Katerina Blazek
Stanford University
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Featured researches published by Katerina Blazek.
Journal of Orthopaedic Research | 2014
Katerina Blazek; Julien Favre; J.L. Asay; Jennifer C. Erhart-Hledik; Thomas P. Andriacchi
Articular cartilage is sensitive to mechanical loading, so increased risk of osteoarthritis in older or obese individuals may be linked to changes in the relationship between cartilage properties and extrinsic joint loads. A positive relationship has been reported between ambulatory loads and cartilage thickness in young individuals, but whether this relationship exists in individuals who are older or obese is unknown. This study examined the relationship between femoral cartilage thickness and load, measured by weight × height and the peak adduction moment, in young normal‐weight (28 subjects, age: 28.0 ± 3.8 years, BMI: 21.9 ± 1.9 kg/m2), middle‐aged normal‐weight (27 subjects, 47.0 ± 6.5 years, 22.7 ± 1.7 kg/m2), young overweight/obese (27 subjects, 28.4 ± 3.6 years, 33.3 ± 4.6 kg/m2), and middle‐aged overweight/obese (27 subjects, 45.8 ± 7.2 years, 31.9 ± 4.4 kg/m2) individuals. On the lateral condyle, cartilage thickness was positively correlated with weight × height for all groups (R2 = 0.26–0.20) except the middle‐aged overweight/obese. On the medial condyle, weight × height was significantly correlated only in young normal‐weight subjects (R2 = 0.19), as was the case for the correlation between adduction moment and medial–lateral thickness ratio (R2 = 0.20). These results suggest that aging and obesity are both associated with a loss of the positive relationship between cartilage thickness and ambulatory loads, and that the relationship is dependent on the compartment and whether the load is generated by body size or subject‐specific gait mechanics.
American Journal of Sports Medicine | 2009
Sean F. Scanlan; Katerina Blazek; Ajit M.W. Chaudhari; Marc R. Safran; Thomas P. Andriacchi
Background Anterior cruciate ligament graft orientation has been proposed as a potential mechanism for failure of single-bundle anterior cruciate ligament reconstruction and has been considered important in the restoration of normal ambulatory knee mechanics. Purpose To evaluate the possibility that patients adapt their mechanics of walking to the orientation of the anterior cruciate ligament graft. This was determined by testing the hypothesis that peak external knee flexion moment (net quadriceps moment) during walking in patients with anterior cruciate ligament reconstruction is correlated with coronal and sagittal anterior cruciate ligament graft orientations. Study Design Cross-sectional study; Level of evidence, 3. Methods Gait analysis was performed to assess dynamic knee function during walking in 17 subjects with unilateral anterior cruciate ligament reconstructions. Magnetic resonance imaging was used to measure coronal and sagittal anterior cruciate ligament graft orientations. Results A negative correlation was observed between peak external knee flexion moment during walking and coronal angle of the anterior cruciate ligament graft (1.0 m/s walking speed, r = −0.87, P < .001; 1.3 m/s, r = −0.66, P = .004; 1.6 m/s, r = −0.24, P > .05); no correlation was found with the sagittal graft angle (1.0 m/s walking speed, r = 0.21, P > .05; 1.3 m/s, r = 0.20, P > .05; 1.6 m/s, r = 0.13, P > .05). Conclusion The negative correlation between peak external knee flexion moment during walking and the coronal angle of the anterior cruciate ligament graft indicates that as the anterior cruciate ligament graft is placed in a more vertical coronal orientation, patients reduce their net quadriceps usage during walking. Clinical Relevance This finding supports the hypothesis that graft placement plays a critical role in the restoration of normal ambulatory mechanics after anterior cruciate ligament reconstruction and thus could provide a partial explanation for the increased incidence of premature osteoarthritis at long-term follow-up in patients with anterior cruciate ligament reconstruction.
