Kathy Derakhchan

Detection of QTc interval prolongation using jacket telemetry in conscious non-human primates: comparison with implanted telemetry

During repeat‐dose toxicity studies, ECGs are collected from chemically or physically‐restrained animals over a short timeframe. This is problematic due to cardiovascular changes caused by manual restraint stress and anesthesia, and limited ECG sampling. These factors confound data interpretation, but may be overcome by using a non‐invasive jacket‐based ECG collection (JET). The current study investigated whether a jacketed external telemetry system could detect changes in cardiac intervals and heart rate in non‐human primates (NHPs), previously implanted with a PCT transmitter.