Kayo Harada

In-vitro Permeability to Salicylic Acid of Human, Rodent, and Shed Snake Skin

Abstract— In‐vitro permeability to salicylic acid of human, rodent, and shed snake skin has been examined for the purpose of selecting model membranes for human skin corresponding to different anatomic sites, since a marked regional variation is suggested among the different sites. The greatest permeability to salicylic acid was observed in the scrotum, that of the sole was negligible. The cheek, neck, and inguinal skin seemed more permeable than the breast, back, thigh, lower leg, or foot skin. Shed snake and skin of hairless rat were found to show similar permeability to human breast and thigh skin. Wistar rat and nude mouse skin showed similar permeability to human cheek, neck, and inguinal skin.

Generalised granuloma annulare associated with myelodysplastic syndrome

Granuloma annulare (GA) is a benign inflammatory dermatosis. Several systemic diseases can be associated with generalised GA, including diabetes mellitus, thyroid disease, hepatitis B and C, Borrelia infection, and neoplastic diseases. We report a patient with generalised GA which was the initial manifestation of myelodysplastic syndrome (MDS).A 62-year-old woman presented with an eight-month history of disseminated red papules with mild pruritus on the trunk and extremities (figure 1A). The papules [...]