Karen Sutherland | Researchain

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Featured researches published by Karen Sutherland.

Organic Process Research & Development | 2011

A Safe and Practical Procedure for the Difluoromethylation of Methyl 4-Hydroxy-3-iodobenzoate

Jeffrey B. Sperry; Karen Sutherland

Organic Process Research & Development | 2012

A Robust Process for an mGluR5 Negative Allosteric Modulator: Difluoromethylation and Sonogashira Coupling on Large Scale

Jeffrey B. Sperry; Roger Farr; Mahmut Levent; Mousumi Ghosh; Steven M. Hoagland; Richard J. Varsolona; Karen Sutherland

Organic Process Research & Development | 2016

Palbociclib Commercial Manufacturing Process Development. Part I: Control of Regioselectivity in a Grignard-Mediated SNAr Coupling

Shengquan Duan; David William Place; Hahdi H. Perfect; Nathan D. Ide; Mark T. Maloney; Karen Sutherland; Kristin E. Price Wiglesworth; Ke Wang; Mark Olivier; Fangming Kong; Kyle R. Leeman; Jon Blunt; John Draper; Marie McAuliffe; Maria M. O’Sullivan; Denis Lynch

Archive | 2009

Improved process for preparation of coupled products from 4-amino-3-cyanoquinolines using stabilized intermediates

Alexander Gontcharov; Kan Kaung Eng; Karen Sutherland; Alice Sebastian; Qing Yu; David William Place

Organic Process Research & Development | 2016

Palbociclib Commercial Manufacturing Process Development. Part II: Regioselective Heck Coupling with Polymorph Control for Processability

Mark T. Maloney; Brian P. Jones; Mark Olivier; Javier Magano; Ke Wang; Nathan D. Ide; Andrew S. Palm; David R. Bill; Kyle R. Leeman; Karen Sutherland; John Draper; Adrian M. Daly; Joseph Keane; Denis Lynch; Marie O’Brien; Joanne Tuohy

Organic Process Research & Development | 2016

Palbociclib Commercial Manufacturing Process Development. Part III. Deprotection Followed by Crystallization for API Particle Property Control

Brian P. Chekal; Jason Ewers; Steven M. Guinness; Nathan D. Ide; Kyle R. Leeman; Ronald J. Post; Anil M. Rane; Karen Sutherland; Ke Wang; Mark Webster; Gregory J. Withbroe; John Draper; Denis Lynch; Marie McAuliffe; Joseph Keane

Archive | 2007

Synthesis of pyrrolidine compounds

Asaf Alimardanov; Lalitha Krishnan; Maotang Zhou; Ting-Zhong Wang; Jianxin Ren; John Leo Considine; Charles Wu; Jason Brazzillo; Panolil Raveendranath; Karen Sutherland; Mahmoud Mirmehrabi; Subodh Deshmukh

Organic Process Research & Development | 2015

Confirmation of Bosutinib Structure; Demonstration of Controls To Ensure Product Quality

Paul Bowles; Frank Robert Busch; Kyle R. Leeman; Andrew S. Palm; Karen Sutherland

Archive | 2004

Process for the synthesis of 3-(3-fluoro-4-hydroxyphenyl)-7-hydroxynaphthonitrile

Yanzhong Wu; Jianxin Ren; Mousumi Ghosh; Mahmut Levent; Karen Sutherland; Panolil Raveendranath

Organic Process Research & Development | 2015

Development of the Commercial Route for the Manufacture of a 5-Lipoxygenase Inhibitor PF-04191834

Brian P. Chekal; David B. Damon; Danny Lafrance; Kyle R. Leeman; Carlos Mojica; Andrew S. Palm; Michael St. Pierre; Janice E. Sieser; Karen Sutherland; Rajappa Vaidyanathan; John Van Alsten; Brian C. Vanderplas; Carrie Wager; Gerald A. Weisenburger; Gregory J. Withbroe; Shu Yu

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