Journal of Biomechanical Engineering-transactions of The Asme | 2013
Julien Favre; Sean F. Scanlan; Jenifer C. Erhart-Hledik; Katerina Blazek; Thomas P. Andriacchi
Measures of mean cartilage thickness over predefined regions in the femoral plate using magnetic resonance imaging have provided important insights into the characteristics of knee osteoarthritis (OA), however, this quantification method suffers from the limited ability to detect OA-related differences between knees and loses potentially important information regarding spatial variations in cartilage thickness. The objectives of this study were to develop a new method for analyzing patterns of femoral cartilage thickness and to test the following hypotheses: (1) asymptomatic knees have similar thickness patterns, (2) thickness patterns differ with knee OA, and (3) thickness patterns are more sensitive than mean thicknesses to differences between OA conditions. Bi-orthogonal thickness patterns were extracted from thickness maps of segmented magnetic resonance images in the medial, lateral, and trochlea compartments. Fifty asymptomatic knees were used to develop the method and establish reference asymptomatic patterns. Another subgroup of 20 asymptomatic knees and three subgroups of 20 OA knees each with a Kellgren/Lawrence grade (KLG) of 1, 2, and 3, respectively, were selected for hypotheses testing. The thickness patterns were similar between asymptomatic knees (coefficient of multiple determination between 0.8 and 0.9). The thickness pattern alterations, i.e., the differences between the thickness patterns of an individual knee and reference asymptomatic thickness patterns, increased with increasing OA severity (Kendall correlation between 0.23 and 0.47) and KLG 2 and 3 knees had significantly larger thickness pattern alterations than asymptomatic knees in the three compartments. On average, the number of significant differences detected between the four subgroups was 4.5 times greater with thickness pattern alterations than mean thicknesses. The increase was particularly marked in the medial compartment, where the number of significant differences between subgroups was 10 times greater with thickness pattern alterations than mean thickness measurements. Asymptomatic knees had characteristic regional thickness patterns and these patterns were different in medial OA knees. Assessing the thickness patterns, which account for the spatial variations in cartilage thickness and capture both cartilage thinning and swelling, could enhance the capacity to detect OA-related differences between knees.
Journal of Orthopaedic Research | 2013
Katerina Blazek; J.L. Asay; Jennifer C. Erhart-Hledik; Thomas P. Andriacchi
There is a need to understand how obesity and aging interact to cause an increased risk of medial knee osteoarthritis (OA). This study tested whether the knee adduction and flexion moments increase with age in healthy normal‐weight and obese adults, as well as the mechanism of this increase. We analyzed whether ground reaction force magnitude, knee alignment, step width, toe‐out angle, body volume distribution, and limb position (knee position relative to the pelvis center) are associated with the adduction moment and whether these variables also change with age. Ninety‐six healthy volunteers (60 normal‐weight and 36 obese) were tested using marker‐based gait analysis; knee alignment was based on marker positions during quiet standing. Adduction moment increased with age in obese (R2 = 0.19), but not in normal‐weight individuals (R2 = 0.01); knee flexion moment did not change with age in either group. In the obese, only knee alignment and limb position were related to the adduction moment (R2 = 0.19 and 0.51), but only limb position changed with age (R2 = 0.26). The resulting increase in adduction moment suggests greater medial compartment loads, which may combine with elevated levels of inflammation to contribute to the increased risk of medial OA in this population.
Clinical Biomechanics | 2010
Jason L. Dragoo; Carol Phillips; Joshua D. Schmidt; Sean F. Scanlan; Katerina Blazek; J. Richard Steadman; Andy Williams
BACKGROUND The anterior interval of the knee has been defined as the space between the infrapatellar fat pad and patellar tendon anteriorly, and the anterior border of the tibia and the transverse meniscal ligament posteriorly. Investigation of the normal kinematics of this region is necessary as we begin to appreciate the significant impact that pathologic processes of the anterior interval have on the knee. METHODS Non-weight bearing and weight bearing dynamic MRIs of 20 healthy knees were evaluated at 30 degrees intervals from 0 degrees to 120 degrees flexion. The angle subtended by the patellar tendon and the anterior tibia was measured at each interval of flexion by three independent observers. The amount of angular change over each interval of flexion was also evaluated and the differences between the relative weight bearing conditions were statistically evaluated. FINDINGS The angle formed by the anterior tibia and the patellar tendon decreases with knee flexion (45.2 degrees (SD 10.1 degrees ) at full extension vs. 1.2 degrees (SD 2.1 degrees ) at full flexion). The average patellar tendon-tibial angle excursion was significantly reduced with full-weight bearing, 43.1 degrees (SD 11.2 degrees ) from 0 degrees to 120 degrees of flexion, compared to non-weight bearing, 30.9 degrees (SD 6.1 degrees ) over the same range of motion (P<0.001). Full-weight bearing decreased the angle excursion by 28% compared to non-weight bearing. INTERPRETATION The observed changes in the anterior interval are influenced by multiple factors including load, knee architecture, tendon elasticity and tibio-femoral and patello-femoral kinematics. The impact of load on the mechanics of the anterior interval is most pronounced between 0 degrees and 30 degrees of flexion.
