Kalan R. Prudhomme
Oregon State University
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Featured researches published by Kalan R. Prudhomme.
Molecular Nutrition & Food Research | 2016
Hyemee Kim; Nivedita Banerjee; Ivan Ivanov; Catherine Pfent; Kalan R. Prudhomme; William H. Bisson; Roderick H. Dashwood; Stephen T. Talcott; Susanne U. Mertens-Talcott
SCOPE Tannin-rich fruits have been evaluated as alternative prevention strategies for colorectal cancer based on their anti-inflammatory properties. This study compared tannin-rich preparations from mango (rich in gallotannins) and pomegranate (rich in ellagitannins) in the dextran sodium sulfate-induced colitis model. METHODS AND RESULTS In rats, mango and pomegranate beverages decreased intestinal inflammation and the levels of pro-inflammatory cytokines in mucosa and serum. The mango beverage suppressed the ratio of phosphorylated/total protein expression of the IGF-1R-AKT/mTOR axis and downregulated mRNA expression of Igf1, Insr, and pik3cv. Pomegranate decreased p70S6K and RPS6, as well as Rps6ka2, Map2k2, and Mapk1 mRNA. In silico modeling indicated a high binding of docked of gallic acid to the catalytic domain of IGF-1R, which may suppress the activity of the enzyme. Ellagic acid docked effectively into the catalytic domains of both IGF-1R and EGFR. In vitro assays with lipopolysaccharide-treated CCD-18Co cells using polyphenolic extracts from each beverage, as well as pure compounds, corroborated the predictions made in silico. CONCLUSION Mango polyphenols inhibited the IGF-1R- AKT/mTOR axis, and pomegranate polyphenols downregulate the mTOR downstream pathway through reductions in ERK1/2. These results suggest that extracts rich in gallo- and ellagitannins act on different molecular targets in the protection against ulcerative colitis.
Carcinogenesis | 2015
Zhiwei Hu; Samira A. Brooks; Valérian Dormoy; Chia Wen Hsu; Hsue Yin Hsu; Liang Tzung Lin; Thierry Massfelder; W.Kimryn Rathmell; Menghang Xia; Fahd Al-Mulla; Rabeah Al-Temaimi; Amedeo Amedei; Dustin G. Brown; Kalan R. Prudhomme; Annamaria Colacci; Roslida A. Hamid; Chiara Mondello; Jayadev Raju; Elizabeth P. Ryan; Jordan Woodrick; A.Ivana Scovassi; Neetu Singh; Monica Vaccari; Rabindra Roy; Stefano Forte; Lorenzo Memeo; Hosni K. Salem; Leroy Lowe; Lasse Jensen; William H. Bisson
Molecular Nutrition & Food Research | 2016
Hyemee Kim; Nivedita Banerjee; Ivan Ivanov; Catherine Pfent; Kalan R. Prudhomme; William H. Bisson; Roderick H. Dashwood; Stephen T. Talcott; Susanne U. Mertens-Talcott