Katrina L. Kelner

Five Years of Advancing Science, Improving Health

On its 5-year anniversary, Science Translational Medicine highlights its published research papers that have spurred encouraging translational progress.

Science Translational Medicine Podcast: 28 March 2012

A conversation with Bert Vogelstein about how far we have come in understanding cancer and what we still need to do to successfully conquer the disease. A conversation with Bert Vogelstein about how far we have come in understanding cancer and what we still need to do to successfully conquer the disease. Length: 9:58 min File size: 9.36 MB File format: Mp3 Listen to Podcast: http://podcasts.aaas.org/science_transl_med/ScienceTranslMed_120328.mp3 Download the Transcript (Adobe PDF format)

Science Translational Medicine Podcast: 5 May 2010

A conversation with Science Translational Medicines Senior Scientific Advisor about the unique challenges and benefits of combining engineering and biology in translational medicine. A conversation with Science Translational Medicines Senior Scientific Advisor about the unique challenges and benefits of combining engineering and biology in translational medicine. Length: 15 min File size: 6.7 MB File Format: mp3 Download Podcast: http://podcasts.aaas.org/science_transl_med/ScienceTranslMed_100505.mp3 Download the Transcript (Adobe PDF format)

A Better Bionic Heart

Patients with a new type of heart pump that has a rotor to drive blood flow instead of a piston survive better because they have fewer complications. Patients with a new type of heart pump that has a rotor to drive blood flow instead of a piston survive better because they have fewer complications.

Heart Valve Job

Bovine pericardium impregnated with cell-attracting proteins becomes engrafted with cells when used as replacement heart valves in sheep, functioning well for at least 5 months. Bovine pericardium impregnated with cell-attracting proteins becomes engrafted with cells when used as replacement heart valves in sheep, functioning well for at least 5 months.

How Some Monkeys Tolerate SIV

Both susceptible and resistant monkey species respond immunologically to SIV infection, but only resistant ones can dampen the response to avoid disease. Both susceptible and resistant monkey species respond immunologically to SIV infection, but only resistant ones can dampen the response to avoid disease.

A Protective Genetic Variant for Lungs

Analysis of seven independent groups of subjects uncovers a metalloproteinase variant that protects against lung damage—but only in smokers and people with lung disease. Analysis of seven independent groups of subjects uncovers a metalloproteinase variant that protects against lung damage—but only in smokers and people with lung disease.

Protection from Hemoglobin's Dark Side

A naturally occurring protein that binds hemoglobin protects the brain from damage after a bleeding stroke, offering a potential therapeutic approach. A naturally occurring protein that binds hemoglobin protects the brain from damage after a bleeding stroke, offering a potential therapeutic approach.