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Featured researches published by Kazuhito Miyachi.


Gastric Cancer | 2003

Correlation between survivin mRNA expression and lymph node metastasis in gastric cancer

Kazuhito Miyachi; Kinro Sasaki; Shinichi Onodera; Taizo Taguchi; Masao Nagamachi; Hiromi Kaneko; Masakatsu Sunagawa

BackgroundCorrelations between the malignant potential and prognosis of cancer and abnormal control mechanisms of apoptosis have been discovered in a variety of cancers. Survivin is a member of the inhibiting apoptosis protein family that is abundant in embryonic and carcinoma tissues. We measured the expression of survivin mRNA in gastric cancer to determine whether levels of survivin mRNA expression could serve as an index of malignancy.MethodsExpression of survivin mRNA was measured in samples of both gastric cancer and noncancerous tissue from 107 patients. Survivin mRNA was detected by the real-time polymerase chain reaction (PCR) method, and then the relationship between the survivin mRNA level and histological diagnosis was analyzed.ResultsExpression of survivin mRNA was observed in 105 of 107 cancerous tissues and in 101 of 107 noncancerous tissues. The Mean value of survivin mRNA expression in cancerous tissue was 5.18 ± 1.30, significantly higher (P ≪ 0.01) than that in noncancerous tissue, at 4.21 ± 1.48. No significant differences were found in the values of survivin mRNA expression according to histological classification or according to increasing depth of tumor invasion. However, survivin mRNA expression was significantly higher (P ≪ 0.01) in patients displaying lymph node metastasis (5.48 ± 1.01) than in patients without the metastasis (4.70 ± 1.55).ConclusionsThese results indicate that increased survivin mRNA expression begins in the early stages of gastric carcinogenesis. Moreover, the level of survivin mRNA expression may indicate the potential for lymph node metastasis in patients with gastric cancer.


World Journal of Gastroenterology | 2010

Successful endoscopic procedures for intraductal papillary neoplasm of the bile duct: A case report

Kohei Tsuchida; Michiko Yamagata; Yasuyuki Saifuku; Dan Ichikawa; Kazunari Kanke; Toshimitsu Murohisa; Masaya Tamano; Makoto Iijima; Yukiko Nemoto; Wataru Shimoda; Toshiaki Komori; Hirokazu Fukui; Kazuhito Ichikawa; Hitoshi Sugaya; Kazuhito Miyachi; Takahiro Fujimori; Hideyuki Hiraishi


Nihon Gekakei Rengo Gakkaishi (journal of Japanese College of Surgeons) | 2002

Correlation of HER-2 Protein Expression and Clinicopathological Factor in Primary Breast Cancer

Yukiko Nemoto; Tetsuya Ohkawa; Yoshitomo Soeda; Isamu Itoh; Kazuhito Miyachi; Mitsuo Nanba; Masakatsu Sunagawa


Acta Gastro-Enterologica Belgica | 2002

ENDOSCOPIC ULTRASONOGRAPHY OF THE GRANULOMA IN GASTRIC ANISAKIASIS

Kinro Sasaki; Kazuhito Miyachi; Hidekazu Aoki; Shinichi Onodera; Taizou Taguchi; Masao Nagamachi; Norihito Yoda; Hiromi Kaneko; Hideo Kurayama; Munenori Azuma; Etsuo Takada; Masakatsu Sunagawa


Dokkyo journal of medical sciences | 2006

Plasma Endostatin Levels are Elevated in Patients with Gastric Carcinoma

Tetsuya Ohkawa; Kazuhito Miyachi


Nihon Gekakei Rengo Gakkaishi (journal of Japanese College of Surgeons) | 2002

An Immunohistochemical Study of Apoptosis for Chemotherapeutic Effect on Gastric Cancer : Correlation with Mitochondrial Apoptotic Pathway

Taizo Taguchi; Kazuhito Miyachi; Hiromi Kaneko; Kinro Sasaki; Mitsuo Nanba; Masakatsu Sunagawa


Nihon Gekakei Rengo Gakkaishi (journal of Japanese College of Surgeons) | 1999

Telomerase Activity and Proliferative Status in Gastric Cancer

Noriko Yamaguchi; Kazuhito Miyachi; Masakatsu Sunagawa


Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1998

A CASE OF PLEOMORPHIC LIPOSARCOMA OF THE GREATER OMENTUM

Noriko Yamaguchi; Isamu Ito; Yasuhiro Nozaki; Kazuhito Miyachi; Masakatsu Sunagawa; Nobuhide Masawa


Dokkyo journal of medical sciences | 1993

A case of adenocarcinoma arising in Barretts esophagus

R. Hashimoto; H. Hamashima; H. Kaneko; N. Doi; Kazuhito Miyachi; M. Azuma; M. Namba; S. Shida; T. Sato; F. Koike; H. Sasaki; N. Masawa; T. Yamada


Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1992

A CLINICAL STUDY OF PERFORATION OF GASTRODUODENAL ULCER

Nobuaki Doi; Kazuhito Miyachi; Yasuhiro Nozaki; Ryuji Hashimoto; Munenori Azuma; Mitsuo Nanba; Syoichi Ikeguchi; Shigemitsu Shida

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