Kazuhito Miyachi
Dokkyo University
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Featured researches published by Kazuhito Miyachi.
Gastric Cancer | 2003
Kazuhito Miyachi; Kinro Sasaki; Shinichi Onodera; Taizo Taguchi; Masao Nagamachi; Hiromi Kaneko; Masakatsu Sunagawa
BackgroundCorrelations between the malignant potential and prognosis of cancer and abnormal control mechanisms of apoptosis have been discovered in a variety of cancers. Survivin is a member of the inhibiting apoptosis protein family that is abundant in embryonic and carcinoma tissues. We measured the expression of survivin mRNA in gastric cancer to determine whether levels of survivin mRNA expression could serve as an index of malignancy.MethodsExpression of survivin mRNA was measured in samples of both gastric cancer and noncancerous tissue from 107 patients. Survivin mRNA was detected by the real-time polymerase chain reaction (PCR) method, and then the relationship between the survivin mRNA level and histological diagnosis was analyzed.ResultsExpression of survivin mRNA was observed in 105 of 107 cancerous tissues and in 101 of 107 noncancerous tissues. The Mean value of survivin mRNA expression in cancerous tissue was 5.18 ± 1.30, significantly higher (P ≪ 0.01) than that in noncancerous tissue, at 4.21 ± 1.48. No significant differences were found in the values of survivin mRNA expression according to histological classification or according to increasing depth of tumor invasion. However, survivin mRNA expression was significantly higher (P ≪ 0.01) in patients displaying lymph node metastasis (5.48 ± 1.01) than in patients without the metastasis (4.70 ± 1.55).ConclusionsThese results indicate that increased survivin mRNA expression begins in the early stages of gastric carcinogenesis. Moreover, the level of survivin mRNA expression may indicate the potential for lymph node metastasis in patients with gastric cancer.
World Journal of Gastroenterology | 2010
Kohei Tsuchida; Michiko Yamagata; Yasuyuki Saifuku; Dan Ichikawa; Kazunari Kanke; Toshimitsu Murohisa; Masaya Tamano; Makoto Iijima; Yukiko Nemoto; Wataru Shimoda; Toshiaki Komori; Hirokazu Fukui; Kazuhito Ichikawa; Hitoshi Sugaya; Kazuhito Miyachi; Takahiro Fujimori; Hideyuki Hiraishi
Nihon Gekakei Rengo Gakkaishi (journal of Japanese College of Surgeons) | 2002
Yukiko Nemoto; Tetsuya Ohkawa; Yoshitomo Soeda; Isamu Itoh; Kazuhito Miyachi; Mitsuo Nanba; Masakatsu Sunagawa
Acta Gastro-Enterologica Belgica | 2002
Kinro Sasaki; Kazuhito Miyachi; Hidekazu Aoki; Shinichi Onodera; Taizou Taguchi; Masao Nagamachi; Norihito Yoda; Hiromi Kaneko; Hideo Kurayama; Munenori Azuma; Etsuo Takada; Masakatsu Sunagawa
Dokkyo journal of medical sciences | 2006
Tetsuya Ohkawa; Kazuhito Miyachi
Nihon Gekakei Rengo Gakkaishi (journal of Japanese College of Surgeons) | 2002
Taizo Taguchi; Kazuhito Miyachi; Hiromi Kaneko; Kinro Sasaki; Mitsuo Nanba; Masakatsu Sunagawa
Nihon Gekakei Rengo Gakkaishi (journal of Japanese College of Surgeons) | 1999
Noriko Yamaguchi; Kazuhito Miyachi; Masakatsu Sunagawa
Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1998
Noriko Yamaguchi; Isamu Ito; Yasuhiro Nozaki; Kazuhito Miyachi; Masakatsu Sunagawa; Nobuhide Masawa
Dokkyo journal of medical sciences | 1993
R. Hashimoto; H. Hamashima; H. Kaneko; N. Doi; Kazuhito Miyachi; M. Azuma; M. Namba; S. Shida; T. Sato; F. Koike; H. Sasaki; N. Masawa; T. Yamada
Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1992
Nobuaki Doi; Kazuhito Miyachi; Yasuhiro Nozaki; Ryuji Hashimoto; Munenori Azuma; Mitsuo Nanba; Syoichi Ikeguchi; Shigemitsu Shida