Katsuhisa Shindo

Significance of Schistosomiasis japonica in the development of cancer of the large intestine: report of a case and review of the literature.

SummaryA 68-year-old man had a tumor in the ascending colon, following schistosomiasis 58 years earlier. Right hemicolectomy was performed. Examination of the specimen showed adenocarcinoma with schistosomiasis japonica. A total of 276 such cases in medical literature were reviewed. There were promoting factor rather than a direct carcinogenic factor in the development of adenocarcinoma of the large intestine.

Effects of chronic renal failure on wound healing in rats. II. Microscopic study and hydroxyproline assay.

Incisional wounds of the abdominal skin, aponeurosis, stomach and colon were investigated microscopically for a comparison of the findings between uremic and normal rats. The grade of edema and number of inflammatory cells were increased in the rats with uremia and the granulation zone was also larger in the uremics. Hydroxyproline was assayed in the wound tissues by a modification of the technique of Stegemann and Stalder.2 The hydroxyproline level was lower in the uremics (p<0.05) only in the aponeurosis of the 5th postoperative day and in the colon of the 3.5th to 7th day. The correlation coefficient calculated for the blood urea level, biomechanical strength and hydroxyproline level was nil. If these results can validly be extrapolated to patients with chronic renal failure, careful management and avoidance of possible wound infections is of the greatest importance for surgical patients.

Effects of chronic renal failure on wound healing in rats

Chronic renal failure was induced in rats by a five-sixths nephrectomy, after which incisional wounds were made in the abdominal skin, aponeurosis of linea alba, stomach and colon. Bursting strength of the colon and tensile strength of the skin, aponeurosis and stomach were usually lower in the uremics than in the controls, but there was no statistical significance except for colonic wounds on the 7th and 10th postoperative days. Before these results can be extrapolated to clinical cases, pre- and post-surgical treatment must be considered, because immunosuppressants, anticoagulants, and other compounds may influence the retardation of wound healing.