Kázmér Karádi

Sex role identity related to the ratio of second to fourth digit length in women

Prenatal gonadal hormones have been implicated as important factors in the development of sex-role identity. The aim of the study reported here was to examine the relationship between adult sex-role preference and the second to fourth digit ratio (2D:4D ratio) in healthy women. There is evidence that the ratio of the length of second and fourth digits associates negatively with prenatal testosterone and positively with prenatal oestrogen. In this study the 2D:4D ratio was measured on a sample of 46 female university students. The subjects completed the form of the Bem Sex Role Inventory (BSRI). It was found that the lower 2D:4D ratios associated significantly with higher, masculinized bias scores in BSRI indicating that 2D:4D ratio predicts the female or male self-reported sex-role identity in females.

Cognitive and affective aspects of thigmotaxis strategy in humans.

The present article describes the cognitive and emotional aspects of human thigmotaxis (a wall-following spatial strategy) during exploration of virtual and physical spaces. The authors assessed 106 participants with spatial and nonspatial performance-based learning-memory tasks and with fear and anxiety questionnaires. The results demonstrate that thigmotaxis plays a distinct role at different phases of spatial learning. The 1st phase shows a positive correlation between thigmotaxis and general phobic avoidance, whereas there is no association between thigmotaxis and general phobic avoidance during later phases of learning. Furthermore, participants who underperformed in working memory tests and in a spatial construction task exhibited greater thigmotaxis and a higher potential for fear response. Findings are interpreted in the framework of interactions among emotion-, action-, and knowledge-controlled spatial learning theories.

Sensitivity and specificity of Addenbrooke's Cognitive Examination, Mattis Dementia Rating Scale, Frontal Assessment Battery and Mini Mental State Examination for diagnosing dementia in Parkinson's disease

INTRODUCTION Among the non-motor features of Parkinsons disease (PD), cognitive impairment is one of the most troublesome problems. Highly sensitive and specific screening instruments for detecting dementia in PD (PDD) are required in the clinical practice. METHODS In our study we evaluated the sensitivity and specificity of different neuropsychological tests (Addenbrookes Cognitive Examination, ACE; Frontal Assessment Battery, FAB and Mattis Dementia Rating Scale, MDRS) in 73 Parkinsons disease patients without depression. By receiver operating characteristic curve analysis, these screening instruments were tested against the recently established clinical diagnostic criteria of PDD. RESULTS Best cut-off score for ACE to identify PDD was 80 points (sensitivity = 74.0%, specificity = 78.1%). For FAB the most optimal cut-off value was 12 points (sensitivity = 66.3%, specificity = 72.2%); whereas for MDRS it was 125 points (sensitivity = 89.8%, specificity = 98.3%). Among the examined test batteries, MDRS had the best clinicometric profile for detecting PDD. CONCLUSION Although the types of applied screening instruments might differ from movement disorder clinic to clinic within a country, determination of the most specific and sensitive test for the given population remains to be an important task. Our results demonstrated that the specificity and sensitivity of MDRS was better than those of ACE, FAB and MMSE in Hungary. However, further studies with larger sample size and more uniform criteria for participation are required to determine the most suitable screening instrument for cognitive impairment.

Spatial orientation strategies in morris-type virtual water task for humans

The present study characterized frequent motion patterns (search strategies) that occurred during spatial navigation in a virtual maze. The research focused on identifying and characterizing some search strategies, the temporal progression of strategy-use, and their role in spatial performance. Participants were 112 undergraduate students (42 males and 70 females). We identified three search strategies that predicted spatial performance. Enfilading refers to an approach-withdrawal pattern of active exploration near a target location. Thigmotaxis refers to a search strategy that involves continuous contact with the circular wall of the maze. Visual scan involves active visual exploration while the subject remains in a fixed spatial location and turns round. In addition to identifying these motion patterns, some significant points of the spatial learning process were also detailed where strategies appeared to shift systematically. The applied search strategies in these transitional points have determined overall spatial performance.

Effects of androgenization on the white matter microstructure of female-to-male transsexuals. A diffusion tensor imaging study

Diffusion tensor imaging (DTI) can sensitively detect white matter sex differences and the effects of pharmacological treatments. Before cross-sex hormone treatment, the white matter microstructure of several brain bundles in female-to-male transsexuals (FtMs) differs from those in females but not from that in males. The purpose of this study was to investigate whether cross-sex hormone treatment (androgenization) affects the brain white matter microstructure. Using a Siemens 3 T Trio Tim Magneton, DTI was performed twice, before and during cross-sex hormonal treatment with testosterone in 15 FtMs scanned. Fractional anisotropy (FA) was analyzed on white matter of the whole brain, and the latter was spatially analyzed using Tract-Based Spatial Statistics. Before each scan the subjects were assessed for serum testosterone, sex hormone binding globulin level (SHBG), and their free testosterone index. After at least seven months of cross-gender hormonal treatment, FA values increased in the right superior longitudinal fasciculus (SLF) and the right corticospinal tract (CST) in FtMs compared to their pre-treatment values. Hierarchical regression analyses showed that the increments in the FA values in the SLF and CST are predicted by the free testosterone index before hormonal treatment. All these observations suggest that testosterone treatment changes white matter microstructure in FtMs.

