) delivers extraordinarily high cisplatin concentration to head and neck structures. This study was designed to quantify and compare RADPLAT and systemic chemoradiation treatment effects on swallowing and speech.

Neck level–specific nodal metastases in oropharyngeal cancer: Is there a role for selective neck dissection after definitive radiation therapy?

To determine the extent of the required neck dissection for patients with persistent lymphadenopathy after definitive radiation therapy for oropharyngeal cancer. If feasible, a conservative approach using selective neck dissection would likely minimize the extent of neck fibrosis and other adverse sequelae.

The use and misuse of neck dissection for head and neck cancer

Management of the Carotid Artery in Neck Dissection Neck dissection, or cervical lymphadenectomy, is a time-honored procedure used to treat metastastic carcinoma to the neck. Under most circumstances, the site of origin lies within the upper aerodigestive tract, thyroid gland, salivary glands, or the surrounding cutaneous structures. Contemporary approaches to neck surgery have included modifications of the classical radical neck dissection involving preservation of certain lymphatic regions, sparing nonlymphatic structures, or in some situations, removal of additional structures. As other modalities are proving to be effective treatment strategies for metastatic neck cancer, there is also a pressing need to define the role of neck dissection as part of a multimodality approach. Given this evolving role of neck dissection, this article is intended to outline the use and, in some situations, the misuse of these procedures in the management of patients with head and neck carcinoma. We served as panelists when this topic was presented at the annual meeting of the American College of Surgeons, October 2000.

Management of the neck in cancer of the major salivary glands, thyroid and parathyroid glands.

Management of the neck in cancer of the major salivary glands, thyroid and parathyroid glands

Current considerations in neck dissection

(2002). Current Considerations in Neck Dissection. Acta Oto-Laryngologica: Vol. 122, No. 3, pp. 323-329.

Current management of cutaneous malignant melanoma of the head and neck

(2002). Current Management of Cutaneous Malignant Melanoma of the Head and Neck. Acta Oto-Laryngologica: Vol. 122, No. 8, pp. 900-906.

Is it Time to Eliminate Confusion Regarding Cervical Lymph Node Levels According to the Scheme Originated at the Memorial Sloan-Kettering Cancer Center?

ALFIO FERLITO, K. THOMAS ROBBINS, JESUS E. MEDINA, ASHOK R. SHAHA, PETER M. SOM and ALESSANDRA RINALDO From the Department of Otolaryngology—Head and Neck Surgery, University of Udine, Udine, Italy, Department of Otolaryngology, University of Florida, Gainesville, Florida, USA, Department of Otolaryngology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA, Head and Neck Service, Memorial Sloan–Kettering Cancer Center, New York, New York, USA, Department of Radiology, Mount Sinai School of Medicine, City University of New York, New York, New York, USA

Reply to the letter to the editor by Straetmans et al

7. Weiss D, Koopmann M, Rudack C. Prevalence and impact on clinicopa-thological characteristics of human papillomavirus-16 DNA in cervicallymph node metastases of head and neck squamous cell carcinoma.Head Neck 2011;33:856–862.8. Armas GL, Su CY, Huang CC, Fang FM, Chen CM, Chien CY. Theimpact of virus in N3 node dissection for head and neck cancer. EurArch Otorhinolaryngol 2008;265:1379–1384.9. Barwad A, Sood S, Gupta N, Rajwanshi A, Panda N, Srinivasan R.Human papilloma virus associated head and neck cancer: a PCR basedstudy. Diagn Cytopathol 2011;Epub ahead of print.10. Hoffmann M, Gottschlich S, G€or €ogh T, et al. Human papillomaviruses inlymph node neck metastases of head and neck cancers. Acta Otolaryngol2005;125:415–421.11. Desai PC, Jaglal MV, Gopal P, et al. Human papillomavirus in metastaticsquamous carcinoma from unknown primaries in the head and neck: a ret-rospective 7 year study. Exp Mol Pathol 2009;87:94–98.12. Compton AM, Moore-Medlin T, Herman-Ferdinandez L, et al. Humanpapillomavirus in metastatic lymph nodes from unknown primary headand neck squamous cell carcinoma. Otolaryngol Head Neck Surg 2011;145:51–57.

High-Dose Intraarterial Chemotherapy/Radiation for Advanced Head and Neck Cancer

Publisher Summary This chapter focuses on RADPLAT therapy, which refers to a high-dose cisplatin intraarterial (IA) chemoradiation protocol developed to treat patients with advanced head and neck cancer. This targeted supradose cisplatin program appears to provide a lasting state of disease control for patients with T3-T4 resectable lesions without sacrificing the function of major organs and for patients with massive unresectable cancers. The treatment program incorporates a novel technique for infusing cisplatin directly into the tumor bed while minimizing the effects of the drug systemically. This is achieved by using microcatheters placed angiographically to permit superselective rapid infusions while sodium thiosulfate, a neutralizing agent for cisplatin, is simultaneously infused systemically. This approach is proving to be particularly effective for treating lesions that are otherwise difficult to manage, such as those in patients with massive lymphadenopathy (N3 disease), advanced paranasal sinus cancer, and temporal bone malignancies. Results from the IA trials are variable, but several studies, particularly those using cisplatin-based regimens, indicate that a high response rate can be achieved. Randomized trials may be indicated to determine whether this approach can increase survival, maintain organ function, and improve upon the quality of life relative to other chemoradiotherapy protocols.