Journal of Orthopaedic Research | 2017
Julien Favre; Jennifer C. Erhart-Hledik; Katerina Blazek; Benedikt Fasel; Garry E. Gold; Thomas P. Andriacchi
While cartilage thickness alterations are a central element of knee osteoarthritis (OA), differences among disease stages are still incompletely understood. This study aimed to quantify the spatial‐variations in cartilage thickness using anatomically standardized thickness maps and test if there are characteristic patterns in patients with different stages of medial compartment knee OA. Magnetic resonance images were acquired for 75 non‐OA and 100 OA knees of varying severities (Kellgren and Lawrence (KL) scores 1–4). Three‐dimensional cartilage models were reconstructed and a shape matching technique was applied to convert the models into two‐dimensional anatomically standardized thickness maps. Difference thickness maps and statistical parametric mapping were used to compare the four OA and the non‐OA subgroups. This analysis showed distinct thickness patterns for each clinical stage that formed a coherent succession from the non‐OA to the KL 4 subgroups. Interestingly, the only significant difference for early stage (KL 1) was thicker femoral cartilage. With increase in disease severity, typical patterns developed, including thinner cartilage in the anterior area of the medial condyle (significant for KL 3 and 4) and thicker cartilage in the posterior area of the medial and lateral condyles (significant for all OA subgroups). The tibial patterns mainly consisted of thinner cartilage for both medial and lateral compartments (significant for KL 2–4). Comparing anatomically standardized maps allowed identifying patterns of thickening and thinning over the entire cartilage surface, consequently improving the characterization of thickness differences associated with OA. The results also highlighted the value of anatomically standardized maps to analyze spatial variations in cartilage thickness.
ASME 2012 Summer Bioengineering Conference, Parts A and B | 2012
Katerina Blazek; J.L. Asay; Jennifer C. Erhart-Hledik; Thomas P. Andriacchi
Obesity is a strong risk factor for knee osteoarthritis (OA) [1], but the mechanism of OA initiation associated with obesity is not clear. Increases in ambulatory knee joint load due to obesity have been implicated as a cause of increased OA incidence, since an increased adduction moment has been associated with the severity and progression of medial compartment OA [2]. However, previous work has not consistently shown increases or decreases in the adduction moment in the obese. Step width and toe-out reduce the adduction moment [3] and are increased in the obese [4], suggesting that the adduction moment could also be reduced in the obese. Furthermore, obesity may be associated with knee malalignment, which may also alter the adduction moment. However, the cumulative effect of these gait alterations on the adduction moment is unclear, given the increased risk of medial knee OA in the obese. Understanding this interaction is important in understanding the link between obesity and knee OA.Copyright
ASME 2010 Summer Bioengineering Conference, Parts A and B | 2010
Katerina Blazek; Jennifer C. Erhart; J.L. Asay; Thomas P. Andriacchi
In longitudinal studies, obesity has been shown to be a major risk factor for knee osteoarthritis (OA) (Felson, 1988), but the cause of this increased prevalence is not yet clear. A common hypothesis is that obesity increases joint loads due to increased body mass, causing the articular cartilage to experience higher load and degenerate more quickly (Griffin, 2005). However, it has been shown that in healthy, normal-weight subjects, knee cartilage thickness increases in proportion to the loads applied during ambulation (Andriacchi, 2004). It is not known whether this same relationship also holds true for obese people who do not have OA. Because it is difficult to measure joint loads directly in vivo, the external adduction moment can be used as a surrogate measure of the relative load distribution between the medial and lateral compartments of the knee (Andriacchi 2004). If cartilage responds positively to load, a higher adduction moment will be correlated with thicker cartilage on the medial side and thinner cartilage in the lateral compartment. Similarly, average cartilage thickness should be proportional to body mass index. Therefore the purpose of this study was to examine the following hypotheses in a group of healthy-weight, overweight, and obese individuals: 1. Average cartilage thickness in both compartments is proportional to body mass index (BMI). 2. Average cartilage thickness in the lateral compartment is inversely proportional to the knee adduction moment. 3. Average cartilage thickness in the medial compartment is proportional to the knee adduction moment. 4. The ratio of medial to lateral cartilage thickness is proportional to the adduction moment.Copyright
Gait & Posture | 2014
Rebecca L. Lathrop-Lambach; J.L. Asay; Steve T. Jamison; Xueliang Pan; Laura C. Schmitt; Katerina Blazek; Robert A. Siston; Thomas P. Andriacchi; Ajit M.W. Chaudhari
Osteoarthritis and Cartilage | 2017
Shannon N. Edd; Julien Favre; Katerina Blazek; P. Omoumi; J.L. Asay; Thomas P. Andriacchi