Cortical activation during mental rotation in male-to-female and female-to-male transsexuals under hormonal treatment

There is strong evidence of sex differences in mental rotation tasks. Transsexualism is an extreme gender identity disorder in which individuals seek cross-gender treatment to change their sex. The aim of our study was to investigate if male-to-female (MF) and female-to-male (FM) transsexuals receiving cross-sex hormonal treatment have different patterns of cortical activation during a three-dimensional (3D) mental rotation task. An fMRI study was performed using a 3-T scan in a sample of 18 MF and 19 FM under chronic cross-sex hormonal treatment. Twenty-three males and 19 females served as controls. The general pattern of cerebral activation seen while visualizing the rotated and non-rotated figures was similar for all four groups showing strong occipito-parieto-frontal brain activation. However, compared to control males, the activation of MF transsexuals during the task was lower in the superior parietal lobe. Compared to control females, MF transsexuals showed higher activation in orbital and right dorsolateral prefrontal regions and lower activation in the left prefrontal gyrus. FM transsexuals did not differ from either the MF transsexual or control groups. Regression analyses between cerebral activation and the number of months of hormonal treatment showed a significant negative correlation in parietal, occipital and temporal regions in the MF transsexuals. No significant correlations with time were seen in the FM transsexuals. In conclusion, although we did not find a specific pattern of cerebral activation in the FM transsexuals, we have identified a specific pattern of cerebral activation during a mental 3D rotation task in MF transsexuals under cross-sex hormonal treatment that differed from control males in the parietal region and from control females in the orbital prefrontal region. The hypoactivation in MF transsexuals in the parietal region could be due to the hormonal treatment or could reflect a priori cerebral differences between MF transsexual and control subjects.

Screening Mild and Major Neurocognitive Disorders in Parkinson’s Disease

Introduction. Among the nonmotor features of Parkinsons disease (PD), cognitive impairment is one of the most troublesome problems. New diagnostic criteria for mild and major neurocognitive disorder (NCD) in PD were established by Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5). The aim of our study was to establish the diagnostic accuracy of widely used screening tests for NCD in PD. Methods. Within the scope of our study we evaluated the sensitivity and specificity of different neuropsychological tests (Addenbrookes Cognitive Examination (ACE), Mattis Dementia Rating Scale (MDRS), Mini Mental State Examination (MMSE), and Montreal Cognitive Assessment (MoCA)) in 370 PD patients without depression. Results. MoCA and ACE feature the finest diagnostic accuracy for detecting mild cognitive disorder in PD (DSM-5) at the cut-off scores of 23.5 and 83.5 points, respectively. The diagnostic accuracy of these tests was 0.859 (95% CI: 0.818–0.894, MoCA) and 0.820 (95% CI: 0.774–0.859, ACE). In the detection of major NCD (DSM-5), MoCA and MDRS tests exhibited the best diagnostic accuracy at the cut-off scores of 20.5 and 132.5 points, respectively. The diagnostic accuracy of these tests was 0.863 (95% CI: 0.823–0.897, MoCA) and 0.830 (95% CI: 0.785–0.869, MDRS). Conclusion. Our study demonstrated that the MoCA may be the most suitable test for detecting mild and major NCD in PD.

Cognitive subprocesses of mental rotation: why is a good rotator better than a poor one?

The Vanderberg-Kuse Mental Rotation Test is a standard test of mental rotation ability. Recent experiments have demonstrated that mental rotation is a complex cognitive process wherein different subprocesses (focused attention, visual scanning, perceptual decision, visual memory) play important roles in performance. We classified the population as good and poor rotators by performance of mental rotation (n s = 47: 22 men and 25 women, respectively; mean age: 20.7 yr.). To examine differences cognitive subprocesses of mental rotation of these two groups were compared. There were significant differences between poor and good rotators in performance on Ravens test and the Pieron Focused Attention test scores. The good rotators scored better because their perceptual decision-analytical intelligence (Raven) and focused attention scores were higher.

SEX DIFFERENCES ON THE HAND MENTAL ROTATION TASK FOR 9-YR.-OLD CHILDREN AND YOUNG ADULTS

The Hand Mental Rotation task is assumed to activate an egocentric spatial reference frame to realize mental rotation. This study presents significant sex differences in hand mental rotation performances between men and women (n = 23 and 25, respectively; age: 20.7 yr.). Differences in hand mental rotation in school girls and boys (ns = 48 and 41, respectively; age: 9 yr) were not significant. Our results suggest that the change in sex differences in egocentric mental rotation may occur with developmental change. This requires further testing with a larger sample so testing can occur at several ages between 9 and 20.7 years.

Neurokognitív zavarok diagnosztizálási és kezelési lehetőségei Parkinson-kórban

Absztrakt Az osszefoglalo kozlemenyben a szerzők reszletesen bemutatjak a Parkinson-korhoz tarsulo neurokognitiv zavarok jellegzetessegeit, felmeresuk lehetseges modjait es kezelesi lehetősegeit. A neurokognitiv zavarok meghatarozasat sokaig nehezitette a diagnosztikai kriteriumrendszerek sokszinűsege. Az Amerikai Pszichiatriai Tarsasag altal a Mentalis Rendellenessegek Kormeghatarozo es Statisztikai Kezikonyvenek otodik atdolgozasa (Diagnostic and Statistical Manual of Mental Disorders, DSM-5) magaval hozta a major es az enyhe neurokognitiv zavar megnevezeseket a demencia es az enyhe kognitiv zavar fogalmat helyettesitendően. A DSM-5 neurokognitiv zavarra vonatkozo definicioi a klinikumban jol alkalmazhatoak, am szuksegesse valt a leggyakrabban hasznalt szűrőtesztek, ugymint a Mini-Mental Status Vizsgalat, az Addenbrooke Kognitiv Vizsgalat, a Montreal Kognitiv Felmeres es a Mattis Demencia Pontozo Skala uj kriteriumrendszerhez valo adaptalasa. Magyar Parkinson-koros populacion vegzett validalasi vizsgala...