Kazuki Shimizu
Chugai Pharmaceutical Co.
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Publication
Featured researches published by Kazuki Shimizu.
Bioorganic & Medicinal Chemistry | 2011
Hirotaka Kashiwagi; Yoshiyuki Ono; Kazuki Shimizu; Tsuyoshi Haneishi; Susumu Ito; Shigeyuki Iijima; Takamitsu Kobayashi; Fumihiko Ichikawa; Suguru Harada; Hideki Sato; Nobuo Sekiguchi; Masaki Ishigai; Tadakatsu Takahashi
Novel vitamin D(3) analogs with carboxylic acid were explored, focusing on a nonsecosteroidal analog, LG190178, with a bisphenyl skeleton. From X-ray analysis of these analogs with vitamin D receptor (VDR), the carboxyl groups had very unique hydrogen bonding interactions in VDR and mimicked 1α-hydroxy group and/or 3β-hydroxy group of 1α,25-dihydroxyvitamin D(3). A highly potent analog, 6a, with good in vitro activity and pharmacokinetic profiles was identified from an SAR study. Compound 6a showed significant prevention of bone loss in a rat osteoporosis model by oral administration.
Organic Process Research & Development | 2005
Hitoshi Shimizu; Kazuki Shimizu; Noboru Kubodera; Tetsuhiro Mikami; Kaname Tsuzaki; Hiroyuki Suwa; Koji Harada; Akira Hiraide; Motoki Shimizu; Kaichiro Koyama; Yoshihide Ichikawa; Daisuke Hirasawa; Yasushi Kito; Mio Kobayashi; Masaharu Kigawa; Masahiro Kato; Toshiro Kozono; Hideki Tanaka; Makoto Tanabe; Masanori Iguchi; Mitsutaka Yoshida
Bioorganic & Medicinal Chemistry | 2006
Kazuki Shimizu; Akira Kawase; Tsuyoshi Haneishi; Yasuharu Kato; Takamitsu Kobayashi; Nobuo Sekiguchi; Tessai Yamamoto; Masaki Ishigai; Kazuo Tokuda; Tomochika Matsushita; Shin Shimaoka; Kazumi Morikawa
Bioorganic & Medicinal Chemistry Letters | 2006
Kazuki Shimizu; Akira Kawase; Tsuyoshi Haneishi; Yasuharu Kato; Kazutomo Kinoshita; Masayuki Ohmori; Yoshiyuki Furuta; Takashi Emura; Nobuaki Kato; Tetsuya Mitsui; Koji Yamaguchi; Keiichi Morita; Nobuo Sekiguchi; Tessai Yamamoto; Tomochika Matsushita; Shin Shimaoka; Atsuko Sugita; Kazumi Morikawa
Tetrahedron Letters | 2004
Hitoshi Shimizu; Kazuki Shimizu; Noboru Kubodera; Kenichi Yakushijin; David A. Horne
Archive | 2005
David Wallace; Thomas Arrhenius; Anna Russell; Dingguo Liu; Amy Xing; Sovouthy Tith; Zheng Hou; Tadakatsu Takahashi; Yoshiyuki Ono; Hirotaka Kashiwagi; Kazuki Shimizu; Hitoshi Ikura
Heterocycles | 2004
Hitoshi Shimizu; Kazuki Shimizu; Noboru Kubodera; Kenichi Yakushijin; David Horne
Tetrahedron Letters | 2004
Hitoshi Shimizu; Kazuki Shimizu; Yasushi Uchiyama; Atsuko Sugita; Tetsuhiro Mikami; Tsuyoshi Yamauchi; Masahiro Kato; Kazumi Morikawa
Archive | 2006
Tadakatsu Takahashi; Yoshiyuki Ono; Hirotaka Kashiwagi; Tsuyoshi Haneishi; Kazuki Shimizu
Archive | 2003
Kazumi Morikawa; Ohmori; Kazuki Shimizu
