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Kathryn Jane Smith

Research Triangle Park

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Publication

Featured researches published by Kathryn Jane Smith.

Bioorganic & Medicinal Chemistry Letters | 2003

Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines.

Micheal D. Gaul; Yu Guo; Karen Affleck; G. Stuart Cockerill; Tona M. Gilmer; Robert J. Griffin; Stephen Barry Guntrip; Barry R. Keith; Wilson B. Knight; Robert J. Mullin; Doris M. Murray; David W. Rusnak; Kathryn Jane Smith; Sarva M. Tadepalli; Edgar R. Wood; Karen Lackey

We have identified a novel class of 6-thiazolylquinazolines as potent and selective inhibitors of both ErbB-2 and EGFR tyrosine kinase activity, with IC(50) values in the nanomolar range. These compounds inhibited the growth of both EGFR (HN5) and ErbB-2 (BT474) over-expressing human tumor cell lines in vitro. Using xenograft models of the same cell lines, we found that the compounds given orally inhibited in vivo tumor growth significantly compared with control animals.

Cancer Research | 2001

The Characterization of Novel, Dual ErbB-2/EGFR, Tyrosine Kinase Inhibitors: Potential Therapy for Cancer

David W. Rusnak; Karen Affleck; Stuart Cockerill; Colin Stubberfield; Robert J. Harris; Martin John Page; Kathryn Jane Smith; Stephen Barry Guntrip; Malcolm Clive Carter; Robert Shaw; Amanda Jowett; Jeremy N. Stables; Peter Topley; Edgar R. Wood; Perry S. Brignola; Sue H. Kadwell; Bryan R. Reep; Robert J. Mullin; Krystal J. Alligood; Barry R. Keith; Renae M. Crosby; Doris M. Murray; W. Blaine Knight; Tona M. Gilmer; Karen Elizabeth Lackey

Bioorganic & Medicinal Chemistry Letters | 2004

Synthesis and SAR of potent EGFR/erbB2 dual inhibitors

Yue-Mei Zhang; Stuart Cockerill; Stephen Barry Guntrip; David W. Rusnak; Kathryn Jane Smith; Dana E. Vanderwall; Edgar R. Wood; Karen Lackey

Archive | 2003

Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors

Richard Martyn Angell; Paul Bamborough; Ian Robert Baldwin; Anne-Marie Li-Kwai-Cheung; Timothy Longstaff; Suzanne Joy Merrick; Kathryn Jane Smith; Stephen Swanson; Ann Louise Walker

Archive | 2002

Oxadiazolyl-biphenylcarboxamides and their use as p38 kinase inhibitors

Richard Martyn Angell; Paul Bamborough; George Stuart Cockerill; Kathryn Jane Smith; Ann Louise Walker

Archive | 1999

Heteroaromatic protein tyrosine kinase inhibitors

Malcolm Clive Carter; George Stuart Cockerill; Stephen Barry Guntrip; Karen Elizabeth Lackey; Kathryn Jane Smith

Archive | 2002

2' -methyl-5-(1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors

Richard Martyn Angell; Paul Bamborough; George Stuart Cockerill; Kathryn Jane Smith; Ann Louise Walker

Archive | 1997

Kondensierte heterozyklische verbindungen als protein kinase inhibitoren

George Stuart Cockerill; Malcolm Clive Carter; Stephen Barry Guntrip; Kathryn Jane Smith

Archive | 2003

Heteroarylsubstituierte biphenylderivate als inhibitoren von p38-kinase Heteroaryl-substituted biphenyl derivatives as inhibitors of p38 kinase

Richard M. Arrow Therap Angell; Ian R. GlaxoSmithKl Stevenage Baldwin; Paul Stevenage Bamborough; Anne-Marie Li-Kwai-Cheung; Timothy GlaxoSmithKl Stevenage Longstaff; Suzanne Joy c; o Cip Cn . Merrick; Kathryn Jane Smith; Stephen GlaxoSmithKl Stevenage Swanson; Ann Louise Stevenage Walker

Archive | 2003

Heteroaryl-biphenyl derivatives as inhibitors of p38 kinase

Richard Martyn Angell; Paul Bamborough; Ian Robert Baldwin; Anne-Marie Li-Kwai-Cheung; Timothy Longstaff; Suzanne Joy Merrick; Kathryn Jane Smith; Stephen Swanson; Ann Louise Walker

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Collaboration

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Stephen Barry Guntrip

Research Triangle Park

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George Stuart Cockerill

University of California

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Malcolm Clive Carter

University of Hertfordshire

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Karen Elizabeth Lackey

Duke University

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Ann Louise Walker

GlaxoSmithKline

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Paul Bamborough

GlaxoSmithKline

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Richard Martyn Angell

GlaxoSmithKline

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David W. Rusnak

Research Triangle Park

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Edgar R. Wood

Research Triangle Park

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Barry R. Keith

Research Triangle Park

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